Correction: Boron-containing delocalised lipophilic cations for the selective targeting of cancer cells

Abstract

Correction for “Boron-containing delocalised lipophilic cations for the selective targeting of cancer cells” by Gianpiero Calabrese et al., Med. Chem. Commun., 2017, 8, 67–72.

Combining magnetic nanoparticles and icosahedral boron clusters in biocompatible inorganic nanohybrids for cancer therapy

“…This, along with its hydrophobicity and electron withdrawing properties through the carbon cluster, Cc, [35][36][37] suggests the possibility of inducing distinct geometrical behaviour in boron rich macromolecules or particles of significance for Boron Neutron Capture Therapy (BNCT), [38][39][40][41][42][43][44] an alternative radiotherapy used for aggressive and infiltrating types of cancer that can not be treated with surgery or standard radio or chemotherapy, and by drug delivery. 45,46 The theoretical advantage of BNCT is that it can selectively destroy tumour cells infiltrating normal tissue with the requirement that sufficient amounts of 10 B and thermal neutrons are properly delivered to the site of the tumour. [38][39][40][41][42][43][44][45][46] Clinical interest in BNCT has focused primarily on high grade gliomas and on recurrent tumours of the head and neck region who have failed conventional therapy.…”

Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane

“…1) are known to accumulate selectively in the mitochondria of cancerous cells. [1][2][3] This is attributed to the elevated mitochondrial membrane potential present in a broad range of cancer cells compared to healthy epithelial cells (ca. 60 mV e.g.…”

“…−163 mV in colon carcinoma cells vs. −104 mV in kidney epithelial cells). 2,4 Very high tumour to normal tissue uptake ratios (ca. 40 : 1) have been obtained in vivo for 1 and 2.…”

“…40 : 1) have been obtained in vivo for 1 and 2. 1,2 The lipophilic nature of these agents, particularly the reported closocarborane containing salts (e.g. 3, Fig.…”

“…2). 2,[9][10][11][12][13][14] In vivo and in vitro biological distribution studies of phosphonium salts incorporating chelated 64 Cu (e.g. 4) have shown good tumour localization and effective imaging of U87MG human glioma xenografts in athymic nude mice.…”