Correction for: Aged cells in human skeletal muscle after resistance exercise

Yang, Ching‐Wen; Jin, Ying; Wei, Bing; Ze-yi, Yang; Wu, Jin Fu; Jensen, Jim; Jean, Wei Horng; Huang, Chih‐Yang; Kuo, Chia‐Hua

doi:10.18632/aging.102338

Cited by 1 publication

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“…The key findings of the study are 1) a doubled EPC and decreased p16 INK4a mRNA in human skeletal muscle 1 day after squat exercise; 2) the exercise-induced EPC rejuvenation and attenuated muscle inflammation were enhanced by pre-exercise Rg1 supplementation. No change in p16 INK4a+ cell number is probably associated with low levels of p16 INK4a+ senescent cell number in muscle tissues of men with regular training [3,7]. It is likely that all replicable cells in the muscle tissue express a wide spectrum of p16 INK4a mRNA levels.…”

Section: Aging Discussionmentioning

confidence: 99%

“…Increasing p16 INK4a expression during cellular aging is also an intrinsic mechanism to lower mitotic error of aged stem cells [4]. Since most of cells within the human body are short-AGING lived [5], p16 INK4a+ senescent cells are widely detectable in embryonic [6] and young adult tissues [7][8][9]. Lymphocyte p16 INK4a mRNA increases exponentially with age from 18 to 80 years old [10].…”

Section: Introductionmentioning

confidence: 99%

“…The effect of an acute bout of resistance exercise on p16 INK4a mRNA in skeletal muscle of trained humans has not been previously reported. Based on IHC analysis, resistance exercise seems to suppress p16 INK4a+ cell number surrounding myofibers in skeletal muscle of untrained men [7] and physically inactive women [3]. A significant proportion of p16 INK4a+ cells are colocalized with CD34 + endothelial progenitor cells (EPC) adjacent to myofibers [7].…”

Section: Introductionmentioning

confidence: 99%

“…Based on IHC analysis, resistance exercise seems to suppress p16 INK4a+ cell number surrounding myofibers in skeletal muscle of untrained men [7] and physically inactive women [3]. A significant proportion of p16 INK4a+ cells are colocalized with CD34 + endothelial progenitor cells (EPC) adjacent to myofibers [7]. EPC contributes to cell regeneration of both vascular endothelium [11] and myofibers in damaged muscle tissues [12].…”

Section: Introductionmentioning

confidence: 99%

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Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1

Lee

Jean

et al. 2021

Aging

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Background: Stem cell aging, characterized by elevated p16 INK4a expression, decreases cell repopulating and selfrenewal abilities, which results in elevated inflammation and slow recovery against stress. Methods: Biopsied muscles were analyzed at baseline and 24 h after squat exercise in 12 trained men (22 ± 2 y). Placebo (PLA) and immunostimulant Rg1 (5 mg) were supplemented 1 h before a squat exercise, using a double-blind counterbalanced crossover design. Results: Perceived exertion at the end of resistance exercise session was significantly lowered after Rg1 supplementation. Exercise doubled endothelial progenitor cells (EPC) (p < 0.001) and decreased p16 INK4a mRNA to 50% of baseline (d = 0.865, p < 0.05) in muscle tissues, despite p16 INK4a+ cell and beta-galactosidase + (ß-Gal + ) cell counts being unaltered. Rg1 further lowered p16 INK4a mRNA to 35% of baseline with greater effect size than the PLA level (d = 1.302, p < 0.01) and decreased myeloperoxidase (MPO) mRNA to 39% of baseline (p < 0.05). A strong correlation between MPO and p16 INK4a expression in muscle tissues was observed (r = 0.84, p < 0.001). Conclusion: EPC in skeletal muscle doubled 1 d after an acute bout of resistance exercise. The exercised effects in lowering EPC aging and tissue inflammation were enhanced by immunostimulant Rg1, suggesting the involvement of immune stimulation on EPC rejuvenation.

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Section: Aging Discussionmentioning

confidence: 99%