Correction: Schütt et al. Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model. Pharmaceutics 2022, 14, 184

Schütt, Michael; O’Farrell, Connor; Stamatopoulos, Konstantinos; Hoad, Caroline L.; Marciani, Luca; Sulaiman, Sarah; Simmons, Mark; Batchelor, Hannah; Alexiadis, Alessio

doi:10.3390/pharmaceutics14071402

Cited by 4 publications

(1 citation statement)

References 2 publications

(1 reference statement)

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“…Because the geometry can deform, this approximates the physiological conditions. However, as the pressure values in these studies reflect the total pressure increase rather than the active pressure that causes motility, we adjusted the inlet pressure based on MRI-based velocity measurements and the total mass accumulation at the outlet (47,48).…”

Section: Intestinal Motility Specificationmentioning

confidence: 99%

Computational Insights into Colonic Motility: Mechanical Role of Mucus in Homeostasis and Inflammation

Erbay,

Alexiadis,

Rochev

2023

Preprint

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Colonic motility plays a vital role in maintaining proper digestive function. The rhythmic contractions and relaxations facilitate various types of motor functions that generate both propulsive and non-propulsive motility modes which in turn generate shear stresses on the epithelial surface. However, the interplay between colonic mucus, shear stress, and epithelium remains poorly characterized. Here, we present a colonic computational model that describes the potential roles of mucus and shear stress in both homeostasis and ulcerative colitis (UC). Our model integrates several key features, including the properties of the mucus bilayer and lumen contents, colonic pressure, and crypt characteristics to predict the time-space mosaic of shear stress. We show that the mucus thickness which could vary based on the severity of UC, may significantly reduce the amount of shear stress applied to the colonic crypts and effect colonic content velocity. Our model also reveals an important spatial shear stress variance in homeostatic colonic crypts that suggests shear stress may have a modulatory role in epithelial cell migration, differentiation, apoptosis, and immune surveillance. Together, our study uncovers the rather neglected roles of mucus and shear stress in intestinal cellular processes during homeostasis and inflammation.

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Section: Intestinal Motility Specificationmentioning

confidence: 99%

Computational Insights into Colonic Motility: Mechanical Role of Mucus in Homeostasis and Inflammation

Erbay,

Alexiadis,

Rochev

2023

Preprint

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Digital twin in healthcare: Recent updates and challenges

Sun

2023

DIGITAL HEALTH

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As simulation is playing an increasingly important role in medicine, providing the individual patient with a customised diagnosis and treatment is envisaged as part of future precision medicine. Such customisation will become possible through the emergence of digital twin (DT) technology. The objective of this article is to review the progress of prominent research on DT technology in medicine and discuss the potential applications and future opportunities as well as several challenges remaining in digital healthcare. A review of the literature was conducted using PubMed, Web of Science, Google Scholar, Scopus and related bibliographic resources, in which the following terms and their derivatives were considered during the search: DT, medicine and digital health virtual healthcare. Finally, analyses of the literature yielded 465 pertinent articles, of which we selected 22 for detailed review. We summarised the application examples of DT in medicine and analysed the applications in many fields of medicine. It revealed encouraging results that DT is being increasing applied in medicine. Results from this literature review indicated that DT healthcare, as a key fusion approach of future medicine, will bring the advantages of precision diagnose and personalised treatment into reality.

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