Correction: Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis

Mahanty, Sarmistha; Dakappa, Shruthi Shirur; Shariff, Rezwan; Patel, Saloni; Swamy, Mruthyunjaya Mathapathi; Majumdar, A.K.; Setty, Subba Rao Gangi

doi:10.1038/s41419-019-1981-7

Cited by 2 publications

(1 citation statement)

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“…[62] These phenomena are caused by decreased calcium levels in the keratinocytes, suggesting that calcium concentration determines keratin differentiation. [61,63] Therefore, we confirmed the change of KRTs in IMQ-induced psoriatic skin. IMQ-induced skin increased keratin levels of KRT14 and KRT17 associated with abnormal differentiation, while decreasing KRT1.…”

Section: Cap Patch Alleviates Lesions With Psoriatic Characteristicssupporting

confidence: 72%

Portable Cold Atmospheric Plasma Patch‐Mediated Skin Anti‐Inflammatory Therapy

Kim

Lee

et al. 2022

Advanced Science

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Although plasma is a promising technology in various fields, its clinical application is restricted by several limitations. A cold atmospheric plasma (CAP) patch is fabricated to help overcome hurdles, especially when treating skin diseases. This patch has surface dielectric barrier discharge, which generates reactive oxygen species (ROS) and reactive nitrogen species (RNS) on a flexible polymer film surface on which the embedded electrode induces a locally strong electric field. The effect of the CAP patch on psoriasis is also evaluated. The distinct characteristics of psoriasis between the lesion and non-lesion area allow the CAP patch to be suitable for only lesion area for its treatment. The CAP patch induces the opening of calcium channels in keratinocytes, thereby restoring abnormal keratinocyte differentiation and the collapse of the tight junction; thus, alleviating psoriatic symptoms. In addition, the favorable effect is due to the induction of ROS/RNS by the CAP patch, not the electric field generated during plasma generation. The findings indicate that the proposed portable CAP patch can help treat inflammatory skin disorders, especially psoriasis. As this can be used easily as a combination therapy with existing drugs, it may help reduce side effects caused by existing drugs.

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Section: Cap Patch Alleviates Lesions With Psoriatic Characteristicssupporting

confidence: 72%

Portable Cold Atmospheric Plasma Patch‐Mediated Skin Anti‐Inflammatory Therapy

Kim

Lee

et al. 2022

Advanced Science

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Insights into Autophagic Machinery and Lysosomal Function in Cells Involved in the Psoriatic Immune-Mediated Inflammatory Cascade

Kuczyńska,

Moskot,

Gabig-Cimińska

2024

Archivum Immunologiae Et Therapiae Experimentalis

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Impaired autophagy, due to the dysfunction of lysosomal organelles, contributes to maladaptive responses by pathways central to the immune system. Deciphering the immune–inflammatory ecosystem is essential, but remains a major challenge in terms of understanding the mechanisms responsible for autoimmune diseases. Accumulating evidence implicates a role that is played by a dysfunctional autophagy–lysosomal pathway (ALP) and an immune niche in psoriasis (Ps), one of the most common chronic skin diseases, characterized by the co-existence of autoimmune and autoinflammatory responses. The dysregulated autophagy associated with the defective lysosomal system is only one aspect of Ps pathogenesis. It probably cannot fully explain the pathomechanism involved in Ps, but it is likely important and should be seriously considered in Ps research. This review provides a recent update on discoveries in the field. Also, it sheds light on how the dysregulation of intracellular pathways, coming from modulated autophagy and endolysosomal trafficking, characteristic of key players of the disease, i.e., skin-resident cells, as well as circulating immune cells, may be responsible for immune impairment and the development of Ps.

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Correction: Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis

Cited by 2 publications

References 0 publications

Portable Cold Atmospheric Plasma Patch‐Mediated Skin Anti‐Inflammatory Therapy

Portable Cold Atmospheric Plasma Patch‐Mediated Skin Anti‐Inflammatory Therapy

Insights into Autophagic Machinery and Lysosomal Function in Cells Involved in the Psoriatic Immune-Mediated Inflammatory Cascade

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