Correction to: miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a

Cao, Manqing; You, A-Bin; Zhu, Xiao‐Dong; Zhang, Wei; Zhang, Yuanyuan; Zhang, Shi-Zhe; Zhang, Kei-wei; Cai, Hao; Shi, Wen-Kai; Li, Xiaolong; Li, Kangshuai; Gao, Dongmei; Ma, Dongjie; Ye, Bo-Gen; Wang, Cheng-Hao; Qin, Chengdong; Sun, Hui-Chan; Zhang, Ti; Tang, Zhao–You

doi:10.1186/s13045-018-0599-z

Cited by 21 publications

(17 citation statements)

References 1 publication

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“…Previous studies have confirmed that the overexpression of miR‐182 and miR‐93 could significantly promote cell proliferation, migration, and invasion by directly targeting antioncogenes. Moreover, the high expression of miR‐182 and miR‐93 is significantly correlated with poor prognosis in LUAC and many other carcinomas . Subsequent rescue experiments showed that transfecting miR‐182 and miR‐93 mimics into circCRIM1‐overexpressing LUAC cells significantly reduced the circCRIM1‐mediated suppression of cell invasion and migration.…”

Section: Resultsmentioning

confidence: 99%

Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)‐182/miR‐93‐leukemia inhibitory factor receptor pathway

et al. 2019

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In recent years, circular RNAs (circRNAs) have been revealed to have important roles in carcinogenesis. Metastasis is the leading cause of lung adenocarcinoma (LUAC) death. However, the contributions of circRNA to the metastasis of LUAC remain largely unknown. Based on circBase data and our biobank tissues, we identified circCRIM1 (a circRNA derived from exons 2, 3 and 4 of the CRIM1 gene, hsa_circ_0002346) as having a significantly decreased expression in LUAC samples compared with matched normal control samples. Both in vivo and in vitro experiments revealed that circCRIM1 suppresses the invasion and metastasis of LUAC. In vitro precipitation of circRNAs, luciferase reporter assay, and biotin‐coupled microRNA capture were carried out to investigate the Ago2‐dependent interaction of circCRIM1 and microRNA (miR)‐93/miR‐182. Mechanistically, we found that circCRIM1 could promote the expression of leukemia inhibitory factor receptor, a well‐known tumor suppressor, by sponging miR‐93 and miR‐182. In the clinical and pathological analyses, the downregulation of circCRIM1 in LUAC was significantly correlated with lymphatic metastasis and TNM stage, which served as an independent risk factor for the overall survival of patients with LUAC. Our study showed that circCRIM1 inhibits the invasion and metastasis of lung adenocarcinoma cancer cells, which makes it a potential therapeutic target.

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Section: Resultsmentioning

confidence: 99%

Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)‐182/miR‐93‐leukemia inhibitory factor receptor pathway

et al. 2019

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“…As a member of miR-183 family, miR-182-5p plays a key and complex role in diverse kinds of tumors by acting as oncogene and tumor suppressor. For instance, miR-182-5p inhibits renal cell cancer (RCC) cell proliferation, invasion and apoptosis by regulating PI3K/AKT/mTOR pathway [9]; miR-182-5p suppresses non-small cell lung cancer (NSCLC) cell proliferation, invasion and invadopodia formation by targeting cortical, an actin-associated protein [10, 39]; miR-182 reduces proliferation of human osteosarcoma cell (OS) by targeting HOXA9 [12]; miR-182 acts as an oncogene and promote hepatocellular cancer (HCC) progression by targeting FOXO3a [40]; In gastric adenocarcinoma, miR-182 inhibit tumor growth by targeting cAMP responsive element binding protein 1 (CREB1) [41]. Due to the numerous miR-182 target genes, the mechanisms of miR-182 involving in tumorigenesis is quite complex, even be inconsistent.…”

Section: Discussionmentioning

confidence: 99%

miR-182-5p affects human bladder cancer cell proliferation, migration and invasion through regulating Cofilin 1

