Comparison of the effects of prazosin versus propranolol on plasma lipoprotein lipids in patients receiving hemodialysis

Harter, Herschel R.; Meltzer, Victor N.; Tindira, Carol A.; Naumovich, Anna D.; Goldberg, Andrew P.

doi:10.1016/0002-9343(86)90164-6

Cited by 16 publications

(3 citation statements)

References 25 publications

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“…Plasma triglyceride levels fall in hypertensive patients (Coto et d. 1987;Swilocki et al 1989) or rats (Reaven and Ball'Aglio 1982) treated with prazosin. It has been postulated that activation of LPL (Harter et al 1986) or reduction in VLDE secretion rates (Reaven and Dal19Ag%io 1982) may occur with prazosin, which results in a decrease in VEDL and ultimately a reduction in triglyceride. However, despite the reduction in plasma triglycerides in these prmosintreated diabetic rats, there was no concomitant improvement in cardiac function.…”

Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemia in experimental diabetes: relationship to cardiac dysfunction

Rodrigues

Grassby²,

Battell³

et al. 1994

Can. J. Physiol. Pharmacol.

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The incidence of mortality from cardiovascular disease is higher in diabetic patients. The objective of the present investigation was to test the hypothesis that the diabetes-induced depression in cardiac function may be due to hypertriglyceridemia. Hyperlipidemia and a depressed left ventricular developed pressure and rate of increase and decrease of ventricular pressure (+/- dP/dt) were produced in isolated hearts from rats made diabetic with streptozotocin compared with hearts from control animals. This depressed cardiac performance was successfully prevented by hydralazine treatment (for 3 weeks), which also lowered plasma triglyceride levels and suggested that hyperlipidemia may be important in altering cardiac function in experimental diabetic rats. The beneficial effects of clofibrate, verapamil, prazosin, enalapril, and benazepril administration were then studied in diabetic rats. The treatments (with the exception of enalapril) significantly reduced plasma triglyceride levels but did not prevent the onset of heart dysfunction in chronically diabetic rats. These studies suggest that in the chronically diabetic rat, hypertriglyceridemia may not be as important as previously suggested, in the development of cardiac dysfunction. Since acute dichloroacetate perfusion improves cardiac function in 6 week (but not 24 week) diabetic rats, it appears more likely that improving myocardial glycose utilization is more critical than triglyceride lowering, in preventing cardiac dysfunction in the diabetic rat at this time point.

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Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemia in experimental diabetes: relationship to cardiac dysfunction

Rodrigues

Grassby²,

Battell³

et al. 1994

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Gonen and colleagues have reported that extensive in vitro carbamylation ofLDL abolished the ability ofLDL to be recognized by the LDL receptor [64]. Indirect evidence for modification of the receptor-binding domain of LDL in uremia was given by degradation studies using cultured fibroblasts, where LDL , isolated from human uremic subjects on dialysis, was less efficient than normal LDL in competing for degradation of 125 1 LDL by fibroblasts [65]. However, no difference in the amino acid composition between normal and uremic LDL was detected.…”

Section: Metabolic Fatementioning

confidence: 99%

“…Prazosin has also been shown to induce LVH regression [13]. a-1-blockers have a major advantage over other antihypertensive agents regarding lipid metabolism: they may ameliorate the lipid profile with an increase in HDL [125,126]. Thus, even if they are not considered a first choice in ESRD arterial hypertension [89], they remain a good alternative that is well tolerated by many patients [124] and that has no biochemical side effects.…”

Section: Alpha-blockersmentioning

confidence: 99%