Coronavirus disease 2019 population-based prevalence, risk factors, hospitalization, and fatality rates in southern Brazil

Picon, Rafael V.; Carreno, Ioná; Silva, André Anjos da; Mossmann, Márcio; Laste, Gabriela; Domingues, Guilherme de Campos; Heringer, Lara Faria Fernandes; Gheno, Brenda Rodrigues; Alvarenga, Leticia Leão; Conte, Magali

doi:10.1016/j.ijid.2020.09.028

Cited by 16 publications

(20 citation statements)

References 40 publications

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“…The mortality rate among the hospitalized patients in this study (13.72%) was also significantly lower compared with reports in Brazil (39.6%) 2 and New York, USA (21%). 12 India has globally one of the highest recovery and the lowest COVID-19 mortality rates.…”

Section: Discussioncontrasting

confidence: 64%

“…It is well-established that although most patients with coronavirus disease 2019 (COVID-19) have mild-moderate symptoms and show recovery, a significant proportion require timely hospitalization to reduce the risk of complications and mortality. 1,2 The state of Delhi comprising the Indian capital city with a population of 19.6 million had recorded 0.48 million COVID-19 cases and 7614 associated deaths as of November 16, 2020. 3 Previous studies show that the risk of severe COVID-19 illness and fatality is higher among men, elderly, and in individuals with comorbidities, especially diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Outcomes among 10,314 hospitalized COVID‐19 patients at a tertiary care government hospital in Delhi, India

Malhotra

Basu

Sharma

et al. 2021

Journal of Medical Virology

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A significant proportion of patients with coronavirus disease 2019 require timely hospitalization to reduce the risk of complications and mortality. We describe the trends of the age and gender stratified outcomes among hospitalized COVID-19 patients with moderate to severe illness at the largest dedicated tertiary care COVID-19 government hospital in New Delhi, India. A retrospective cohort study through secondary data analysis from in-patient hospital data of patients admitted from April 1 to November 15, 2020 was conducted. The data of 10,314 laboratory-confirmed patients with COVID-19 was analyzed, of which 8899 (86.28%) were discharged after recovery, and 1415 (13.72%) died. The mean (SD) age of the hospitalized patients was 46.43 (18.74) years (n = 10,309) including 6031 (58.50%) male and 4278 (41.50%) female patients (n = 10,309). On bivariate analysis, increasing age was associated with significantly higher odds of mortality in both gender (p < .001). The mortality rate in female patients was lower (11.92%) compared with male patients (15.75%) (p = .675). However, elderly women had the highest odds of mortality (p < .001), indicating the possible role of delayed health seeking behavior, secondary to familial, and social neglect. Mortality in the patients with COVID-19 also occurred early after admission suggesting rapid deterioration, delayed reporting by patients, or their late referral from other health facilities.However, the overall statewide recovery rate showed steady improvement since the onset of the pandemic. In contrast, the recovery rate among the moderatesevere cases that were hospitalized at this tertiary care center during the same period reflected a lower nonspecific zigzag pattern indicating limited effectiveness of the COVID-19 treatment regimens.

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Section: Discussioncontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Outcomes among 10,314 hospitalized COVID‐19 patients at a tertiary care government hospital in Delhi, India

Malhotra

Basu

Sharma

et al. 2021

Journal of Medical Virology

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“…A number of studies reporting anti-SARS-CoV-2 seroprevalence data have been published (Barzin et al, 2020 ; Biggs et al, 2020 ; Chen et al, 2020 ; Hallowell et al, 2020 ; Kshatri et al, 2020 ; Lai et al, 2020 ; Majdoubi et al, 2020 ; Makaronidis et al, 2020 ; Murhekar et al, 2020 ; Picon et al, 2020 ; Rudberg et al, 2020 ; Song et al, 2020 ; Squeri et al, 2020 ; Stadlbauer et al, 2020 ; Takita et al, 2020 ; Wells et al, 2020 ), including a few with respect to blood donors (Amorim Filho et al, 2020 ; Erikstrup et al, 2020 ; Fiore et al, 2020 ; Fischer et al, 2020 ; Gallian et al, 2020 ; Ng et al, 2020 ; Percivalle et al, 2020 ; Younas et al, 2020 ). Our results are consistent with these reports in that seroprevalence estimates are generally low, albeit often several-fold higher than cumulative COVID-19 incidence rates.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 seroprevalence among blood donors in Québec, and analysis of symptoms associated with seropositivity: a nested case-control study

