Correction of Aftereffects of Ionizing Radiation by Exposure to Low-Intensity Light

Bavrina, A. P.; Monich, V. A.; Malinovskaya, S. L.; Ermolaev, V. S.; Дружинин, Е. И.; Kuznetsov, S. А.

doi:10.1007/s10517-014-2420-5

Cited by 3 publications

(2 citation statements)

References 2 publications

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“… Asai et al [ 50 ] No info Source, LED; wavelength, 630 nm; power, –; frequency, –; beam area, – Irradiance, 20 mW/cm 2 ; time, –; energy, –; radiant exposure, 0.5–3 J/cm 2 Low-level red LED light can enhance MC3T3-E1 cell proliferation and osteogenic differentiation when the cells are cultured for a relatively long time. Bavrina et al [ 54 ] No info Source, –; wavelength, 356–530 nm; power, –; frequency, –; beam area, – Irradiance, –; time, 15 min; energy, radiant exposure, – Exposure to low-intensity incoherent red light after exposure to ionising radiation led to a decrease in the level of oxidative modification of protein and LPO products and diminished cellular manifestation of radiation sickness. Ko et al [ 55 ] No info Source, laser/LED; wavelength, 635 nm; power, 6 mW; frequency, –; beam area, – Irradiance, –; time, 5 min (total); energy, –; radiant exposure, – The use of low-level laser emitting toothbrush is a safe and effective treatment option for the management of dentine hypersensitivity.…”

Section: Resultsmentioning

confidence: 99%

“…For articles that did report light measurement methods, the most common was using a power meter (22 %; 16/74), or equivalent. Remarkably, only six (6/74; 8 %) employed a method that was able to measure spectral properties such as wavelength [ 39 , 45 , 54 , 67 , 68 , 83 ]. Two articles (3 %; 2/74) failed to report even manufacturers quoted wavelength [ 48 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

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The dark art of light measurement: accurate radiometry for low-level light therapy

et al. 2016

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Lasers and light-emitting diodes are used for a range of biomedical applications with many studies reporting their beneficial effects. However, three main concerns exist regarding much of the low-level light therapy (LLLT) or photobiomodulation literature; (1) incomplete, inaccurate and unverified irradiation parameters, (2) miscalculation of ‘dose,’ and (3) the misuse of appropriate light property terminology. The aim of this systematic review was to assess where, and to what extent, these inadequacies exist and to provide an overview of ‘best practice’ in light measurement methods and importance of correct light measurement. A review of recent relevant literature was performed in PubMed using the terms LLLT and photobiomodulation (March 2014–March 2015) to investigate the contemporary information available in LLLT and photobiomodulation literature in terms of reporting light properties and irradiation parameters. A total of 74 articles formed the basis of this systematic review. Although most articles reported beneficial effects following LLLT, the majority contained no information in terms of how light was measured (73 %) and relied on manufacturer-stated values. For all papers reviewed, missing information for specific light parameters included wavelength (3 %), light source type (8 %), power (41 %), pulse frequency (52 %), beam area (40 %), irradiance (43 %), exposure time (16 %), radiant energy (74 %) and fluence (16 %). Frequent use of incorrect terminology was also observed within the reviewed literature. A poor understanding of photophysics is evident as a significant number of papers neglected to report or misreported important radiometric data. These errors affect repeatability and reliability of studies shared between scientists, manufacturers and clinicians and could degrade efficacy of patient treatments. Researchers need a physicist or appropriately skilled engineer on the team, and manuscript reviewers should reject papers that do not report beam measurement methods and all ten key parameters: wavelength, power, irradiation time, beam area (at the skin or culture surface; this is not necessarily the same size as the aperture), radiant energy, radiant exposure, pulse parameters, number of treatments, interval between treatments and anatomical location. Inclusion of these parameters will improve the information available to compare and contrast study outcomes and improve repeatability, reliability of studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The dark art of light measurement: accurate radiometry for low-level light therapy

et al. 2016

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Modification in oxidative processes in muscle tissues exposed to laser- and light-emitting diode radiation

2017

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Exposure of living tissues to high-intensity red or near-infrared light can produce the oxidative stress effects both in the target zone and adjacent ones. The protein oxidative modification (POM) products can be used as reliable and early markers of oxidative stress. The contents of modified proteins in the investigated specimens can be evaluated by the 2,4-dinitrophenylhydrazine assay (the DNPH assay). Low-intensity red light is able to decrease the activity of oxidative processes and the DNPH assay data about the POM products in the biological tissues could show both an oxidative stress level and an efficiency of physical agent protection against the oxidative processes. Two control groups of white rats were irradiated by laser light, the first control group by red light and the second one by near-infrared radiation (NIR).Two experimental groups were consequently treated with laser and red low-level light-emitting diode radiation (LED). One of them was exposed to red laser light + LED and the other to NIR + LED. The fifth group was intact. Each group included ten animals. The effect of laser light was studied by methods of protein oxidative modifications. We measured levels of both induced and spontaneous POM products by the DNPH assay. The dramatic increase in levels of POM products in the control group samples when compared with the intact group data as well as the sharp decrease in the POM products in the experimental groups treated with LED low-level light were statistically significant (p ≤ 0.05). Exposure of skeletal muscles to high-intensity red and near-infrared laser light causes oxidative stress that continues not less than 3 days. The method of measurement of POM product contents by the DNPH assay is a reliable test of an oxidative process rate. Red low-intensity LED radiation can provide rehabilitation of skeletal muscle tissues treated with high-intensity laser light.

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Influence of Low-Intensive Red Light on the Myocardium in Experimental Asphyxia

2018

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We studied the effects of low-intensity broadband red light on electrical activity of the heart and oxidative modification of proteins in the myocardium of rats after asphyxia. It was shown that low-intensity red light reduced the content of oxidatively modified proteins in rat heart after oxidative stress caused by asphyxia. Exposure to low-intensity red light normalized ECG parameters in rats after asphyxia.

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Correction of Aftereffects of Ionizing Radiation by Exposure to Low-Intensity Light

Cited by 3 publications

References 2 publications

The dark art of light measurement: accurate radiometry for low-level light therapy

The dark art of light measurement: accurate radiometry for low-level light therapy

Modification in oxidative processes in muscle tissues exposed to laser- and light-emitting diode radiation

Influence of Low-Intensive Red Light on the Myocardium in Experimental Asphyxia

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