Portable Cold Atmospheric Plasma Patch‐Mediated Skin Anti‐Inflammatory Therapy

Abstract

Although plasma is a promising technology in various fields, its clinical application is restricted by several limitations. A cold atmospheric plasma (CAP) patch is fabricated to help overcome hurdles, especially when treating skin diseases. This patch has surface dielectric barrier discharge, which generates reactive oxygen species (ROS) and reactive nitrogen species (RNS) on a flexible polymer film surface on which the embedded electrode induces a locally strong electric field. The effect of the CAP patch on psoriasis is also evaluated. The distinct characteristics of psoriasis between the lesion and non-lesion area allow the CAP patch to be suitable for only lesion area for its treatment. The CAP patch induces the opening of calcium channels in keratinocytes, thereby restoring abnormal keratinocyte differentiation and the collapse of the tight junction; thus, alleviating psoriatic symptoms. In addition, the favorable effect is due to the induction of ROS/RNS by the CAP patch, not the electric field generated during plasma generation. The findings indicate that the proposed portable CAP patch can help treat inflammatory skin disorders, especially psoriasis. As this can be used easily as a combination therapy with existing drugs, it may help reduce side effects caused by existing drugs.

A Prospective Randomized Controlled Pilot Study to Assess the Response and Tolerability of Cold Atmospheric Plasma for Rosacea

“…Furthermore, different studies have suggested CAP for the treatment of cancer [37,38]. Atopic dermatitis, psoriasis, and herpes zoster, among others, are further skin diseases in which CAP has been successfully applied [23,[39][40][41][42]. Recently, Karrer et al [43] used a jet plasma device in a prospective, randomized, controlled, split-face trial to assess its safety and efficacy in the treatment of acne vulgaris.…”

Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer

“…CP has also shown efficacy against psoriasis, an inflammatory skin condition with abnormal keratinocyte activity that exhibit aberrant MAPK, PI3K/Akt, STAT3 and NFκB pathway [270]. Although the molecular pathway responses to CP in psoriasis are not well characterised, CP inhibits STAT3 activation and significantly remedy inflammatory and epidermal hypertrophic pathologies in a psoriasis mouse model [271,272].…”

Pencil-on-paper flexible DBD plasma for surface disinfection

“…15 To counteract such challenges, flexible DBD plasma has recently been developed to conform to intricate structures and irregular surfaces, enabling effective plasma treatment in complex environments. The flexibility of the plasma could provide incomparable advantages compared to rigid structure plasma sources and can be applied in various applications such as wound healing, 16 food processing, 17,18 and surface disinfection. 19 The production cost of flexible DBD plasma devices is affected by the material choice of the dielectric and conductive electrodes.…”

“…Conventional methods for electrode deposition of thin film flexible plasma are ink-jet printing and screen-printing of conductive inks such as copper or silver on the dielectric surface. 16,30 However, the conductive inks require a post-deposition thermal sintering process at high temperatures, thus creating mild deformation on the paper structure. 31 Recently, Mazzeo et al used metalized paper for DBD plasma, with the paper layer acting as the dielectric barrier and the metal layer engraved into an electrode structure.…”