Lewin

Therrien

Serres

et al. 2021

Can J Public Health

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Objectives A substantial proportion of individuals infected with SARS-CoV-2 do not experience noticeable symptoms typical of COVID-19. Our objectives were to evaluate the impact of the first wave of the pandemic in Québec by measuring SARS-CoV-2 antibody seroprevalence in a convenience sample of healthy blood donors and to study the association between seropositivity and the occurrence of COVID-19 symptoms. Methods The study design was a cross-sectional serological survey with a nested case-control study. Residual blood samples from donations collected between May 25 and July 9, 2020 (well before vaccination rollout) in the province of Québec were tested for anti-Spike RBD antibodies by ELISA. Seropositive donors and a control group of seronegative donors were questioned about prior COVID-19 symptoms. All qualified blood donors were eligible for participation. Results A total of 7691 blood donors were included in the study. After adjustments, the seroprevalence rate was 2.2% (95% CI 1.9-2.6). Seropositive donors reported one or more symptoms in a proportion of 52.2% (95% CI 44.2-60.1); this proportion was 19.1% (95% CI 13.4-26.1) among seronegative donors, suggesting that approximately 50-66% of all infections were asymptomatic. Univariate analysis of associations between symptoms and seropositivity revealed that except for rhinorrhea, all symptoms were significantly associated with seropositivity. Conclusion Assuming that blood donors are fairly representative of the general adult population, this study shows that less than 3% of 18-69-year-olds have been infected during the first wave of the pandemic in the province of Québec. Our data also confirm that many infections escaped detection, including a substantial proportion that were asymptomatic.

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“…However, to date we are aware of only two studies in any LMIC that estimate age-specific IFRs, and these are limited to small or non-representative samples. The sample in Picon et al ( 24 ) is representative for one city in Brazil; the sample in Verity et al ( 25 ) is limited to repatriated international residents leaving Wuhan Province (China) in a two-day span. Thus, this paper is the first to provide representative age- and sex-specific IFR estimates for a large population (the combined population of Mumbai and Karnataka is 73 million) in a low- or middle-income setting.…”

mentioning

confidence: 99%

“…IFR estimates almost universally rely upon large-scale seroprevalence samples drawn from the larger population, matched to administrative data on deaths. There have been very few seroprevalence studies (listed above) that can be matched to mortality counts in lower-income settings and none with sufficient sample size to calculate age-specific IFRs with any granularity ( 24 ). But IFRs that are not age-specific are difficult to compare across contexts, because the age pattern of infection may vary and aggregate IFRs will be larger in places where older people have a larger share of infections.…”

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confidence: 99%

Representative Estimates of COVID-19 Infection Fatality Rates from Three Locations in India

Cai

Novosad

Tandel³

et al. 2021

Preprint

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There are very few estimates of the age-specific infection fatality rate (IFR) of SARS-CoV-2 in low- and middle-income countries. India reports the second highest number of SARS-CoV-2 infections in the world. We estimate age-specific IFR using data from seroprevalence surveys in Mumbai (population 12 million) and Karnataka (population 61 million), and a random sample of economically distressed migrants in Bihar with mortality followup. Among men aged 50–89, IFR is 0.12% in Karnataka (95% C.I. 0.09%–0.15%), 0.53% in Mumbai (0.52%–0.54%), and 5.64% among migrants in Bihar (0–11.16%). IFR in India is approximately twice as high for men as for women, is heterogeneous across contexts, and rises much less at older ages than in comparable studies from high income countries.

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Coronavirus disease 2019 population-based prevalence, risk factors, hospitalization, and fatality rates in southern Brazil

Cited by 16 publications

References 40 publications

Outcomes among 10,314 hospitalized COVID‐19 patients at a tertiary care government hospital in Delhi, India

Outcomes among 10,314 hospitalized COVID‐19 patients at a tertiary care government hospital in Delhi, India

SARS-CoV-2 seroprevalence among blood donors in Québec, and analysis of symptoms associated with seropositivity: a nested case-control study

Representative Estimates of COVID-19 Infection Fatality Rates from Three Locations in India

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