Correction: Impact of intravascular hemolysis in malaria on liver dysfunction: Involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration

Dey, Sumanta; Goyal, Manish; Pal, Chiranjib; Alam, Athar; Iqbal, Mohammad; Kumar, Rahul; Sarkar, Souvik; Bandyopadhyay, Uday

doi:10.1074/jbc.aac119.012033

Cited by 26 publications

(33 citation statements)

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“…4 Intracellular heme concentrations are tightly controlled by its enzymatic degradation via heme oxygenases (HO), 5 yielding the first-order degradation products biliverdin, ferrous iron, and carbon monoxide (CO). 6,7 The induction of HO-1 reflects a hallmark of the cellular response to oxidative stress and confers tissue protection during infection and inflammation. 8,9 Bilirubin, generated from biliverdin by biliverdin reductases, contributes to tissue integrity via its anti-oxidative properties.…”

Section: Impact Of Higher-order Heme Degradation Products On Hepatic mentioning

confidence: 99%

Impact of higher-order heme degradation products on hepatic function and hemodynamics

Seidel

Claudel

Schleser

et al. 2017

Journal of Hepatology

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Degradation of the blood pigment heme yields the bile pigment bilirubin and the oxidation products Z-BOX A and Z-BOX B. Serum concentrations of these bioactive molecules increase in jaundice and can impair liver function and integrity. Amounts of Z-BOX A and Z-BOX B that are observed during liver failure in humans have profound effects on hepatic function when added to cultured liver cells or infused into healthy rats.

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Section: Impact Of Higher-order Heme Degradation Products On Hepatic mentioning

confidence: 99%

Impact of higher-order heme degradation products on hepatic function and hemodynamics

Seidel

Claudel

Schleser

et al. 2017

Journal of Hepatology

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“…Besides using the EO from Allium sativum and Allium cepa externally as a repellent and larvicide in vector control, the idea of using it as a therapeutic compound in Malaria is also brought about in this study by assessing their Antihemolytic activity. The reports of Dey et al, [20] justify the acceleration of intravascular hemolysis during malarial infection eventually degrading the total RBC hemogobin and damaging the vital organs. The outcome from the Antihemolytic activity observed in the erythrocytes with H2O2 induced oxidative stress (Table : 3 & Figure : 3) suggests the prevention of erythrocyte lysis in a concentration dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Chemical Profiling, Larvicidal Activity and Antihemolytic Property of Allium sativum L. and Allium cepa L. Essential Oil

Durgadevi¹,

Sumathi²

2021

JUSST

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Essential oils are plant derived concentrates of the secondary metabolites responsible for the aromatic flavor attributing to its various medicinal properties. Fresh Allium sativum (A. sativum) and Allium cepa (A. cepa) were subjected to steam distillation for isolation of essential oil characterized by performing Gas Chromatography – Mass Spectroscopy (GC-MS). Chromatogram of the essential oil depicted the presence diallyl sulfide (5.35%), 2-(2’-carbamoylphenoxy)-butanoic acid (2.64%), 2-ethyl-5-methylthiophene (0.42%), diallyl disulphide (18.76%), 3-(2-thia-4-pentenyl)-1-thia-cyclohex-5-ene (1.09%) and dimethyl tetrasulphide (0.15%), 2,4-dimethylpyrido[2,3-d]pyrimidin-5-one (47.91%), 2,4-Thiazolidinedione (0.01%), 5-chloro-2-hydroxy-1,3-dinitrobenzene (5.93%), 6-Methoxy-1-methyl-3,4-dihydroisoquinoline (47.91%) in A. sativum and A.cepa respectively. Larvicidal activity against third instar larvae of Anopheles stephensi (A. Stephensi) was assessed by following the standard protocol of World Health Organization. The 50% lethality (LC50) of A. stephensi larvae was observed at 265.96 ± 1.88 ppm and 357.14 ± 2.36 ppm of A. sativum and A. cepa essential oil correspondingly. The mortality rate of the larvae was both time and dose dependent. Besides, the in vitro antihemolytic activity of the essential oil was also assessed using Sheep erythrocytes. The erythrocyte lysis was inhibited by the essential oils of both A. sativum and A. cepa in a concentration dependent manner with an IC50 of 427.35 ± 1.23 μl and 549.45 ± 1.38 μl respectively. On a comparative assessment between the essential oils of A. sativum and A. cepa, the former exhibited better larvicidal activity against the disease-causing vector, A. stephensi. Still, both could serve as potent insecticidal agents after further identification of the responsible chemical compound and its mode of action.

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“…It is widely described in literature that human malaria is characterized by intense hepatotoxicity and liver dysfunction, and although hepatic dysfunction in malaria is not fully understood, oxidative stress is often related to this condition [17]. As demonstrated in both human patients and animals models, liver damage during Plasmodium infection occurs as a result of free heme accumulation that triggers severe oxidative stress and stimulates proinflammatory response by tumor necrosis factor (TNF-α) release [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced by Plasmodium berghei ANKA Infection

Kauffmann

Penha

Braga

et al. 2021

BioMed Research International

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Malaria is a life-threatening disease caused by Plasmodium and represents one of the main public health problems in the world. Among alterations associated with the disease, we highlight the hepatic impairment resulting from the generation of oxidative stress. Studies demonstrate that liver injuries caused by Plasmodium infection are associated with unbalance of the antioxidant system in hepatocytes, although little is known about the role of antioxidant molecules such as glutathione and vitamin C in the evolution of the disease and in the liver injury. To evaluate disease complications, murine models emerge as a valuable tool due to their similarities between the infectious species for human and mice. Herein, the aim of this study is to evaluate the effect of antioxidants glutathione and vitamin C on the evolution of murine malaria and in the liver damage caused by Plasmodium berghei ANKA infection. Mice were inoculated with parasitized erythrocytes and treated with glutathione and vitamin C, separately, both at 8 mg/kg during 7 consecutive days. Our data showed that during Plasmodium infection, treatment with glutathione promoted significant decrease in the survival of infected mice, accelerating the disease severity. However, treatment with vitamin C promoted an improvement in the clinical outcomes and prolonged the survival curve of infected animals. We also showed that glutathione promoted increase in the parasitemia rate of Plasmodium-infected animals, although treatment with vitamin C has induced significant decrease in parasitemia rates. Furthermore, histological analysis and enzyme biochemical measurement showed that treatment with glutathione exacerbates liver damage while treatment with vitamin C mitigates the hepatic injury induced by the infection. In summary, the current study provided evidences that antioxidant molecules could differently modulate the outcome of malaria disease; while glutathione aggravated the disease outcome and liver injury, the treatment with vitamin C protects the liver from damage and the evolution of the condition.

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Correction: Impact of intravascular hemolysis in malaria on liver dysfunction: Involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration

Cited by 26 publications

References 0 publications

Impact of higher-order heme degradation products on hepatic function and hemodynamics

Impact of higher-order heme degradation products on hepatic function and hemodynamics

Chemical Profiling, Larvicidal Activity and Antihemolytic Property of Allium sativum L. and Allium cepa L. Essential Oil

Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced by Plasmodium berghei ANKA Infection

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