2017
DOI: 10.1099/mic.0.000397
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Lantibiotics produced by Actinobacteria and their potential applications (a review)

Abstract: The phylum Actinobacteria, which comprises a great variety of Gram-positive bacteria with a high G+C content in their genomes, is known for its large production of bioactive compounds, including those with antimicrobial activity. Among the antimicrobials, bacteriocins, ribosomally synthesized peptides, represent an important arsenal of potential new drugs to face the increasing prevalence of resistance to antibiotics among microbial pathogens. The actinobacterial bacteriocins form a heterogeneous group of subs… Show more

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Cited by 43 publications
(24 citation statements)
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“…Regarding bacteria, we found a negative correlation between the phylum Actinobacteria and saliva lactate concentration. This phylum comprises a large variety of Gram-positive bacteria and is known for its high production of bioactive compounds, including those with antimicrobial activity such as lantibiotics 23 . For instance, Nisin is one of the best known antibiotics for its highly effective bactericidal activity against most lactic acid bacteria 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Regarding bacteria, we found a negative correlation between the phylum Actinobacteria and saliva lactate concentration. This phylum comprises a large variety of Gram-positive bacteria and is known for its high production of bioactive compounds, including those with antimicrobial activity such as lantibiotics 23 . For instance, Nisin is one of the best known antibiotics for its highly effective bactericidal activity against most lactic acid bacteria 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Proteobacteria, Actinobacteria, and Acidobacteria were found to be the predominant bacterial populations in all safflower soil samples, suggesting that there were more important effects arising from these bacteria. As far as Actinobacteria is concerned, this phylum is known to comprise a great variety of Gram‐positive bacteria with a high G+C DNA content, which can produce about two‐thirds of all naturally derived antibiotics in current clinical use, as well as many bioactive compounds, including those with anticancer and antimicrobial activity [31]. These substances would probably transform into plant nutrients due to the persistence of the rhizosphere effect.…”
Section: Discussionmentioning
confidence: 99%
“…Looking for the homologous clusters of roseocin, we identified a gene cluster encoding a natural variant of roseocin in Glycomyces harbinensis (Figure ) (Labeda, Testa, Lechevalier, & Lechevalier, ). A study on such natural variants is important to understand the role of substitutions on bioactivity and for designing semisynthetic derivatives with improved characteristics (Gomes, Duarte, & Freire, ). Overall, roseocin is the first example of a two‐component lantibiotic from a non‐ Firmicute, with a potential to be used as a therapeutic agent.…”
Section: Discussionmentioning
confidence: 99%