Correction to: Les misérables: A Parallel Between Antimicrobial Resistance and COVID‑19 in Underdeveloped and Developing Countries

Jorge, Genesy Pérez; Goes, Isabella Carolina Rodrigues dos Santos; Gontijo, Marco Túlio Pardini

doi:10.1007/s11908-022-00791-4

Cited by 5 publications

(8 citation statements)

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“…Durante a pandemia, o uso dos antibióticos de forma empírica e indiscriminada foi frequente em instituições de saúde e comunidades. Alguns autores descreveram que a maioria dos pacientes hospitalizados com COVID-19 foram submetidos à antibioticoterapia mesmo na ausência de infecções bacterianas (Zhou, et al, 2020;Firth & Prathapan, 2020;Huang, et al, 2020;Russell, et al, 2021;Jorge, et al, 2022). Da mesma forma, outro estudo, ao analisar 925 pacientes em hospitais holandeses, constatou que 556 pacientes (60,1%) receberam antibioticoterapia, mas apenas 12 pacientes (1,2%) tiveram coinfecção bacteriana (Karami, et al, 2021).…”

Section: Discussionunclassified

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Ribeiro

Torres

Rodrigues

et al. 2022

RSD

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Introdução: A resistência bacteriana descrita para o grupo ESKAPE é uma problemática considerável para a saúde global que resulta em prejuízos sociais, econômicos e principalmente a saúde. Objetivos: Descrever os prejuízos associados à saúde de pacientes internados com complicações da COVID-19 inerentes as coinfecções causadas pelo grupo bacteriano ESKAPE. Metodologia: Trata-se de uma revisão integrativa da literatura, as buscas dos estudos foram realizadas nas bases National Library of Medicine National Institutes of Health (PubMed) e Science Direct, utilizando o método PRISMA, foram incluídos artigos publicados entre os anos de 2020 e 2021, em inglês. Resultados: A amostra contou com 17 artigos, nos quais detectou-se a ocorrência do grupo ESKAPE e prejuízos inerentes à saúde dos pacientes com COVID-19. O Staphylococcus aureus sensível à meticilina (MSSA), seguido pelo Staphylococcus aureus resistente à meticilina (MRSA), Klebsiella pneumoniae e Enterococcus spp. foram as principais bactérias relatadas. Os principais prejuízos inerentes a associação COVID-ESKAPE foram o tempo prolongado de internação, a resistência bacteriana aos antimicrobianos e pior prognóstico. Conclusão: Portanto, a associação entre a presença de bactérias do grupo ESKAPE e os prejuízos inerentes à saúde de pacientes com COVID-19 não podem ser subestimadas. Faz-se necessário dar seguimento com novos estudos, a fim de prevenir agravos e promover saúde com base nas informações sobre as principais complicações, promovendo intervenções e reduzindo a morbimortalidade desses pacientes.

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Section: Discussionunclassified

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Ribeiro

Torres

Rodrigues

et al. 2022

RSD

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“…Устойчивость бактериальной флоры к противомикробным препаратам, возникающая на фоне терапии антибиотиками (АБ), становится одной из значимых проблем медицины XXI в. На распространение устойчивых бактерий во время пандемии влияют такие факторы, как чрезмерное назначение АБ, самолечение и отсутствие диаг ностических тестов для определения конкретной причины заболевания [1,2].…”

Section: введение антибиотикорезистентностьunclassified

“…Результаты, полученные C. Murray и соавт., указывают на то, что 4,95 млн смертей во всем мире за 2019 г. связаны наличием АБР бактерий к назначаемым АБ [5]. Специалисты Всемирной организации здравоохранения и многочисленные исследователи также подчеркивают, что распространение АБР к противомикробным препаратам является актуальной проблемой, требующей глобального, скоординированного алгоритма действий, направленных на решение складывающейся ситуации [1,[6][7][8][9].…”

Section: введение антибиотикорезистентностьunclassified

Study of the resistome of human microbial communities using a targeted panel of antibiotic resistance genes in COVID-19 patients

