Coronavirus Disease 2019 (COVID-19) in a Patient with Disseminated Histoplasmosis and HIV—A Case Report from Argentina and Literature Review

Messina, Fernando; Marín, Emmanuel; Cáceres, Diego H.; Romero, Mercedes; Depardo, Roxana; Priarone, María Marta; Rey, Laura; Vázquez, Mariana; Verweij, Paul E.; Chiller, Tom; Santiso, Gabriela

doi:10.3390/jof6040275

Cited by 46 publications

(54 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because SARS-CoV-2 and treatments such as dexamethasone or tocilizumab can impair the immune system, some researchers anticipated the possibility of fungal superinfection among COVID-19 patients ( 3 – 6 ). As of August 2020, researchers have documented COVID-19–associated pulmonary aspergillosis (CAPA) ( 7 – 9 ), invasive candidiasis ( 10 ), coccidioidomycosis ( 11 ), fusariosis ( 12 ), histoplasmosis ( 13 ), mucormycosis ( 14 ), pneumocystosis ( 15 ), and saccharomycosis ( 16 ). Varying cumulative rates of CAPA have been described, including rates of 0.7%–7.7% among COVID-19 patients ( 17 , 18 ), 2.5%–39.1% among ICU patients with COVID-19 ( 19 , 20 ), and 3.2%–29.6% among COVID-19 patients on mechanical ventilation ( 7 , 17 ).…”

mentioning

confidence: 99%

COVID-19–Associated Pulmonary Aspergillosis, March–August 2020

Salmanton‐García¹,

Sprute²,

Stemler³

et al. 2021

Emerg. Infect. Dis.

205

219

View full text Add to dashboard Cite

Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease–associated pulmonary aspergillosis (CAPA) worldwide during March–August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%.

show abstract

mentioning

confidence: 99%

COVID-19–Associated Pulmonary Aspergillosis, March–August 2020

Salmanton‐García¹,

Sprute²,

Stemler³

et al. 2021

Emerg. Infect. Dis.

205

219

View full text Add to dashboard Cite

show abstract

“…Respecto a las histoplasmosis, uno de los casos fue diagnosticado por visualización de levaduras de Histoplasma capsulatum (Hc) en el examen directo con tinción de Giemsa del esputo y además presentó el antígeno urinario de galactomanano de histoplasma positivo (IMMY®) (21). El otro caso fue diagnosticado por detección de anticuerpos de Histoplasma capsulatum (contrainmunoelectroforesis) y además tuvo PCR específica positiva en sangre (PCR anidada: gen HcP 100 de Hc que codifica una proteína implicada en la infección y supervivencia de Hc) (17), también tuvo antígeno urinario positivo.…”

Section: Resultsunclassified

“…En los casos de criptococosis e histoplasmosis se emplearon las metodologías habituales de la Unidad Micología del Hospital F. J. Muñiz (17,19,20,21).…”

Section: Diagnósticounclassified

Infecciones fúngicas en pacientes con COVID-19

Messina¹,

Marín²,

Valerga³

et al. 2021

ASEI

Self Cite

View full text Add to dashboard Cite

En diciembre de 2019 se identificó en Wuhan, China, un nuevo coronavirus denominado SARS-CoV-2, agente causal de la epidemia de neumonía atípica COVID-2019, que el 11 de marzo de 2020 fue declarada pandemia por la OMS. Hasta el 30 de septiembre de 2020, en Argentina fueron confirmados 751.001 casos y más de 16.937 muertes.La frecuencia y el impacto de las coinfecciones que afectan a los pacientes infectados por SARS-Cov-2 se ha estudiado junto con el avance de la pandemia. Entre las debidas a hongos se encuentran las fungemias por Candida sp, la aspergilosis invasora, las micosis sistémicas endémicas y la neumocistosis. Presentamos las distintas coinfecciones micosis-COVID-19 que fueron asistidas en nuestra institución entre abril y septiembre de 2020, y se realiza un análisis de las características de estas infecciones en pacientes con y sin sida. En este período se internaron 2837 pacientes, 2287 tuvieron diagnóstico confirmado de COVID-19. La coinfección de COVID-19 con micosis pulmonares o sistémicas fue menor al 1%. Dieciocho pacientes presentaron infecciones fúngicas pulmonares o sistémicas. Ocho padecieron candidemias, cinco criptococosis meningeas, dos histoplasmosis, dos aspergilosis invasoras agudas probables y una aspergilosis pulmonar crónica. La estadía prolongada en terapia intensiva facilitó las fungemias por Candida sp, los casos de histoplasmosis y criptococosis parecen relacionarse con la enfermedad avanzada por VIH y no con COVID-19. Los enfermos con un componente inflamatorio basal alto con neumonía grave por coronavirus se relacionan más con micosis invasoras que los enfermos VIH positivos con niveles bajos de LTCD4+.

show abstract

“…(Jehangir et al 2015 ). In light of current pandemic, it is important to emphasize that two cases of histoplasmosis co-infection on immunocompromised AIDS patients with COVID-19 have been reported recently (Messina et al 2020 ; Basso et al 2020 ).…”

Section: Bat (Guano) Mycobiotamentioning

confidence: 99%

The microbiome of bat guano: for what is this knowledge important?

Dimkić

Fira

Janakiev

et al. 2021

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation of the bats in urban areas allowing easy interaction with other animals, expansion, and emergence of new zoonotic disease outbreaks potentially harmful to humans. Therefore, getting new insights in the microbiome of bat guano from different places represents an imperative for the future. Furthermore, the use of novel high-throughput sequencing technologies allows better insight in guano microbiome and potentially indicated that some species could be typical guano-dwelling members. Bats are well known as a natural reservoir of many zoonotic viruses such as Ebola, Nipah, Marburg, lyssaviruses, rabies, henipaviruses, and many coronaviruses which caused a high number of outbreaks including ongoing COVID-19 pandemic. Additionally, many bacterial and fungal pathogens were identified as common guano residents. Thus, the presence of multi-drug-resistant bacteria as environmental reservoirs of extended spectrum β-lactamases and carbapenemase-producing strains has been confirmed. Bat guano is the most suitable substrate for fungal reproduction and dissemination, including pathogenic yeasts and keratinophilic and dimorphic human pathogenic fungi known as notorious causative agents of severe endemic mycoses like histoplasmosis and fatal cryptococcosis, especially deadly in immunocompromised individuals. This review provides an overview of bat guano microbiota diversity and the significance of autochthonous and pathogenic taxa for humans and the environment, highlighting better understanding in preventing emerging diseases. Key points& Bat guano as reservoir and source for spreading of autochthonous and pathogenic microbiota & Bat guano vs. novel zoonotic disease outbreaks & Destruction of bat natural habitats urgently demands increased human awareness

show abstract

Coronavirus Disease 2019 (COVID-19) in a Patient with Disseminated Histoplasmosis and HIV—A Case Report from Argentina and Literature Review

Cited by 46 publications

References 58 publications

COVID-19–Associated Pulmonary Aspergillosis, March–August 2020

COVID-19–Associated Pulmonary Aspergillosis, March–August 2020

Infecciones fúngicas en pacientes con COVID-19

The microbiome of bat guano: for what is this knowledge important?

Contact Info

Product

Resources

About