Correction: Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring

Sabet, Julia A.; Park, Lara K.; Iyer, Lakshmanan K.; Tai, Albert; Koh, Gar Yee; Pfalzer, Anna C; Parnell, Laurence D.; Mason, Joel B.; Liu, Zhenhua; Byun, Alexander J.; Crott, Jimmy W.

doi:10.1371/journal.pone.0154979

Cited by 2 publications

(5 citation statements)

References 1 publication

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“…MTTP works to promote lipid transfer to apolipoprotein B within the ER, facilitating lipid export from hepatocytes, which may also account for triglyceride reduction in the folic acid group. A paternal dietary B vitamin difference could cause variance in hepatic total cholesterol, triglycerides, and lipid metabolism related gene expression of female offsprings . As for amino acid metabolism similarly altered by folic acid in the study, folic acid is involved in many functional pools such as purine synthesis, thymidylate synthesis, and homocysteine remethylation; and amino acids such glycine and serine all participate in the conversion process from 5,10-methylene THF to THF .…”

Section: Discussionmentioning

confidence: 88%

“…A paternal dietary B vitamin difference could cause variance in hepatic total cholesterol, triglycerides, and lipid metabolism related gene expression of female offsprings. 14 As for amino acid metabolism similarly altered by folic acid in the study, folic acid is involved in many functional pools such as purine synthesis, thymidylate synthesis, and homocysteine remethylation; and amino acids such glycine and serine all participate in the conversion process from 5,10-methylene THF to THF. 44 Thus, it is comprehensible that amino acid metabolic changes were found in the current study.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

“…13 Paternal dietary B vitamin difference could cause the variance in hepatic total cholesterol, triglyceride, and lipid metabolism gene expression of female offspring. 14 Folic acid, as a water-soluble B vitamin, is involved in one-carbon metabolism and has been also reviewed to have many potential mechanisms linking its deficiency to fatty liver disease. 15 Yu et al found that folic acid addition could reduce FAS and C/EBPα expression by changing the methylation level of gene promoters.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Dietary methyl donors could increase fatty acid utilization and prevent hepatic lipid accumulation in NAFLD by activating AMPK . Paternal dietary B vitamin difference could cause the variance in hepatic total cholesterol, triglyceride, and lipid metabolism gene expression of female offspring . Folic acid, as a water-soluble B vitamin, is involved in one-carbon metabolism and has been also reviewed to have many potential mechanisms linking its deficiency to fatty liver disease .…”

Section: Introductionmentioning

confidence: 99%

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Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes

Liu

Shen

Yang

et al. 2018

J. Agric. Food Chem.

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Abdominal fat or fatty liver cause huge economic losses in the poultry industry, and nonalcoholic fatty liver disease (NAFLD) is also a global health issue in humans. More than 90% of de novo lipogenesis in humans and chickens is undertaken by the liver, which is proved to be full of lipids in new-born chickens. Folic acid was thought to have correlation with lipid metabolism. Primary hepatocytes from new-born chickens were employed as a natural model of early stage fatty liver in vitro and further to explore whether folic acid could prevent fatty liver in the current study. We found that folic acid addition reduced triglyceride deposition by suppressing de novo fatty acid synthesis and coordinately promoting triglyceride hydrolysis and exportation in primary chicken hepatocytes from new-born chickens. In addition, lipogenesis suppression was through the PI3K/AKT/SREBP pathway mediated by weakening insulin/IGF signal. Our data suggested that folic acid may be considered as a precautionary strategy for abdominal fat deposition in broilers or fatty liver in laying hens and humans. In addition, mechanism regulation also implied that an IGF2 inhibitor and PI3K inhibitor may be used for the NAFLD precautionary measure to reduce TG deposition.

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Section: Discussionmentioning

confidence: 88%

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes

Liu

Shen

Yang

et al. 2018

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Based on the few associations we made between the methylation and transcription changes in grown offspring, it is also difficult to conclude on whether parental (F 0 ) diet influenced the environment of the developing embryo while priming hepatic gene expression of progeny [18, 33, 88]. Two studies in rodents could not link parental diet-associated DNA methylation changes with gene expression in the progeny [44, 89]. This underlines the need for more detailed knowledge on the complex link between nutrients and epigenetic modifications, for example, in the germline and early embryo resulting in altered gene expression and metabolic phenotypes in grown offspring [88].…”

Section: Discussionmentioning

confidence: 99%

Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid

et al. 2019

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Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and offspring. Diets enriched in omega-6 and deficient in omega-3 PUFAs (low dietary omega-3/omega-6 PUFA ratio), have been associated with the promotion of pathogenesis of diseases in humans and other mammals. In this study, we investigated the impact of increased dietary intake of arachidonic acid (ARA), a physiologically important omega-6 PUFA, on 2 generations of zebrafish. Parental fish were fed either a low or a high ARA diet, while the progeny of both groups were fed the low ARA diet. We screened for DNA methylation on single base-pair resolution using reduced representation bisulfite sequencing (RRBS). The DNA methylation profiling revealed significant differences between the dietary groups in both parents and offspring. The majority of differentially methylated loci associated with high dietary ARA were found in introns and intergenic regions for both generations. Common loci between the identified differentially methylated loci in F 0 and F 1 livers were reported. We described overlapping gene annotations of identified methylation changes with differential expression, but based on a small number of overlaps. The present study describes the diet-associated methylation profiles across genomic regions, and it demonstrates that parental high dietary ARA modulates DNA methylation patterns in zebrafish liver.

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Correction: Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring

Cited by 2 publications

References 1 publication

Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes

Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes

Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid

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