Correction to “Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes”

Sreij, Ramsia; Dargel, Carina; Moleiro, Lara H.; Monroy, Francisco; Hellweg, Thomas

doi:10.1021/acs.langmuir.7b03917

Cited by 3 publications

(9 citation statements)

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“…Upon rising the β-aescin content to values higher than ≈1 mol%, β-aescin incorporation increases the effect of phase separation inside the lipid bilayer. This shows clearly in the endotherms measured by differential scanning calorimetry (DSC) ( Figure 10) and was moreover confirmed by wide-angle X-ray scattering (WAXS) experiments [46]. The formation of saponin-poor and saponin-rich domains becomes obvious in the presented data and is expressed by the rising intensity of the peak at lower temperature.…”

Section: β-Aescin Interaction With Bare Lipid Model Membranessupporting

confidence: 72%

“…The interaction of β-aescin with bare lipid model membranes from the physicochemical perspective is subject of works published over the last 2 years by Sreij et al [46][47][48] and Geisler et al [49]. The work is done exemplarily on phospholipid bilayers composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) at constant environmental conditions, i.e., in 50 mM phosphate buffer at physiological p(H)≈ p(D) of about 7.4 and a DMPC mass concentration of w(DMPC) = 15 mg/mL.…”

Section: β-Aescin Interaction With Bare Lipid Model Membranesmentioning

confidence: 99%

“…For β-aescin, the bilayer bending modulus κ depends on β-aescin concentration and lipid phase state. For the phospholipid DMPC, the main phase transition occurs at a temperature of T m =23.6 • C [46]. In the gel phase of DMPC, i.e., at 10 • C, the interactions of β-aescin with the bilayer lower the bending modulus and the membrane softens in a concentration-dependent manner (Figure 9).…”

Section: β-Aescin Interaction With Bare Lipid Model Membranesmentioning

confidence: 99%

Section: Interaction Of β-Aescin With Langmuir Monolayers From Langmumentioning

confidence: 99%

“…Up to now, there are only a few reports on the effect of β-aescin on a DMPC monolayer [39,46]. Sreij et al [46] studied the penetration effect of β-aescin into a DMPC monolayer by subphase exchange experiments. Thereby, the DMPC monolayer was adsorbed at the buffer-air interface and was studied in either the liquid condensed (LC) or liquid expanded (LE) phase at 4 • C or 38 • C, respectively.…”

Section: Interaction Of β-Aescin With Langmuir Monolayers From Langmumentioning

confidence: 99%

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The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

2019

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This review discusses recent progress in physicochemical understanding of the action of the saponin β -aescin (also called β -escin), the biologically active component in the seeds of the horse chestnut tree Aesculus hippocastanum. β -Aescin is used in pharmacological and cosmetic applications showing strong surface activity. In this review, we outline the most important findings describing the behavior of β -aescin in solution (e.g., critical micelle concentration ( c m c ) and micelle shape) and special physicochemical properties of adsorbed β -aescin monolayers at the air–water and oil–water interface. Such monolayers were found to posses very special viscoelastic properties. The presentation of the experimental findings is complemented by discussing recent molecular dynamics simulations. These simulations do not only quantify the predominant interactions in adsorbed monolayers but also highlight the different behavior of neutral and ionized β -aescin molecules. The review concludes on the interaction of β -aescin with phospholipid model membranes in the form of bilayers and Langmuir monolayers. The interaction of β -aescin with lipid bilayers was found to strongly depend on its c m c . At concentrations below the c m c , membrane parameters are modified whereas above the c m c , complete solubilization of the bilayers occurs, depending on lipid phase state and concentration. In the presence of gel-phase phospholipids, discoidal bicelles form; these are tunable in size by composition. The phase behavior of β -aescin with lipid membranes can also be modified by addition of other molecules such as cholesterol or drug molecules. The lipid phase state also determines the penetration rate of β -aescin molecules into lipid monolayers. The strongest interaction was always found in the presence of gel-phase phospholipid molecules.

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Section: β-Aescin Interaction With Bare Lipid Model Membranessupporting

confidence: 72%

Section: β-Aescin Interaction With Bare Lipid Model Membranesmentioning

confidence: 99%

Section: β-Aescin Interaction With Bare Lipid Model Membranesmentioning

confidence: 99%

Section: Interaction Of β-Aescin With Langmuir Monolayers From Langmumentioning

confidence: 99%

Section: Interaction Of β-Aescin With Langmuir Monolayers From Langmumentioning

confidence: 99%

See 3 more Smart Citations

The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

2019

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Correction to “Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes”

Sreij¹,

Dargel²,

Moleiro³

et al. 2017

Langmuir

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Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

et al. 2020

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β -aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β -aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β -aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.

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Correction to “Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes”

Cited by 3 publications

References 1 publication

The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

Correction to “Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes”

Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

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