Correction: Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice

Li, Zhenzu; Zhang, Tingting; Lin, Zhuchun; Hou, Chunying; Zhang, Jian; Men, Yuqin; Li, Huashun; Gao, Jiangang

doi:10.1371/journal.pone.0182505

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“…Lgl1 systemic knockout mice are lethal by birth and show severe brain malformations with hydrocephalus . Our previous studies have showed that the absence of Lgl1 causes abnormal development of the cerebellum and olfactory bulb . In our recent study, deletion of Lgl1 resulted in cortical heterotopia .…”

Section: Introductionmentioning

confidence: 74%

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Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice

Zhang

Hou

Zhang

et al. 2019

Genes Brain and Behavior

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Cellular polarity is crucial for brain development and morphogenesis. Lethal giant larvae 1 (Lgl1) plays a crucial role in the establishment of cell polarity from Drosophila to mammalian cells. Previous studies have found the importance of Lgl1 in the development of cerebellar, olfactory bulb, and cerebral cortex. However, the role of Lgl1 in hippocampal development during the embryonic stage and function in adult mice is still unknown. In our study, we created Lgl1‐deficient hippocampus mice by using Emx1‐Cre mice. Histological analysis showed that the Emx1‐Lgl1−/− mice exhibited reduced size of the hippocampus with severe malformations of hippocampal cytoarchitecture. These defects mainly originated from the disrupted hippocampal neuroepithelium, including increased cell proliferation, abnormal interkinetic nuclear migration, reduced differentiation, increased apoptosis, gradual disruption of adherens junctions, and abnormal neuronal migration. The radial glial scaffold was disorganized in the Lgl1‐deficient hippocampus. Thus, Lgl1 plays a distinct role in hippocampal neurogenesis. In addition, the Emx1‐Lgl1−/− mice displayed impaired behavioral performance in the Morris water maze and fear conditioning test.

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Section: Introductionmentioning

confidence: 74%

“…24 Our previous studies have showed that the absence of Lgl1 causes abnormal development of the cerebellum and olfactory bulb. 25,26 In our recent study, deletion of Lgl1 resulted in cortical heterotopia. 27 The above evidence suggest Lgl1 plays a key role in the central nervous system.…”

Section: Introductionmentioning

confidence: 92%