Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka, Essaïd Ait; Vatsa, Parul; Sanchez, Lisa; Gaveau-Vaillant, Nathalie; Jacquard, Cédric; Meier‐Kolthoff, Jan P.; Klenk, Hans‐Peter; Clément, C.; Ouhdouch, Yder; Wezel, Gilles P. van

doi:10.1128/mmbr.00044-16

Cited by 101 publications

(114 citation statements)

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“…Second, the intra-phylum variations of the multigene Psp configurations observed in Firmicutes and Actinobacteria may reflect different life styles. Indeed, the phylum Actinobacteria exhibits remarkable biodiversity among its members [56]. Third, comparing Psp configurations across genera may also lead to identification of chromosomal rearrangements.…”

Section: Discussionmentioning

confidence: 99%

Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme

Manganelli¹,

Gennaro²

2017

Trends in Microbiology

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During envelope stress, critical inner-membrane functions are preserved by the phage-shockprotein (Psp) system, a stress response that emerged from work with Escherichia coli and other Gram-negative bacteria. Reciprocal regulatory interactions and multiple effector functions are well documented in these organisms. Searches for the Psp system across phyla reveals conservation of only one protein, PspA. However, examination of Firmicutes and Actinobacteria reveals that PspA orthologs associate with non-orthologous regulatory and effector proteins retaining functions similar to those in Gram-negative counterparts. Conservation across phyla emphasizes the longstanding importance of the Psp system in prokaryotes, while inter-and intra-phyla variations within the system indicate adaptation to different cell envelope structures, bacterial lifestyles, and/or bacterial morphogenetic strategies.

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Section: Discussionmentioning

confidence: 99%

Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme

Manganelli¹,

Gennaro²

2017

Trends in Microbiology

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“…[9][10][11][12][13][14][15][16] NPs continue to be important sources of new and novel chemical scaffolds for drug discovery, 17,18 and actinomycetes, particularly Streptomyces species, continue to be the most productive sources. 4,19,20 To access the enormous untapped cryptic SM coding capacity of actinomycetes, it is critical to develop robust approaches to activate gene cluster expression. Many approaches, including isolation of mutants altered in transcription or translation, genetic manipulation of positive and negative regulation, heterologous expression in specialized hosts and others, have been described.…”

Section: Introductionmentioning

confidence: 99%

Molecular beacons to identify gifted microbes for genome mining

Baltz¹

2017

J Antibiot

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Microbial genome mining is a promising technology that is revitalizing natural product discovery. It is now well documented that many bacteria with large genomes, particularly actinomycetes, encode many more secondary metabolites (SMs) than was previously known from their expressed secondary metabolomes. There are effective bioinformatics tools for counting the numbers and nature of SMs, and determining the total coding capacity from finished microbial genomes. However, these methods do not translate well to draft genomes, particularly for large SM gene clusters that contain nonribosomal peptide synthetase (NRPS) or type I polyketide synthase (PKS-I) mega-genes which are prone to fragmentation and misassembly. Small molecular beacons are required to assess the numbers and variety of NRPS, PKS-I and mixed NRPS/PKS-I pathways. In this report, I show that concatenated peptidyl carrier protein-thioesterase di-domains and acyl carrier protein-thioesterase di-domains can be used as multi-probes to survey finished or draft genomes to estimate the numbers of NRPS, PKS-I and mixed NRPS/PKS-I gene clusters to identify gifted actinomycetes.

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“…The phylum Actinobacteria is one of the major phyla of the domain Bacteria and contains Gram-positive filamentous bacteria with a high G+C DNA content and different morphological, physiological and metabolic characteristics [1][2][3]. Most bacteria belonging to this phylum are free-living micro-organisms that are ubiquitously found in both aquatic and terrestrial ecosystems and include the following: (i) several pathogens, such as species of Corynebacterium, Mycobacterium, Nocardia, Propionibacterium and Tropheryma; (ii) soil inhabitants, such as Micromonospora spp.…”

Section: Introductionmentioning

confidence: 99%

“…; and (iv) gastrointestinal commensals, such as Bifidobacterium spp. [1]. Their diversity ensures one of the main features of this group: versatility in the production of biologically active compounds, including antimicrobial substances [4].…”

Section: Introductionmentioning

confidence: 99%

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Lantibiotics produced by Actinobacteria and their potential applications (a review)

Gomes¹,

Duarte²,

Bastos³

2017

Microbiology

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The phylum Actinobacteria, which comprises a great variety of Gram-positive bacteria with a high G+C content in their genomes, is known for its large production of bioactive compounds, including those with antimicrobial activity. Among the antimicrobials, bacteriocins, ribosomally synthesized peptides, represent an important arsenal of potential new drugs to face the increasing prevalence of resistance to antibiotics among microbial pathogens. The actinobacterial bacteriocins form a heterogeneous group of substances that is difficult to adapt to most proposed classification schemes. However, recent updates have accommodated efficiently the diversity of bacteriocins produced by this phylum. Among the bacteriocins, the lantibiotics represent a source of new antimicrobials to control infections caused mainly by Gram-positive bacteria and with a low propensity for resistance development. Moreover, some of these compounds have additional biological properties, exhibiting activity against viruses and tumour cells and having also potential to be used in blood pressure or inflammation control and in pain relief. Thus, lantibiotics already described in Actinobacteria exhibit potential practical applications in medical settings, food industry and agriculture, with examples at different stages of pre-clinical and clinical trials.

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Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria

Cited by 101 publications

References 0 publications

Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme

Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme

Molecular beacons to identify gifted microbes for genome mining

Lantibiotics produced by Actinobacteria and their potential applications (a review)

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