Wang

Zhou

et al. 2019

Cancer Cell Int

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Background Human bladder cancer is one of the common malignant tumors, and it mainly occurs in men. miR-182-5p, a member of miR-183 family, acts as tumor suppressor or oncogene in various kinds of tumors. In this study, we first investigate that the absence of miR-182-5p in human bladder cancer promotes tumor growth by regulating the expression of Cofilin 1, an actin modulating-protein. Methods Human bladder tumor tissue specimens were collected to detect the expression of miR-182-5p and Cofilin 1 by qRT-PCR. Luciferase activity assay was performed to demonstrate the regulation of Cofilin 1 mRNA 3′UTR by miR-182-5p. Then, cell experiments were performed to analysis the effect of miR-182-5p/Cofilin 1 pathway on tumor cell proliferation, migration, invasion and colony forming efficiency. Finally, xenograft tumor models were established to evaluate the role of miR-182-5p in tumorigenesis abilities in vivo. Results qRT-PCR and Western blotting analysis showed that Cofilin 1 expression was up-regulated in both bladder cancer tissues and cell lines compared with normal. Luciferase activity assay showed that miR-182-5p specifically targets Cofilin 1 mRNA 3′UTR and represses the expression of Cofilin 1. Also, miR-182-5p inhibited bladder tumor cell proliferation, migration, invasion and colony forming efficiency. Furthermore, xenograft tumor model assay showed that miR-182-5p plays a negative role in bladder cancer tumorigenesis abilities in vivo. Conclusion Present results suggest that miR-182-5p could inhibit human bladder tumor growth by repressing Cofilin 1 expression. Our findings may provide a new horizon for exploring therapeutic target of bladder cancer.

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“…Furthermore, it has been suggested that CKLF-like MARVEL transmembrane domain-containing protein 5 may function as a tumor suppressor in human HCC and represent a valuable therapeutic target (11). microRNA (miR)-182-5p is recognized as a potential predictive biomarker for the early recurrence of HCC (12). Currently, DNA microarray approach has been used to investigate the genetic features of HCC in molecular biology (13).…”

Section: Introductionmentioning

confidence: 99%

Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy

et al. 2019

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Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of prognosis-associated biomarkers is crucial to improve HCC patient survival. The present study aimed to explore potential predictive biomarkers for HCC. Differentially expressed genes (DEGs) were analyzed in the GSE36376 dataset using GEO2R. Hub genes were identified and further investigated for prognostic value in HCC patients. A risk score model and nomogram were constructed to predict HCC prognosis using the prognosis-associated genes and clinical factors. Pearson's correlation was employed to show interactions among hub genes. Gene enrichment analysis was performed to identify detailed biological processes and pathways. A total of 71 DEGs were obtained and seven (ADH4, CYP2C8, CYP2C9, CYP8B1, SLC22A1, TAT and HSD17B13, all adjusted P≤0.05) of the 10 hub genes were identified as prognosis-related genes for survival analysis in HCC patients, including alcohol dehydrogenase 4 (class II), pi polypeptide (ADH4), cytochrome p450 family 2 subfamily C member 8 (CYP2C8), cytochrome P450 family 2 subfamily C member 9 (CYP2C9), cytochrome P450 family 8 subfamily B member 1 (CYP8B1), solute carrier family 22 member 1 (SLC22A1), tyrosine aminotransferase (TAT) and hydroxysteroid 17-β dehydrogenase 13 (HSD17B13). The risk score model could predict HCC prognosis and the nomogram visualized gene expression and clinical factors of probability for HCC prognosis. The majority of genes showed significant Pearson's correlations with others (41 Pearson correlations P≤0.01, four Pearson correlations P>0.05). GO analysis revealed that terms such as ‘chemical carcinogenesis’ and ‘drug metabolism-cytochrome P450’ were enriched and may prove helpful to elucidate the mechanisms of hepatocarcinogenesis. Hub genes ADH4, CYP2C8, CYP2C9, CYP8B1, SLC22A1, TAT and HSD17B13 may be useful as predictive biomarkers for HCC prognosis.

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Correction to: miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a

Cited by 21 publications

References 1 publication

Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)‐182/miR‐93‐leukemia inhibitory factor receptor pathway

Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)‐182/miR‐93‐leukemia inhibitory factor receptor pathway

miR-182-5p affects human bladder cancer cell proliferation, migration and invasion through regulating Cofilin 1

Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy

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