Correction to: Efficacy of intravenous plus intrathecal/intracerebral ventricle injection of polymyxin B for post-neurosurgical intracranial infections due to MDR/XDR Acinectobacter baumannii: a retrospective cohort study

Pan, Sijun; Huang, Xiaofang; Wang, Yesong; Li, Li; Zhao, Changyun; Yao, Zhong-Xiang; Cui, Wei; Zhang, Gensheng

doi:10.1186/s13756-019-0462-1

Cited by 3 publications

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“…Currently, there is limited experience with ITH/ITV polymyxin B. Pan et al reported that ITH/ITV polymyxin B has a good clinical effect on XDR A. baumannii intracranial infection, with a mortality rate of only 8.70%, and no cases of acute kidney injury or neurotoxicity were observed among the study participants. 34 Therefore, it can be seen that polymyxin B is relatively safe. In addition, there are other small sample studies that have confirmed the same efficacy of polymyxin B 35–40 ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…Only one patient reported mild neurotoxicity. 34–40 Therefore, the exact mechanism of polymyxin B nephrotoxicity and neurotoxicity are still under study. Therefore, close monitoring of renal function, more careful management of fluids and electrolytes, and avoiding the use of other drugs known to have nephrotoxicity may reduce the incidence of related side effects.…”

Section: Discussionmentioning

confidence: 99%

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Intrathecal Injection of Tigecycline and Polymyxin B in the Treatment of Extensively Drug-Resistant Intracranial Acinetobacter baumannii Infection: A Case Report and Review of the Literature

Li¹,

An²,

Li³

et al. 2022

IDR

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Purpose Intracranial infection after neurosurgery is one of the most serious complications, especially extensively drug-resistant (XDR) Acinetobacter baumannii ( A. baumannii ) seriously affects the prognosis of patients. At present, there is little experience in the treatment of this infection and limited effective treatment options, like tigecycline or polymyxin B. Therefore, this report aims to describe the efficacy of tigecycline combined with polymyxin B by intrathecal (ITH) injection in the treatment of XDR intracranial infection with A. baumannii . Methods We report a case of intracranial infection with XDR A. baumannii after ventricular drainage, treated by daily ITH and intravenous (IV) tigecycline, combined with polymyxin B ITH route. Moreover, tigecycline and polymyxin B treatments for XDR intracranial infection with A. baumannii that were reported in the literature were also reviewed and summarized. Results The white blood cells (WBCs) of the patient’s cerebrospinal fluid dropped to normal, and the symptoms of intracranial infection disappeared. The patient finally obtained good clinical results and transferred to the local hospital. Conclusion The polymyxin B ITH route is an ideal treatment strategy for XDR A. baumannii . The IV plus ITH tigecycline may be an effective treatment option. However, more researches should be conducted to confirm our observation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%