Yanushevich

2023

Terapevticheskii arkhiv

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Aim. To study overall drug resistance genes (resistome) in the human gut microbiome and the changes in these genes during COVID-19 in-hospital therapy. Materials and methods. A single-center retrospective cohort study was conducted. Only cases with laboratory-confirmed SARS-CoV-2 RNA using polymerase chain reaction in oro-/nasopharyngeal swab samples were subject to analysis. The patients with a documented history of or current comorbidities of the hepatobiliary system, malignant neoplasms of any localization, systemic and autoimmune diseases, as well as pregnant women were excluded. Feces were collected from all study subjects for subsequent metagenomic sequencing. The final cohort was divided into two groups depending on the disease severity: mild (group 1) and severe (group 2). Within group 2, five subgroups were formed, depending on the use of antibacterial drugs (ABD): group 2A (receiving ABD), group 2AC (receiving ABD before hospitalization), group 2AD (receiving ABD during hospitalization), group 2AE (receiving ABD during and before hospitalization), group 2B (not receiving ABD). Results. The median number of antibiotic resistance (ABR) genes (cumulative at all time points) was significantly higher in the group of patients treated with ABD: 81.0 (95% CI 73.8–84.5) vs. 51.0 (95% CI 31.1–68.4). In the group of patients treated with ABD (2A), the average number of multidrug resistance genes (efflux systems) was significantly higher than in controls (group 2B): 47.0 (95% CI 46.0–51.2) vs. 21.5 (95% CI 7.0–43.9). Patients with severe coronavirus infection tended to have a higher median number of ABR genes but without statistical significance. Patients in the severe COVID-19 group who did not receive ABD before and during hospitalization also had more resistance genes than the patients in the comparison group. Conclusion. This study demonstrated that fewer ABR genes were identified in the group with a milder disease than in the group with a more severe disease associated with more ABR genes, with the following five being the most common: SULI, MSRC, ACRE, EFMA, SAT.

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“…The most recent antimicrobialresistance report shows that among the bacterial species commonly associated with deadly diseases due to multidrug resistance, more than half are Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Salmonella enterica, accounting for nearly three million deaths worldwide in 2019, which corresponds to about 60 % of the total deaths associated with MDR [1]. MDR bacteria have threatened public health, especially in poor and lower-to-middle-income countries [2,3].…”

Section: Introductionmentioning

confidence: 99%

Combined effect of SAR-endolysin LysKpV475 with polymyxin B and Salmonella bacteriophage phSE-5

Gontijo,

Pereira Teles,

Martins Correia

et al. 2024

Microbiology

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Endolysins are bacteriophage (or phage)-encoded enzymes that catalyse the peptidoglycan breakdown in the bacterial cell wall. The exogenous action of recombinant phage endolysins against Gram-positive organisms has been extensively studied. However, the outer membrane acts as a physical barrier when considering the use of recombinant endolysins to combat Gram-negative bacteria. This study aimed to evaluate the antimicrobial activity of the SAR-endolysin LysKpV475 against Gram-negative bacteria as single or combined therapies, using an outer membrane permeabilizer (polymyxin B) and a phage, free or immobilized in a pullulan matrix. In the first step, the endolysin LysKpV475 in solution, alone and combined with polymyxin B, was tested in vitro and in vivo against ten Gram-negative bacteria, including highly virulent strains and multidrug-resistant isolates. In the second step, the lyophilized LysKpV475 endolysin was combined with the phage phSE-5 and investigated, free or immobilized in a pullulan matrix, against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 13311. The bacteriostatic action of purified LysKpV475 varied between 8.125 μg ml−1 against Pseudomonas aeruginosa ATCC 27853, 16.25 μg ml−1 against S. enterica Typhimurium ATCC 13311, and 32.50 μg ml−1 against Klebsiella pneumoniae ATCC BAA-2146 and Enterobacter cloacae P2224. LysKpV475 showed bactericidal activity only for P. aeruginosa ATCC 27853 (32.50 μg ml−1) and P. aeruginosa P2307 (65.00 μg ml−1) at the tested concentrations. The effect of the LysKpV475 combined with polymyxin B increased against K. pneumoniae ATCC BAA-2146 [fractional inhibitory concentration index (FICI) 0.34; a value lower than 1.0 indicates an additive/combined effect] and S. enterica Typhimurium ATCC 13311 (FICI 0.93). A synergistic effect against S. enterica Typhimurium was also observed when the lyophilized LysKpV475 at ⅔ MIC was combined with the phage phSE-5 (m.o.i. of 100). The lyophilized LysKpV475 immobilized in a pullulan matrix maintained a significant Salmonella reduction of 2 logs after 6 h of treatment. These results demonstrate the potential of SAR-endolysins, alone or in combination with other treatments, in the free form or immobilized in solid matrices, which paves the way for their application in different areas, such as in biocontrol at the food processing stage, biosanitation of food contact surfaces and biopreservation of processed food in active food packing.

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Correction to: Les misérables: A Parallel Between Antimicrobial Resistance and COVID‑19 in Underdeveloped and Developing Countries

Cited by 5 publications

References 0 publications

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Study of the resistome of human microbial communities using a targeted panel of antibiotic resistance genes in COVID-19 patients

Combined effect of SAR-endolysin LysKpV475 with polymyxin B and Salmonella bacteriophage phSE-5

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