Deep eutectic liquid as transdermal delivery vehicle of Risperidone

Structural insights into novel therapeutic deep eutectic systems with capric acid using 1D, 2D NMR and DSC techniques with superior gut permeability

“…As mentioned earlier, a notable observation was that both Drp and Arp are both GFA Class II drugs, 52 as evidence by their failure to recrystallise on cooling at the cooling rate of 10 °C min −1 used throughout the DSC experiments. Similar observations have been previously reported, 18,25,55 indicating some correlation between the ability of a drug to form a THEDES and its GFA class. More specically, since the GFA class is a proxy for crystal strength, 52 there seems to be a correlation between the crystal strength of a drug and its ability to form THEDES.…”

Formulation of Gelled Microemulsion for Effective Permeation of Celecoxib Across the Skin Barrier

“…In addition, μEG designs can control the mobility and localization of the drug and can also translate its affinity to diffusion into the stratum corneum [45] . CXB aggregates encapsulated in the lipophilic environment of μE (olive oil globules) are responsible for the significant passage of CXB from stratum corneum lipids [3a,32,46] . However, improved retention and sustained release of CXB due to the high viscosity and dynamics of μEG formulation [4a,44] …”

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

“…Cholinium-based ILs with different anions showed different solubility enhancement ratios for naproxen and ibuprofen [121] . The solubility of risperidone, a hydrophobic drug, was improved using ILs containing menthol and capsaicin, which was increased with increased capsaicin content [101] . Wu et al studied the solubility of ketoconazole, a hydrophobic drug, in ILs with different carboxylic and amino acids.…”