Correction: Corrigendum: Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

Virós, Amaya; Sánchez-Laorden, Berta; Pedersen, Malin; Furney, Simon J.; Rae, Joel; Hogan, Kate; Ejiama, Sarah; Girotti, María Romina; Cook, Martin; Dhomen, Nathalie; Marais, Richard

doi:10.1038/nature14057

Cited by 1 publication

(2 citation statements)

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“…[1,2] UV radiationc ontained in sunlight is ac omplete carcinogen because it can damage DNA, suppress antitumor immunity,a nd enhancem etastasis of skin cancers. [3,4] One simple and effective wayt oa void the above detrimental effects is the use UV-protective sunscreens. [5][6][7][8] However,t here has been considerable concern with the issue of the productiono fr eactive oxygen species (ROS) through the photodegradation of commercial organic UV filterso rp hotocatalytic semiconductors, such as ZnO and TiO 2 ,w hich could potentially cause oxidative stress to tissues or damage DNA.…”

Section: Introductionmentioning

confidence: 99%

“…Melanoma and non‐melanoma (basal and squamous cell carcinoma) skin cancers have been identified as the most common types of cancer and are considered the most frequent and fastest growing malignant disease . UV radiation contained in sunlight is a complete carcinogen because it can damage DNA, suppress antitumor immunity, and enhance metastasis of skin cancers . One simple and effective way to avoid the above detrimental effects is the use UV‐protective sunscreens .…”

Section: Introductionmentioning

confidence: 99%

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Confinement of Reactive Oxygen Species in an Artificial‐Enzyme‐Based Hollow Structure To Eliminate Adverse Effects of Photocatalysis on UV Filters

Dong

Wang

et al. 2017

Chemistry A European J

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Skin cancers caused by UV irradiation have been a major public health problem. One simple and effective way to avoid the above detrimental effects is the use of UV-protective sunscreens. However, there has been considerable concern with the issue of the production of reactive oxygen species (ROS) through the photodegradation of commercial UV filters. Herein, for the first time, it is reported that the integration of ZnO nanoparticles and CeO nanoparticles into hollow microspheres (ZnO/CeO HMS) could provide broad-spectrum UV protection and scavenge generated ROS under UV irradiation. Benefiting from the cooperative effect of the hollow structure and the antioxidative activity of CeO , ROS generated under UV irradiation could be confined to a limited space and effectively conversion into nontoxic molecules is catalyzed as a consequence of increased collision frequency. Therefore, both primary, direct UV-induced damage and secondary ROS toxicity could be greatly reduced.

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