Correction for Cekanaviciute et al., Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

doi:10.1073/pnas.1716911114

Cited by 10 publications

(5 citation statements)

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“…Trillions of gut microbiota mediate multiple functions for the host, and in particular help shape the immune system (182)(183)(184). In MS, studies have shown that transfer of fecal microbiota transplant (FMT) from patients with MS to recipient mice can induce experimental autoimmune encephalomyelitis (EAE), MS-like disease in mice (185)(186)(187), suggesting that gut microbes are a vital aspect of autoimmune induction. Likewise, cancer phenotypes can be transferred via FMT (188).…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Melamed

Lee

2020

Front. Immunol.

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Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS.

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Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Melamed

Lee

2020

Front. Immunol.

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“…В исследовании Cekanaviciute E. с cоавт. (2017) [23] одним из преимущественных родов в составе микробиоты пациентов с РС был Acinetobacter. Мы не определяли эти бактерии методом ПЦР, а при бактериологическом исследовании Acinetobacter baumannii были выделены лишь у одного пациента, причем в сочетании с E. cloacae и C. perfringens.…”

Section: Discussionunclassified

“…Cekanaviciute E. и соавт. (2017) [23] получили сходный эффект in vitro, когда к мононуклеарным клеткам крови доноров добавляли экстракты из образцов стула, содержавших А. muciniphila, количество Th1, продуцирующих IFNγ, было больше, чем при добавлении экстрактов, не содержавших А. muciniphila.…”

Section: Discussionunclassified

Intestinal microbiota composition and peripheral blood Th cell subsets in patients with multiple sclerosis

Абдурасулова

Tarasova

Кудрявцев

et al. 2019

Russian Journal of Infection and Immunity

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At present, the role of intestinal microbiota in diverse diseases of the central nervous system, including of multiple sclerosis (MS) has been extensively investigated. Self-reactive CD4+ Th1 and Th17 cells specific to myelin-derived antigens play a key role in the MS pathogenesis. Taking into consideration pathogenetic features related to MS development, we examined a relation between intestinal microbiocenosis and abundance of various peripheral blood helper T (Th) cell subsets in MS patients. Objective of the study: to assess prevalence of individual members of the intestinal microbiota in MS patients and analyze a relation with peripheral blood Th cell subsets. Prevalence of symbiotic and opportunistic microbial species was estimated by bacteriological method and real time PCR in 112 MS patients (72 females, 40 males) of varying severity and duration. Th cell subsets (Th1, Th2, Th17, Th1/Th17, Th17/Th22, DP Th17) were analyzed by using multi-color flow cytometry based on Th cell subset-specific surface expression of chemokine receptors. A relationship between individual intestinal microbiota species and severity, duration and rate of MS progression, as well as with the phenotype of immune cells was assessed. It was found that the most significant correlation between percentage of peripheral blood Th cell subsets was observed with prevalence of Lactobacillus spp., Enterococcus spp. and Enterobacter spp. Moreover, prevalence of Enterococcus spp. Th cell composition influenced synergistically or antagonistically together with Enterobacter spp. or Lactobacillus spp., respectively. It is suggested that direct and indirect impact of intestinal microbiota composition on human immune system might contribute to developing novel strategies for treating MS.

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“…Of note, as mediators of intestinal homeostasis contributing to peripheral immune balance, SCFAs are particularly important targets in restoring MS gut-brain axis perturbation [50]. For example, MS intestinal microbiota composition witnesses a significant reduction of SCFAs-producing bacteria compared to healthy controls [100], which is sufficient to deliver an EAE susceptibility [101,102], accordingly, high-fiber diet or direct SCFAs supplementation, succeeds in dampening disease activity [54].…”

Section: Scfas and Cd4 + T Lymphocyte Subtype Prevalencementioning

confidence: 99%

Fatty acids role in multiple sclerosis as “metabokines”

Bai

Hao

et al. 2022

J Neuroinflammation

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Multiple sclerosis (MS), as an autoimmune neurological disease with both genetic and environmental contribution, still lacks effective treatment options among progressive patients, highlighting the need to re-evaluate disease innate properties in search for novel therapeutic targets. Fatty acids (FA) and MS bear an interesting intimate connection. FA and FA metabolism are highly associated with autoimmunity, as the diet-derived circulatory and tissue-resident FAs level and composition can modulate immune cells polarization, differentiation and function, suggesting their broad regulatory role as “metabokines”. In addition, FAs are indeed protective factors for blood–brain barrier integrity, crucial contributors of central nervous system (CNS) chronic inflammation and progressive degeneration, as well as important materials for remyelination. The remaining area of ambiguity requires further exploration into this arena to validate the existed phenomenon, develop novel therapies, and confirm the safety and efficacy of therapeutic intervention targeting FA metabolism.

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Correction for Cekanaviciute et al., Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Cited by 10 publications

References 0 publications

Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Intestinal microbiota composition and peripheral blood Th cell subsets in patients with multiple sclerosis

Fatty acids role in multiple sclerosis as “metabokines”

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