Coronary Risk in Patients with Endstage Renal Disease

Goldberg, Andrew P.; Tindira, Carol A.; Harter, Herschel R.

doi:10.1097/00005344-198200042-00016

Cited by 8 publications

(1 citation statement)

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“…This may in part explain why hypertension complicated with hyperlipidemia predisposed to more serious cardiovascular diseases such as atherosclerosis. 15,65,66 ■ CONCLUSIONS In summary, a stretchable sensing interface based on the Au NT network decorated with uniform and tiny Pt NPs was designed for real-time monitoring of H 2 O 2 release in endothelial mechanotransduction. In the deliberate structure, percolating Au NTs skeleton enabled excellent and stable electrochemical performance under various mechanical deformations, while decorated Pt NPs provided superior catalytic property toward the oxidation of H 2 O 2 .…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Stretchable Electrode Based on Au@Pt Nanotube Networks for Real-Time Monitoring of ROS Signaling in Endothelial Mechanotransduction

Fan

Qin

et al. 2020

Anal. Chem.

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Vascular endothelial cells (ECs) are natively exposed to dynamic cyclic stretch and respond to it by the production of vasoactive molecules. Among them, reactive oxygen species (ROS) are closely implicated to the endothelial function and vascular homeostasis. However, the dynamic monitoring of ROS release during endothelial mechanotransduction remains a steep challenge. Herein, we developed a stretchable electrochemical sensor by decoration of uniform and ultrasmall platinum nanoparticles (Pt NPs) on gold nanotube (Au NT) networks (denoted as Au@Pt NTs). The orchestrated structure exhibited prominent electrocatalytic property toward the oxidation of hydrogen peroxide (H 2 O 2 ) (as the most stable ROS) while maintaining excellent mechanical compliance of Au NT networks. Moreover, the favorable biocompatibility of Au NTs and Pt NPs promoted the adhesion and proliferation of ECs cultured thereon. These allowed in situ inducing ECs mechanotransduction and synchronously real-time monitoring of H 2 O 2 release. Further investigation revealed that the production of H 2 O 2 was positively correlated with the applied mechanical strains and could be boosted by other coexisting pathogenic factors. This indicates the great prospect of our proposed sensor in exploring ROS-related signaling for the deep understanding of cell mechanotransduction and vascular disorder.

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Section: ■ Results and Discussionmentioning

confidence: 99%