Coronary vasospasm, multiple coronary thrombosis, unstable angina and essential thrombocytosis

Functional and morphological cardiac changes in myeloproliferative disorders (clinical study)

“…The contribution of elevated platelet counts to thromboembolism is controversial [6,42,43]. A number of functional and biochemical abnormalities of platelets have been reported in MPD [3,6,11,44,45]. Increased red cell counts and hyperviscosity are considered more important than the increased platelet counts in the formation of thrombus [3,21,46].…”

Multivessel coronary thrombosis, acute myocardial infarction, and no reflow in a patient with essential thrombocythaemia

“…Laboratory data showed 10.8 × 10 3 /mm 3 leukcocytosis without an increase of creatine kinase. Her platelet count was raised at 69 × 10 4 /mm3 and her haemoglobin was 10.2 g/l.…”

“…Left ventriculography showed anteroapical hypokinesis with left ventricular ejection fraction of 68%. She was discharged, without chest pain, with a platelet count of 60.6 × 10 4 /mm3 and on aspirin (81 mg/day), ticlopidine (200 mg/day), and busulfan (2 mg/day). She developed no major bleeding complications.…”

Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: A case report with review

“…Fewer than 20 cases of essential thrombocytosis with involvement of coronary arteries leading to acute coronary syndromes or myocardial infarction have been reported [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. The association between essential thrombocytosis and coronary artery disease was first reported by Saffitz et al [12].…”

“…The majority of the case reports about essential thrombocytosis and acute coronary syndromes/acute myocardial infarction are due to the occlusion of the left anterior descending artery [16]. The left anterior descending artery was reported to be involved in ten patients [12][13][14]16,17,19,21,22,25,26] and the right coronary artery [12,14,17,18] was involved in four patients. The left main coronary artery was involved in three patients [18,23,24].…”