Correction to: False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use

Arnal, María José Domper; Mateo, Sandra García; Hermoso-Durán, Sonia; Abad, David Gutiérrez; Carrera‐Lasfuentes, Patricia; Velázquez‐Campoy, Adrián; Franco, O Abian; Lanas, Ángel

doi:10.1007/s00384-021-03965-z

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“…For example, intake of proton pump inhibitors (PPIs) has been suggested to be associated with reduced accuracy of FIT by some [23,24] but not all [25] studies. Furthermore, interactions with sex or intake of other drugs have been suggested [26].…”

Section: Discussionmentioning

confidence: 99%

Consistent Major Differences in Sex- and Age-Specific Diagnostic Performance among Nine Faecal Immunochemical Tests Used for Colorectal Cancer Screening

Gies

Niedermaier

Alwers

et al. 2021

Cancers

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Evidence on diagnostic performance of faecal immunochemical tests (FITs) by sex and age is scarce. We aimed to evaluate FIT performance for detection of advanced colorectal neoplasia (AN) by sex and age across nine different FIT brands in a colonoscopy-controlled setting. The faecal samples were obtained from 2042 participants of colonoscopy screening. All eligible cases with AN (n = 216) and 300 randomly selected participants without AN were included. Diagnostic performance for detection of AN was assessed by sex and age (50–64 vs. 65–79 years for each of the nine FITs individually and for all FITs combined. Sensitivity was consistently lower, and specificity was consistently higher for females as compared with males (pooled values at original FIT cutoffs, 25.7% vs. 34.6%, p = 0.12 and 96.2% vs. 90.8%, p < 0.01, respectively). Positive predictive values (PPVs) were similar between both sexes, but negative predictive values (NPVs) were consistently higher for females (pooled values, 91.8% vs. 86.6%, p < 0.01). Sex-specific cutoffs attenuated differences in sensitivities but increased differences in predictive values. According to age, sensitivities and specificities were similar, whereas PPVs were consistently lower and NPVs were consistently higher for the younger participants. A negative FIT is less reliable in ruling out AN among men than among women and among older than among younger participants. comparisons of measures of diagnostic performance among studies with different sex or age distributions should be interpreted with caution.

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