Coronavirus Disease 2019 in Kidney Transplant Recipients: Single-Center Experience and Case-Control Study

Clinical insights into the role of immunosuppression and its disturbances in solid organ transplant recipients with coronavirus disease 2019

“…Thus, a possible explanation is decreased tacrolimus metabolism in the liver, although liver enzymes during these tacrolimus level disturbances remained within the normal range. This finding is in line with the latest observations concerning both specific liver ultrastructural changes caused by SARS-CoV-2 [26] and elevated tacrolimus or sirolimus levels in most of nine otherwise stable KTRs during COVID-19 [27]. If so, to prevent or reduce the severity of kidney injury during COVID-19, current calcineurin inhibitor blood levels should be highlighted, in addition to the already routine use of mycophenolate dose reduction or cessation according to the ERA-EDTA Descartes guidelines [6].…”

“…The number of comorbidities in deceased patients with different organs transplanted was similar. Except one patient died after liver transplantation, the median time from COVID-19 diagnosis to death was significantly shorter in the KTR (n=9) than in the OHT (n=6) subgroup [9 (6-21) vs. 33 (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) days, P = 0.02].…”

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

“…Overall, 590,375 enrolled patients were included (5,759 SOT recipients vs. 584,616 general populations). Six studies were prospective and twenty-five retrospective [ 4 , 5 , 6 , 7 , 9 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Sixteen were conducted in Northern America (15 in USA and one in Canada), fourteen in Europe, and one in Asia.…”

“…A total of 17 studies (3,752 SOT recipients vs. 159,745 patients in general population) provided adjusted data for 30-day mortality rate [ 5 , 6 , 7 , 9 , 14 , 15 , 16 , 20 , 21 , 23 , 25 , 26 , 27 , 28 , 30 , 31 , 33 ]. In 11 studies, adjustment for confounders was performed by using a propensity score analysis, while exact matched cohorts and regression analysis were implemented in 5 and 1 study, respectively.…”

Use of anti-spike monoclonal antibodies in kidney transplant recipients with COVID-19: Efficacy, ethnic and racial disparities

“…We identified KTR diagnosed with COVID‐19 at Brown University‐affiliated hospitals between March 1, 2020 and April 30, 2021. Details of our transplant population and protocols were previously described 18 …”