Correction of Endothelial Dysfunction in Patients with Arterial Hypertension

Soloviev, M. A.; Кулакова, Н. В.; Semiglazova, T. A.; Borodulina, E. V.; Удут, В. В.

doi:10.1007/s10517-011-1284-1

Cited by 10 publications

(11 citation statements)

References 3 publications

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“…Another study, with similar aspirin dosing and duration of treatment, showed improvement in flow-mediated dilation and decrease in C-reactive protein and intercellular adhesion molecules level with aspirin. However, due to the study design, it was impossible to reliably separate effects of aspirin from effects of concomitant treatments [89]. In another study, aspirin therapy resulted in improvement of flow-mediated dilation and blood pressure reduction, when combined with statins, while no significant dynamics was observed on aspirin monotherapy [90].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aspirin on Endothelial Function and Hypertension

2016

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Purpose of reviewEndothelial dysfunction is intimately related to the development of various cardiovascular diseases, including hypertension, and is often used as a target for pharmacological treatment. The scope of this review is to assess effects of aspirin on endothelial function and their clinical implication in arterial hypertension.Recent findingsEmerging data indicate the role of platelets in the development of vascular inflammation due to the release of proinflammatory mediators, for example, triggered largely by thromboxane. Vascular inflammation further promotes oxidative stress, diminished synthesis of vasodilators, proaggregatory and procoagulant state. These changes translate into vasoconstriction, impaired circulation and thrombotic complications. Aspirin inhibits thromboxane synthesis, abolishes platelets activation and acetylates enzymes switching them to the synthesis of anti-inflammatory substances.SummaryAspirin pleiotropic effects have not been fully elucidated yet. In secondary prevention studies, the decrease in cardiovascular events with aspirin outweighs bleeding risks, but this is not the case in primary prevention settings. Ongoing trials will provide more evidence on whether to expand the use of aspirin or stay within current recommendations.

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Section: Introductionmentioning

confidence: 99%

Effects of Aspirin on Endothelial Function and Hypertension

2016

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“…1: mais importante a condição funcional que idade cronológica; 2: incluindo fragilidade leve; 3: fragilidade moderada a severa; 4: incluindo idosos com comorbidades: DM, DAC, DRC, ACV/EIT (não se refere à fase aguda); 5: avaliar ativamente a tolerabilidade, inclusive possíveis sintomas atípicos; 6: umna meta mais rígida(125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135) pode ser obtida em casos selecionados, especialmente em idosos motivados, com < 80 anos, apresentando ótima tolerabilidade ao tratamento; 7: limites mais elevados em caso de sobrevida limitada e ausência de sintomas. A redução da PA deve ser gradual; 8: PAD = evitar < 65-70 mmHg em portadores de DAC clinicamente manifesta.Diretrizes Brasileiras de Hipertensão Arterial -2020 Barroso et al Arq Bras Cardiol.…”

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Diretrizes Brasileiras de Hipertensão Arterial – 2020

Barroso¹,

Rodrigues²,

Bortolotto³

et al. 2021

Arquivos Brasileiros De Cardiologia

588

202

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“…Flow-mediated dilation (FMD) of the brachial artery is an indirect non-invasive technique to assess endothelial function and is chie y dependent on NO availability (11). Since acute post-exercise changes in vascular function may also predict long-term adaptations (12) the acute response to exercise has been widely studied (3,13).…”

Section: Introductionmentioning

confidence: 99%

Effects of Autonomic Nervous System Activation on Endothelial Function in Response to Acute Exercise in Hypertensive Individuals: Study Protocol for A Randomized Double-Blind Study

Waclawovsky

Boll

Neto

et al. 2020

Preprint

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Background: Arterial hypertension has a direct association with endothelial dysfunction and major cardiovascular events. There is evidence showing the benefits of aerobic exercise on flow-mediated dilation (FMD) in hypertensive individuals but little is known about the effect of autonomic nervous system (ANS) activation on FMD of the brachial artery in response to different types of exercise in this specific population. This study aims to examine the effects of ANS activation on FMD of the brachial artery in response to exercise in hypertensive individuals following a session of different types of exercise including aerobic exercise (AE), resistance exercise (RE) or combined exercise (CE). Methods: Thirty-nine hypertensive volunteers aged 35 to 55 years will be randomly assigned to two exercise sessions: AE (40 minutes on a cycle ergometer at 60% of HR reserve); RE (4 lower limb sets with 12 repetitions at 60% 1-RM for 40 minutes) or CE (RE for 20 minutes + AE for 20 minutes). Each exercise group will be randomized to receive either an α1-adrenergic blocker (doxazosin 0.05 mg/kg-1) or placebo. Ultrasound measurement of FMD is performed 10 minutes before and 10, 40 and 70 minutes after exercise. ANS activation is monitored using a Finometer and measurements are taken during 10 minutes before each FMD assessment. Arterial stiffness is assessed by pulse wave velocity (PWV) analysis using a Complior device. Discussion: We expect to demonstrate the effect of ANS activation on FMD of the brachial artery in hypertensive individuals in response to different types of exercise. This study may give some insight on how to improve exercise prescription for hypertension management. Trial registration: www.clinicaltrials.gov (ID: NCT04371757).

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Correction of Endothelial Dysfunction in Patients with Arterial Hypertension

Cited by 10 publications

References 3 publications

Effects of Aspirin on Endothelial Function and Hypertension

Effects of Aspirin on Endothelial Function and Hypertension

Diretrizes Brasileiras de Hipertensão Arterial – 2020

Effects of Autonomic Nervous System Activation on Endothelial Function in Response to Acute Exercise in Hypertensive Individuals: Study Protocol for A Randomized Double-Blind Study

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