Correction to: Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit, Léna; Vernès, Léa; Cadoret, Jean‐Paul

doi:10.1007/s10811-021-02476-2

Cited by 2 publications

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“…The molecular docking results were tested on two different docking tools; Autodock Vina and SwissDock Softwares. The up-to-date corrected results by Petit et al [112] are in the following: PEB (−7.45 ± 0.05 kcal.mol −1 Autodock Vina (VS) −10.35 ± 0.00 kcal.mol −1 SwissDock) PCB (−7.25 ± 0.15 kcal.mol −1 Autodock Vina (VS) -9.35 ± 0.025 kcal.mol −1 SwissDock), and lastly Phycourobilin (−7.1 ± 0.00 kcal.mol −1 Autodock Vina (VS) −9.285 ± 0.425 kcal.mol −1 SwissDock). The author assessed their toxicity using an in silico toxicity analysis tool and reported that all the mentioned compounds are safe and have high oral bioavailability.…”

Section: Sars-cov-2/covid-19mentioning

confidence: 98%

Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes

et al. 2022

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Arthrospira platensis (A. platensis) aqueous extract has massive amounts of natural products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc. This extract was chosen because of its high adaptability, which reflects its resolute genetic composition. The proactive roles of cyanobacteria, particularly in the medical field, have been discussed in this review, including the history, previous food and drug administration (FDA) reports, health benefits and the various dosedependent therapeutic functions that A. platensis possesses, including its role in fighting against lethal diseases such as cancer, SARS-CoV-2/COVID-19, etc. However, the remedy will not present its maximal effect without the proper delivery to the targeted place for deposition. The goal of this research is to maximize the bioavailability and delivery efficiency of A. platensis constituents through selected sites for effective therapeutic outcomes. The solutions reviewed are mainly on parenteral and tablet formulations. Moreover, suggested enteric polymers were discussed with minor composition variations applied for better storage in high humid countries alongside minor variations in the polymer design were suggested to enhance the premature release hindrance of basic drugs in low pH environments. In addition, it will open doors for research in delivering active pharmaceutical ingredients (APIs) in femtoscale with the use of various existing and new formulations.

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Section: Sars-cov-2/covid-19mentioning

confidence: 98%

Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes

et al. 2022

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Comparative In-Silico Molecular Docking of Silymarin for SARS-CoV-2 Receptor

2022

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COVID-19 pandemic has spread across the world in over 185 countries, with millions of infections and hundreds of thousands of deaths. The current pandemic has made the situation worse, forcing the development of better treatment. In this work, the binding ability of covid receptors with silymarin has been analyzed using AutoDock 1.4.6. Further, it is compared with the standard drug remdesivir. Silymarin, a potential phytochemical compound obtained from the seeds of the Silybum marianum (milk thistle) plant, has been documented as the antiviral agent against several viruses. So silymarin can also be an effective compound in the treatment of COVID-19. This study aims to determine the binding ability of COVID-19 receptors towards silymarin and further comparative analysis by remdesivir. Drug Discovery Studio version 2021 software was been used to analyse ligand and target. AutoDock 1.4.6 software was used to perform the docking study. Among the various receptors, 5N11 (Human beta1-coronavirus (β1CoV) OC43), 7MJP (SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-39), 7JMO (SARS-CoV-2 receptor-binding domain in complex with neutralizing antibody COVA2-04) receptors showed the highest binding ability of -8.09, -7.23, -6.96 towards silymarin compared to the standard remdesivir having the docking score of -5.21, -3.76, -2.97, respectively. By the comparative analysis, silymarin has a better and highest binding ability.

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Correction to: Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Cited by 2 publications

References 0 publications

Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes

Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes

Comparative In-Silico Molecular Docking of Silymarin for SARS-CoV-2 Receptor

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