Correction to Biomimetic Monolayer and Bilayer Membranes Made From Amphiphilic Block Copolymer Micelles

Goertz, Matthew P.; Marks, Lauryn E.; Montaño, Gabriel A.

doi:10.1021/nn3028634

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“…The natural solution to this puzzle was to explore the adsorption behavior of polymer and hybrid vesicles as a function of pH. Using vesicles with a range in composition from pure DOPC to pure EO 22 Bd 33 (10,25,50,75, and 100 mol % polymer) we probed the interaction of hybrid vesicles with glass under varying pH conditions (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) by measuring changes in frequency and dissipation (Figure 4). We first compared QCM-D data from hybrid vesicles interacting with glass at pH = 2 to the results obtained at pH = 7 (see above).…”

Section: Behavior Of Lipid Polymer and Hybrid Vesicles Over A Ph Rangementioning

confidence: 99%

“…Generating supported polymer bilayers and supported hybrid lipid/polymer bilayers (SHBs) offers another practical approach towards robust and stable biomimetic platforms. Indeed, there is a growing interest in understanding and exploiting the formation of SHB films in the past few years [22][23][24][25][26][27], including the use of amphiphilic polymers to complement the library of conventional lipids. Such hybrid materials have recently been highlighted as an important development toward biomimetic interfaces [28,29].…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Lipid-Polymer Bilayers: pH-Mediated Interactions between Hybrid Vesicles and Glass

2020

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One practical approach towards robust and stable biomimetic platforms is to generate hybrid bilayers that incorporate both lipids and block co-polymer amphiphiles. The currently limited number of reports on the interaction of glass surfaces with hybrid lipid and polymer vesicles-DOPC mixed with amphiphilic poly(ethylene oxide-b-butadiene) (PEO-PBd)-describe substantially different conclusions under very similar conditions (i.e., same pH). In this study, we varied vesicle composition and solution pH in order to generate a broader picture of spontaneous hybrid lipid/polymer vesicle interactions with rigid supports. Using quartz crystal microbalance with dissipation (QCM-D), we followed the interaction of hybrid lipid-polymer vesicles with borosilicate glass as a function of pH. We found pH-dependent adsorption/fusion of hybrid vesicles that accounts for some of the contradictory results observed in previous studies. Our results show that the formation of hybrid lipid-polymer bilayers is highly pH dependent and indicate that the interaction between glass surfaces and hybrid DOPC/PEO-PBd can be tuned with pH.

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Section: Behavior Of Lipid Polymer and Hybrid Vesicles Over A Ph Rangementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hybrid Lipid-Polymer Bilayers: pH-Mediated Interactions between Hybrid Vesicles and Glass

2020

View full text Add to dashboard Cite

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Correction to Biomimetic Monolayer and Bilayer Membranes Made From Amphiphilic Block Copolymer Micelles

Cited by 1 publication

References 0 publications

Hybrid Lipid-Polymer Bilayers: pH-Mediated Interactions between Hybrid Vesicles and Glass

Hybrid Lipid-Polymer Bilayers: pH-Mediated Interactions between Hybrid Vesicles and Glass

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