Coronavirus Infection in Children

Зверева, Н. Н.; Сайфуллин, М. А.; Rtishchev, A.Yu.; Шамшева, О. В.; Pshenichnaya, N.Yu.

doi:10.24110/0031-403x-2020-99-2-270-278

Cited by 11 publications

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“…У детей с SARS-CoV-1 в возрасте старше 12 лет течение КВИ схоже с взрослыми и сопровождается развитием вирусной пневмонии у части больных на 2-й неделе заболевания, причем клинические проявления сопровождаются выраженной интоксикацией, анорексией и рентгенологическими изменениями, характерными для полисегментарной пневмонии без одышки и выраженного снижения сатурации кислорода. Дети с тяжелыми проявлениями пневмонии требовали перевода в отделение реанимации и интенсивной терапии (ОРИТ), организации кислородной поддержки и применения кортикостероидов [13,14].…”

Section: о б з о р ы л и т е р а т у р ы || L I T E R a T U R E R E V I E W Sunclassified

Coronavirus infection COVID-19. Scientific challenges and possible ways to treat and prevent the disease

Румянцев

2020

Ross. ž. det. gematol. onkol.

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The COVID-19 pandemic has exposed pain points of decentralized healthcare systems in the global world and a failure in scientific systems analysis of old and new infections. Eighteen years ago severe acute respiratory syndrome (SARS) was underestimated and etiopathogenetic research conducted around the world was not used to develop effective treatments and prevention of the disease. Moreover, the anti-epidemic tactics in the recommendations of the World Health Organization and national health systems in the fight against the pandemic were inconsistent and relied on the historical experience of the influenza pandemic and other epidemics of respiratory infections with an emphasis on the study of the biology of the pathogen and the adaptation of society to establish biological and social balance with it.The study of the SARS-CoV-2 virus (severe acute respiratory syndrome-related coronavirus 2) from the point of view of its origin, genome, mutated strains, damaging factors in cell culture in vitro and autopsies in experimental animals and humans in foci of infection in no way answers the question of the reasons for the various responses of the host, including asymptomatic carriage with/without the formation of an immune response; definition of syndromic complexes and their periodization; options for the uncomplicated and complicated course of the disease; outcomes, including recovery with/without the formation of specific immunity and thanatogenesis, with the search for evidence of direct or indirect involvement of SARS-CoV-2 virus in adverse outcomes.The underestimation of the host's responses to the effects of beta-coronavirus has led to syndromic polypharmacy using more than 30 drugs with anti-inflammatory, antiviral, antibacterial, anticoagulant, immunosuppressive, and other effects, including passive immunotherapy with plasma of recovered patients or therapeutic exchange plasmapheresis. Seven months of the fight against COVID-19 led, as one would expect, to the proven effect of only tough anti-epidemic measures, personal protective measures and hygiene in the absence of effective treatment and prevention measures. In fact, an empirical selection of national and international treatment protocols with a combination of non-specific syndromic drugs is underway in the world.The critical review discusses scientific data and hypotheses of the origin of a new coronavirus infection, human ontogenetic response to infection with SARS-CoV-2, and emerging bioinformatic concepts of the pathogenesis of the disease and approaches to pathogenetic treatment.

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Section: о б з о р ы л и т е р а т у р ы || L I T E R a T U R E R E V I E W Sunclassified

Coronavirus infection COVID-19. Scientific challenges and possible ways to treat and prevent the disease

Румянцев

2020

Ross. ž. det. gematol. onkol.

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“…Болезни присвоено название «COronaVIrus Disease 2019» (COVID-19), а воз-будителю -официальное название SARS-CoV-2 [1,9]. У детей течение COVID-19 отличается от взрослых: реже наблюдаются тяжелые и осложненные проявления, летальные исходы, в большинстве случаев заболевание протекает бессимптомно или с малой клинической симптоматикой, характерной для сезонных респираторно-вирусных инфекций [3,6,8].…”

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The outbreak of the new coronavirus infection in pediatric TB department

Губкина

Петракова

Yukhimenko

et al. 2020

Tuberk. bolezni lëgk.

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The objective: to analyze the course of the new coronavirus infection (COVID-19) in children with active respiratory tuberculosis. Subjects and methods. The article describes results of retrospective analysis of the course of the new coronavirus infection in 25 children (3-12 years old) with active respiratory tuberculosis during the outbreak of COVID-19 in an in-patient TB unit.Results. 24 (96%) persons got infected after the close exposure to the coronavirus infection, and 1 (4%) child didn't get infected. The diagnosis was verified by polymerase chain reaction (detection of RNK of SARS-CoV-2) in 33.3%, by enzyme immunoassay (detection of IgG antibodies to SARS-CoV-2 in 1 month after quarantine removal) in 100%. 58.3% of children with respiratory tuberculosis (14 people) infected with coronavirus infection had minimal respiratory symptoms, that did not differ from signs of other respiratory viral infections; clinical manifestations of the disease were completely absent in 41.7% (10) patients. Coronavirus pneumonia was diagnosed in 4 (16.7%) children who suffered from COVID-19, they had no clinical signs of lower respiratory tract disorders and no body temperature increase; 3 patients had no signs of respiratory viral infection; in all cases, the lung damage detected by computed tomography didn't exceed 10%. In 2 months after the removal of quarantine, no IgG antibodies to SARS-CoV-2 were detected in 2 out of 10 examined children (20.0%), thus there was a chance for re-infection. No mutual aggravating effect of coronavirus infection and tuberculosis was revealed in their combination over the entire observation period (4 months).

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Tuberculosis and COVID-19 in Children and Adolescents. Two Waves of the Pandemic: Experiences and Conclusions

Ovsyankina

Панова

Губкина

et al. 2022

Tuberk. bolezni lëgk.

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The objective of the study: to investigate diagnostics, course and outcomes of COVID-19 in children and adolescents with tuberculosis in relation to the epidemic control activities.Subjects and Methods: during the pandemic of coronavirus infection (the first and second waves), 83 patients aged 2 to 17 years (41 children and 42 adolescents) were followed up. 62 (74.7%) children got infected with the novel coronavirus infection among 82 patients treated at the clinic over this time.Results. COVID-19 has been found to be highly contagious in the group of children staying in the ward, employees working with children and adolescents were the source of infection. Compliance with sanitary and infection control activities allows reducing the likelihood of the viral infection spread in the group of children and adolescents. The respiratory syndrome is not a major sign for the diagnosis of COVID-19 in children and adolescents with respiratory tuberculosis. For the diagnosis of COVID-19, targeted immunological and microbiological tests are important. Most patients with clinical manifestations of the coronavirus infection (79.4% of cases) were diagnosed with a mild course of the disease. Co-infection (tuberculosis and COVID-19) caused no mutual aggravation. No adjustment of chemotherapy was required, and the duration of treatment didn’t increase including short-course chemotherapy regimens with multiple/extensive drug resistant Mycobacterium tuberculosis and in patients after surgery.

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Coronavirus Infection in Children

Cited by 11 publications

References 0 publications

Coronavirus infection COVID-19. Scientific challenges and possible ways to treat and prevent the disease

Coronavirus infection COVID-19. Scientific challenges and possible ways to treat and prevent the disease

The outbreak of the new coronavirus infection in pediatric TB department

Tuberculosis and COVID-19 in Children and Adolescents. Two Waves of the Pandemic: Experiences and Conclusions

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