Correction: Inflammation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: Importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio

Curbelo, José; Luquero-Bueno, Sergio; Galván-Román, José María; Ortega-Gómez, Mara; Rajas, Olga; Fernández-Jiménez, Guillermo; Vega-Piris, Lorena; Rodríguez-Salvanés, Francisco; Arnalich, Belén; Díaz, Ana García; Costa, Ramón; Fuente, Hortensia de la; Lancho, A.; Suárez, Carmen; Ancochea, Julio; Aspa, Javier

doi:10.1371/journal.pone.0212915

Cited by 9 publications

(9 citation statements)

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“…The NLR, a well-known marker of systemic inflammation and infection, has been studied as a predictor of outcomes in many infections, including pneumonia. In these studies, it was found that lymphopenia was detected in most of the infected patients when laboratory tests were evaluated and that infection-related biomarker levels elevated and as a result, NLR and PLR increased [10,[17][18][19]. Similar to the present study, these rates were higher in the group of patients who were admitted to the ICU and those who died compared to patients with COVID-19 who were hospitalized in the service [20,21].…”

Section: Univariate and Multivariate Logistic Regression Analyses To Determine The Independent Predictors Of Mortalitysupporting

confidence: 83%

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Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for mortality in patients infected with SARS-CoV-2

Bozan¹,

Çekmen

Atiş

et al. 2021

Ukr. J. Nephrol. and Dial.

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The COVID-19 pandemic, which originated in China and spread all over the world, continues to be a significant public health crisis. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are valuable parameters that can be evaluated in routine blood tests and provide information about the inflammation in many diseases. This study aimed to evaluate the effect of NLR and PLR on mortality. Methods. Our cross-sectional cohort study included patients who were hospitalized due to COVID-19 with positive polymerase chain reaction test results and patients whose test results were negative at the time of the first admission to the hospital, but whose computed tomography imaging was suspicious for COVID-19 and test results were found to be positive in repeated tests during their hospitalization. Prognosis of the hospitalization outcomes was investigated and discharge, hospital admission, intensive care unit (ICU) admission, and mortality data during the 30 days were recorded and the relationship between these parameters was evaluated. Results. The mean age of the patients was 57.5 ± 16.7 years. Cough was the most common symptom and was present in over half of patients. Almost one-third of patients (27.1%) had at least three symptoms at presentation. Both increased levels of NLR and PLR were observed to significantly predict the mortality of patients with COVID-19 (p<0.001, p=0.001, respectively). Sensitivity and specificity were 65.2% and 80.4% for NLR (AUC: 0.767, cut-off>5.49) and 43.5% and 81.9% for PLR, respectively (AUC: 0.622, cut-off>228.13). Conclusions. The present study has concluded that NLR and PLR are effective mortality predictors in patients infected with SARS-CoV-2.

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Section: Univariate and Multivariate Logistic Regression Analyses To Determine The Independent Predictors Of Mortalitysupporting

confidence: 83%

“…Receiver operating characteristic (ROC) curve analysis was used to examine the relationship between mortality and PLR and NLR. The method proposed by Delong et al was used for calculating the area under ROC curves (AUCs) [10].…”

mentioning

confidence: 99%

Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for mortality in patients infected with SARS-CoV-2

Bozan¹,

Çekmen

Atiş

et al. 2021

Ukr. J. Nephrol. and Dial.

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“…However, the mechanism leading to lymphopenia during COVID-19 still needs to be elucidated. It may be due to the direct contribution of the virus or redistribution of WBC via chemotaxis or apoptosis [ 26 , 27 , 28 ]. Nevertheless, the reduction of IFN-γ is likely due to lymphopenia both in maternal and, subsequently, cord blood.…”

Section: Discussionmentioning

confidence: 99%

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

et al. 2023

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COVID-19 is characterized by the immune system’s overreaction resulting in a ‘cytokine storm’, consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers.

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“…NLR increases rapidly after acute physiological stress, often within 6 h and with a good outcome, and may consequently be useful in classifying patients with severe systemic diseases versus patients with milder diseases [ 77 ]. NLR usually begins to decline within a few days, and failure to improve over time correlates with a poor prognosis [ 78 ]. A normal NLR is about 1–3, and values increase in proportion to the degree of physiological stress, especially in septic shock.…”

Section: The Best Biomarkers In Intensive and Perioperative Carementioning

confidence: 99%

Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence

Hernández

Rueda

2023

JPM

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A biomarker is a molecule that can be measured in a biological sample in an objective, systematic, and precise way, whose levels indicate whether a process is normal or pathological. Knowing the most important biomarkers and their characteristics is the key to precision medicine in intensive and perioperative care. Biomarkers can be used to diagnose, in assessment of disease severity, to stratify risk, to predict and guide clinical decisions, and to guide treatments and response to them. In this review, we will analyze what characteristics a biomarker should have and how to ensure its usefulness, and we will review the biomarkers that in our opinion can make their knowledge more useful to the reader in their clinical practice, with a future perspective. These biomarkers, in our opinion, are lactate, C-Reactive Protein, Troponins T and I, Brain Natriuretic Peptides, Procalcitonin, MR-ProAdrenomedullin and BioAdrenomedullin, Neutrophil/lymphocyte ratio and lymphopenia, Proenkephalin, NefroCheck, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin 6, Urokinase-type soluble plasminogen activator receptor (suPAR), Presepsin, Pancreatic Stone Protein (PSP), and Dipeptidyl peptidase 3 (DPP3). Finally, we propose an approach to the perioperative evaluation of high-risk patients and critically ill patients in the Intensive Care Unit (ICU) based on biomarkers.

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Correction: Inflammation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: Importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio

Cited by 9 publications

References 1 publication

Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for mortality in patients infected with SARS-CoV-2

Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for mortality in patients infected with SARS-CoV-2

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence

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