Corpus Luteum Function in Guinea Pigs, Hamsters, Rats, Mice and Rabbits1

Hilliard, Jessamine

doi:10.1093/biolreprod/8.2.203

Cited by 140 publications

(47 citation statements)

References 89 publications

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“…was used on cows and heifers. The site of action of this effect has not been identified.The guineapig, unlike the rat, mouse and rabbit, but like the cow, the ewe and the human, is both a spontaneous ovulator and has a spontaneous luteal phase (Hilliard, 1973). The guineapig is, therefore, an appropriate model for studying factors affecting ovarian function in ruminants and man.…”

mentioning

confidence: 99%

The action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function in the guineapig

Zarkawi

Galbraith

Hutchinson³

1991

Lab Anim

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SummaryThe action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function was investigated in the guineapig. Certain comparisons were made with testosterone, the naturally occurring androgen, administered as the phenylpropionate ester. Two milligrammes trenbolone acetate per kg given subcutaneously on alternate days for 20 days blocked oestrous cyclicity and ovulation in 9 of 10 animals. A similar effect was shown by 2· 2 mg of testosterone phenylpropionate. Treatment of trenbolone acetate-treated animals with exogenous gonadotrophins suggested that the production of follicle-stimulating hormone had been suppressed. Signs of abnormality were seen in the livers of animals receiving 2 mg trenbolone acetate and 2· 2 mg testosterone phenylpropionate. was used on cows and heifers. The site of action of this effect has not been identified.The guineapig, unlike the rat, mouse and rabbit, but like the cow, the ewe and the human, is both a spontaneous ovulator and has a spontaneous luteal phase (Hilliard, 1973). The guineapig is, therefore, an appropriate model for studying factors affecting ovarian function in ruminants and man. The aim of the present study was to investigate the effect of TBA and a natural androgen, testosterone, on oestrous cyclicity and ovarian function in the guineapig, and to identify the site of its inhibitory action. Materials and methods Animals

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mentioning

confidence: 99%

The action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function in the guineapig

Zarkawi

Galbraith

Hutchinson³

1991

Lab Anim

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“…During the estrous cycle, the level of each sexual hormone changes in a complex manner [10][11][12]. Accordingly, all rats must be matched for estrous cycle stage to allow proper comparison of group data.…”

Section: Animalsmentioning

confidence: 99%

Effect of Garcinia cambogia Administration on Female Reproductive Organs in Rats

Kiyose¹,

Kubo²,

Saito³

2006

J. Clin. Biochem. Nutr.

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Summary We investigated the effect of administering Garcinia cambogia (GA), which contains (−)-hydroxycitric acid ((−)-HCA), to female rats, focusing especially on changes in sexual hormones and its safety in terms of histopathological changes. A diet containing a high level of (−)-HCA (154 mmol / kg diet) was given to seven-week-old female rats with matched estrous cycles for two or four weeks. There were no significant differences in any of the serum hormones tested (follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone) between the control group and the GA group during the observation period. Also, there were no abnormal morphological findings in the follicle and corpus luteum, nor were there any significant differences in the ovarian 4,4-dimethyl-5α-cholesta 8,14,24-triene-3β-ol (follicular fluid meiosis-activating sterol; FF-MAS) and 4,4-dimethyl-5α-cholesta-8,24-diene-3β-ol (testis meiosis-activating sterol; T-MAS) concentrations between the control and the GA groups. On the other hand, the final body weight of the GA group was statistically lower than that of the control group. The weight of abdominal fat in the GA group was markedly lower than that in the control group even after two weeks of feeding. Therefore, although we had confirmed in our previous study that GA had a marked effect on sexual maturation in male rats, no such deleterious influence was observed in the female rats.

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“…Since several reviews of the corpus luteum (CL) including its cytology, biochemistry, and comparative aspects in addition to its endocrine regulation are available (19)(20)(21)(22)(23), only the general features of luteal maintenance and regression will be discussed here.…”

Section: Endocrine Regulation Of Corpus Luteum Functionmentioning

confidence: 99%

Basic mechanisms of ovarian endocrine function

Schomberg¹

1978

Environ Health Perspect

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This review outlines the current understanding of ovarian endocrine development and regulation with both physiological and biochemical background to provide a framework applicable to problems concerning environmental agents and ovarian endocrine function. Two approaches are used. First, the endocrine regulation of foUicle development and corpus luteum function is considered in the classical sense, i.e., viewing these structures as gonadotropin-responsive units undergoing a programmed sequence of development and differentiation. Secondly, a relatively new area of ovarian physiology concerned with intra-ovarian regulation is explored, since this area holds potential for exploration of the direct effects of toxicological or environmental agents upon gonadal endocrine cells. Follicle DevelopmentGonadotropin-Independent and Dependent StagesThe stages of follicular maturation have been classified in a variety of ways by several different investigators, depending upon the degree of detail necessary (1, 2). For purposes of this discussion, distinction need only be made between the following: (1) the primordial follicle stage, characterized by an immature ovum surrounded by a single layer of flattened or disc-shaped granulosa cells; (2) the primary follicle stage, characterized by a transition in granulosa cell morphology to the cuboidal form followed by an increase in the number of granulosa cell layers (In the rat, oocyte growth is complete by the four-layer granulosa cell stage); and (3) Follicle development in most species, with the notable exception of the human (3), is thought to be independent of gonadotropic support up to the

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Corpus Luteum Function in Guinea Pigs, Hamsters, Rats, Mice and Rabbits1

Cited by 140 publications

References 89 publications

The action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function in the guineapig

The action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function in the guineapig

Effect of Garcinia cambogia Administration on Female Reproductive Organs in Rats

Basic mechanisms of ovarian endocrine function

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