Correction: Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D <i>in vitro</i> platform

Goodarzi, Saba; Prunet, Audrey; Rossetti, Fabien; Bort, Guillaume; Tillement, Olivier; Porcel, Erika; Lacombe, S.; Wu, Ting-Di; Guerquin‐Kern, Jean‐Luc; Delanoë-Ayari, Hélène; Lux, François; Rivière, Charlotte

doi:10.1039/d1lc90127c

Cited by 1 publication

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“…Cellular spheroids have emerged as alternative in vitro models to 2D cultures as they integrate the 3D geometry of the physiological environment. These spheroids can for instance be used to screen drugs[92], and a first necessary step for their formation is the gathering of cells in close contact to each other. The immediate application of the 3D magnetic patterning is to maintain, for several hours or days, a large number of cells in a well-defined region of space by transient application of an external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Magnetic bioprinting of stem cell-based tissues

Walle

Perez

Wilhelm

2022

Preprint

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An attractive approach in cell therapies and medically oriented nanotechnologies is to interface magnetic nanoparticles with cells. This will supply the cells with sufficient magnetization for theranostic applications and for external magnetic field manipulation. In tissue engineering, one challenge is to produce tissue analogues that are large, precisely organized, and responsive to stimuli, preferably without the need for an artificial supporting scaffold. One powerful tool for such biofabrication is certainly the bioprinting technology. In magnetic tissue engineering, it appears possible to use magnetic forces to manipulate cells, both individually and within aggregates, and thereby to produce three-dimensional artificial tissues with inherent capacities for further physical stimulation, a possibility that bioprinting does not offer yet. We here introduce the feasibility of using magnetic forces created by external (micro)magnets to form 3D tissue-like scaffold-free structures. Because stem cells are essential in tissue engineering, such magnetic technologies were developed with magnetized stem cells, and applied for instance to vascular or cartilage tissue engineering. One precondition to this approach, which lies in the magnetization of (stem) cells endowed through internalization of iron oxide magnetic nanoparticles, is to ensure the safety of magnetic nanoparticles with respect to cellular functions, which is initially discussed. Finally, we introduce a magnetic tissue stretcher which, in a single step, allows to create a tissue composed of any type of component cell, then to mature it, stimulate it by compression or stretching at any desired frequency, e.g. cyclically, opening new possibilities in the cardiac muscle tissue engineering field.

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Section: Introductionmentioning

confidence: 99%