Coronavirus disease-19 (COVID-19) associated with acute necrotising pancreatitis (ANP)

Abstract

Coronavirus is a severe infectious disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has led to increased mortality worldwide. Multiple reports have been published citing that gastrointestinal symptoms are common in patients with COVID-19 infection. It has also been found that the ACE2 receptor of SARS-CoV-2 is expressed more in the pancreas than the lungs. Despite this, little attention has been paid to the extent and details of pancreatic injury caused by COVID-19. Lack of awareness regarding the COVID-19 status of patients presenting with pancreatitis may expose healthcare workers to SARS-CoV-2 while performing interventions to manage complications of pancreatitis such as necrosis. We report a case of COVID-19-induced acute necrotising pancreatitis in the absence of any known risk factors.

Acute pancreatitis in a patient with COVID-19

“… 11 Further supportive data are provided by Meireles et al 12 in a report of a patient with COVID-19 pneumonia who developed acalculous pancreatitis on the 11th day of the disease in whom other viral causes have been ruled out by laboratory investigations. 12 Additional similar cases were reported by Aloysius et al , 13 Kataria et al , 14 Mazrouei et al , 15 Karimzadeh et al , 16 Hadi et al , 17 Kumaran et al 18 and Wang et al . 19 …”

Acute Pancreatitis in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19)

“…Pancreas 2020;49:e108–9. doi: 10.1097/MPA.0000000000001696) 5 , 6 of acute pancreatitis in the setting of COVID-19, with suggestion of pancreatic injury occurring in up to 17% of afflicted patients. 7 , 8 A review of PubMed using search terms “SARS-CoV-2,” “COVID-19,” “pregnancy,” and “pancreatitis” from inception through November 8, 2020, identified limited data on acute pancreatitis in a previously healthy pregnant patient with COVID-19 infection.…”

Implications of SARS‐CoV‐2 infection for neurogastroenterology

“…113 Pancreatic involvement, defined as an increase in serum amylase and/or lipase or overt acute pancreatitis, has also been described in few reports or case series. [115][116][117][118] In the largest retrospective case series, elevated serum lipase was found in 14/83 cases (16.8%), and this was correlated with higher rates of admission to the intensive care unit and need for intubation. 117 However, the number of cases described is rather small and most patients were severely obese.…”