Coronary involvement in Cogan's syndrome

Cogan's syndrome in childhood

“…No reports of coronary involvement in childhood were found in the literature. Pericardial disease was reported in two patients with CS [5,9]. Four pediatric patients (including ours) [2,5,9] had aortitis with aortic regurgitation.…”

“…Pericardial disease was reported in two patients with CS [5,9]. Four pediatric patients (including ours) [2,5,9] had aortitis with aortic regurgitation. In one patient, no information was available [7].…”

“…Aortic wall and aortic valve lea¯ets complicated by aortitis with aortic dilatation and valvular insuciency developed in 10% of young adult patients within weeks to years after the onset of CS [1,2,7,9]. Forty percent of patients with cardiovascular disease had had coronary involvement in the form of proximal coronary artery occlusion or coronary artery vasculitis [9].…”

“…Forty percent of patients with cardiovascular disease had had coronary involvement in the form of proximal coronary artery occlusion or coronary artery vasculitis [9]. No reports of coronary involvement in childhood were found in the literature.…”

Cogan and Behcet Syndromes

“…In cases with systemic vasculitis, vessel wall histology shows acute and chronic inflammation. [12][13][14] One case showed a dense mononuclear infiltrate, with multiple microabscesses. 12 There have been no reports of giant cells or granulomatous inflammation.…”