Coronary slow-flow causing transient myocardial hypoperfusion in patients with cardiac syndrome X: Long-term clinical and functional prognosis

Fragasso, Gabriele; Chierchia, Sergio; Arioli, Francesco; Carandente, O; Gerosa, Stefano; Carlino, Mauro; Palloshi, Altin; Gianolli, Luigi; Calori, Giliola; Fazio, Ferruccio; Margonato, Alberto

doi:10.1016/j.ijcard.2008.06.070

Cited by 50 publications

(22 citation statements)

References 44 publications

(41 reference statements)

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“…Our study has revealed that oxidative stress is higher in coronary slow flow group. This finding together with previous studies comparing two diseases with respect to prognosis (19), supports the notion that coronary slow flow as a syndrome X sub-group has a worse prognosis than syndrome X.…”

Section: Discussionsupporting

confidence: 87%

The effect of antioxidant enzyme levels and exercise on syndrome X and coronary slow flow phenomenon: an observational study

Kaplan¹,

Meriç²,

Acar³

et al. 2013

Anadolu Kardiyol Derg

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Objective: In this study the antioxidant enzyme [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) ] levels at rest in patients with syndrome X and coronary slow flow are measured. Then it has been investigated whether there is any enzymatic difference between the normal controls and syndrome X patients or patients with coronary slow flow and ascertain if exercise has any effects on the antioxidant enzyme levels. Methods: Fifty-five patients were included in this prospective observational controlled study. Patients were divided into 3 groups: Group 1-normal controls (n=20); Group 2-patients with coronary slow flow (n=20); and Group 3-patients diagnosed with syndrome X (n=15). In all patients, blood samples were collected at rest and after maximal exercise. The antioxidant enzymes (SOD, CAT, Gpx) in the erythrocytes were studied for these three groups of blood sample. Statistical analysis was performed using Student t-test, Mann-Whitney U and Chi-square tests, KruskalWallis variance analysis and ANOVA. Results: Under basal conditions the lowest SOD and GPx levels were measured in the 2 nd Group, whereas significant differences in paired comparisons were observed only between the 2 nd and 3 rd Groups (p=0.024 vs. p<0.01, respectively) during paired comparisons. The postexercise SOD levels were decreased significantly in the 3 rd Groups when compared with the basal concentrations (p=0.014), however no significant pre-and post-exercise differences were observed in the CAT and GPx concentrations (p>0.05). Conclusion: The post-exercise SOD level when compared with basal SOD levels were decreased significantly in the syndrome X group, however no differences were observed between the other groups. This can be interpreted as the reduction in the exercise related symptoms and ischemic findings are resulting from the decrease of SOD activity. (Anadolu Kardiyol Derg 2013; 13: 641-6) Key words: Coronary slow flow, syndrome X, antioxidant enzymes Original Investigation Özgün Araşt›rma 641ÖZET Amaç: Bu çalışmada, sendrom X ve yavaş koroner akım hastalarında istirahatte antioksidan enzim [katalaz (CAT), süperoksid dismutaz (SOD) ve glutatyon peroksidaz (GPx)] düzeyleri ölçülerek normal kontrollerle fark gösterip göstermediği, egzersizin enzim düzeylerine etkisi olup olmadı-ğı araştırılmak istenmiştir.Yöntemler: Prospektif kontrollü gözlemsel bu çalışmaya 55 kişi alındı. Hastalar, normal kontroller (Grup 1, n= 20), koroner yavaş akımı olan hastalar (Grup 2, n=20) ve Sendrom X tanısı konan hastalar (Grup 3, n=15) olmak üzere 3 gruba ayrıldı. Tüm hastalardan istirahatte ve maksimum efor sonrası kanlar alındı ve eritrosit içindeki antioksidan enzimler (SOD, CAT, GPx) çalışıldı. İstatistiksel analiz Student t-testi, Mann-Whitney U, Ki-kare testi, Kruskal-Wallis varyans analizi ve ANOVA (post-hoc) kullanılarak yapıldı. Bulgular: Bazal şartlarda ölçülen SOD ve GPx değerleri en düşük olarak Grup 2'de saptanırken, ikili karşılaştırmada yalnızca Grup 2 ve 3 arasın-da anlamlı fark vardı (p sırasıyla 0,02...

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Section: Discussionsupporting

confidence: 87%

The effect of antioxidant enzyme levels and exercise on syndrome X and coronary slow flow phenomenon: an observational study

Kaplan¹,

Meriç²,

Acar³

et al. 2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

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“…11,12 Moreover, on a recent report associated with SCF and with scintigraphic signs of ischemia in the related coronary territory, a worse cardiovascular prognosis was demonstrated. 13 It was suggested that SCF without evident cause might represent a new entity of coronary heart disease. 14 In the current study, we aimed to evaluate coronary blood flow in patients with COPD having angiographically proven normal coronary arteries by means of Thrombolysis In Myocardial Infarction (TIMI) frame count.…”

Section: Editorial P 254mentioning

confidence: 99%

Documentation of Impaired Coronary Blood Flow in Chronic Obstructive Pulmonary Disease Patients

Selçuk

Maden

Selçuk

et al. 2010

Circ J

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“…Patients with SCF often exhibit angina pectoris or acute coronary syndrome, have high rates of re-hospitalization and are more likely to be diagnosed with other cardiovascular-related diseases [2,3].…”

Section: Introductionmentioning

confidence: 99%

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

Li¹,

Zhang

Liang

et al. 2018

Cardiol J.

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Background: To improve therapy for slow coronary flow (SCF), the effects of hyperbaric oxygen (HBO) therapy on vascular endothelial function in divided into two groups according to the following treatment: HBO group (n = 48) and the control group (n = 50). Patients in the control group were administrated with conventional treatment, while those in the HBO group were administrated HBO therapy for 4 weeks in addition to conventional treatment. To evaluate the effects of HBO on vascular endothelial functions, plasma levels of nitric oxide (NO), calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1), high sensitivity C-reactive protein (hsCRP) as well as endothelial-dependent flowmediated vasodilation (FMD) of the brachial artery were measured in both groups before and after their respective treatments.Results: There were no significant differences in plasma levels of NO, CGRP, hsCRP (Cardiol J 2018; 25, 1: 106-112)

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Coronary slow-flow causing transient myocardial hypoperfusion in patients with cardiac syndrome X: Long-term clinical and functional prognosis

Cited by 50 publications

References 44 publications

The effect of antioxidant enzyme levels and exercise on syndrome X and coronary slow flow phenomenon: an observational study

The effect of antioxidant enzyme levels and exercise on syndrome X and coronary slow flow phenomenon: an observational study

Documentation of Impaired Coronary Blood Flow in Chronic Obstructive Pulmonary Disease Patients

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

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