Correction to: A Novel Eutectic-Based Transdermal Delivery System for Risperidone

Al-Akayleh, Faisal; Adwan, Samer; Khanfar, Mai; Idkaidek, Nasir; Al-Remawi, Mayyas

doi:10.1208/s12249-020-01903-w

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The eutectic system is a mixture of two or more substances formed by entropy changes associated with both hydrogen bonds and van der Waals forces. These interactions result in a mutual decrease in the melting point of the mixture with respect to each of its individual components. ,, The pro-drug technique is based on the modification of a substance’s active molecules by attaching a lipophilic group, such as an ester group, to create a compound that is more easily partitioned between the SC and the pharmaceutical formulation causing a change in the partition coefficient (LogP). − The so-called ion-pair technique which involves neutralization of the electrical charge of the active substance by through formation its salt is also used. − Supersaturated systems allow for faster transdermal penetration of the drug, as they have increased thermodynamic activity …”

Section: Introductionmentioning

confidence: 99%

“…These interactions result in a mutual decrease in the melting point of the mixture with respect to each of its individual components. 11 , 27 , 28 The pro-drug technique is based on the modification of a substance’s active molecules by attaching a lipophilic group, such as an ester group, to create a compound that is more easily partitioned between the SC and the pharmaceutical formulation causing a change in the partition coefficient (LogP). 29 − 32 The so-called ion-pair technique which involves neutralization of the electrical charge of the active substance by through formation its salt is also used.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Natural Ingredients of Transdermal Drug Delivery Systems as Permeation Enhancers of Active Substances through the Stratum Corneum

et al. 2023

View full text Add to dashboard Cite

In recent years, significant progress has been made in transdermal drug delivery systems, but there is still a search for enhancers that can improve the absorption of active substances through the stratum corneum. Although permeation enhancers have been described in the scientific literature, the use of naturally occurring substances in this role is still of particular interest, because they can offer a high level of safety of use, with a low risk of skin irritation, and high efficiency. In addition, these ingredients are biodegradable, easily available, and widely accepted by consumers due to the growing trust in natural compounds. This article provides information on the role of naturally derived compounds in transdermal drug delivery systems that help them penetrate the skin. The work focuses on the components found in the stratum corneum such as sterols, ceramides, oleic acid, and urea. Penetration enhancers found in nature, mainly in plants, such as terpenes, polysaccharides, and fatty acids have also been described. The mechanism of action of permeation enhancers in the stratum corneum is discussed, and information on the methods of assessing their penetration efficiency is provided. Our review mainly covers original papers from 2017 to 2022, supplemented with review papers, and then older publications used to supplement or verify the data. The use of natural penetration enhancers has been shown to increase the transport of active ingredients through the stratum corneum and can compete with synthetic counterparts.

show abstract