Coronary heart disease: the zinc/copper hypothesis

Klevay, Leslie M.

doi:10.1093/ajcn/28.7.764

Cited by 234 publications

(70 citation statements)

References 71 publications

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“…Following the suggestion that copper deficiency and a low ratio of serum copper to zinc may lead to increased mortality due to coronarv atherosclerosis ( 16). Allen and Klevav ( 11 studied plasma cholesterol concentrations in copper-defi&ent 'rats.…”

Section: Discussionmentioning

confidence: 99%

Studies of Lipids, Lipoproteins, and Apolipoproteins in Menkes' Disease

et al. 1984

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Section: Discussionmentioning

confidence: 99%

Studies of Lipids, Lipoproteins, and Apolipoproteins in Menkes' Disease

et al. 1984

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“…Excessive amount of Cu uptake gives rise to pain, irritation, anemia, diarrhea and organ damage (brain, kidney, liver etc. ), (Water Treatment Solutions (Cu), 1998;Adnan Iqbal et al, 2011;Mebrahtu and Zerabruk, 2011;Aenab et al, 2013) however, deficiency of copper causes arthrosis and cardiovasculer problems and, susceptibility to infection (Passwater, 1983;Klevay, 1975;Passwater, 1983;Campbell, 2001). A. nobilis, T. parthenium, S. bithynica and S. potentilla also contained significant amounts of Cu (1.84 ± 0.24 -13.06 ± 1.70).…”

Section: Determination Of Total Flavonoidsmentioning

confidence: 99%

In Vitro Screening of Natural Drug Potentials for Mass Production

Yaldız

Çalışkan

Aka

2017

Not Bot Horti Agrobo

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Methanolic extracts of 16 plant species, used in herbal and traditional medicinal preparations, collected from the same geographic region (Golcuk-Seben/Bolu, Turkey) were evaluated for their relative total phenolic contents, total antioxidant activities and their mineral contents in both dried plant samples and methanolic extracts. These species included Hypericum perforatum L., Thymus sipyleus Boiss., Equisetum arvense L., Achillea millefolium L., Tanacetum parthenium L., Thymus leucostomus Hausskn. & Velen., Usnea longissima, Herniaria incana Boiss., Teucrium polium L., Stachys bithynica Boiss., Anthemis nobilis L., Sambucus ebulus L., Berberis vulgaris L., Malus communis Desf., Matricaria chamomilla L. and Scorzonera laciniata L. Spectrophotometric Folin-Ciocalteu and DPPH free radical scavenging activity methods were performed to detect the total phenolic contents and total antioxidant activities of the methanolic extracts, respectively. The results show that the fruits of Berberis vulgaris L., have the highest antioxidant activity and aerial parts of Tanacetum parthenium L. have the highest total phenolics (92.62%). Mineral contents were determined by inductively coupled -mass spectrometry (ICP-MS). All dried plant samples and methanolic extracts contained high amounts of Si, Cu, Fe and Ca. The highest levels of Si, Cu, Fe and Ca were found in Equisetum arvense L., Anthemis nobilis L., and Thymus sipyleus Boiss. dried plant samples, whereas Se was only detected in Usnea longissima. The highest levels of Si, Cu, Fe and Ca were found in the methanolic extracts of Usnea longissima, Anthemis nobilis L. and Thymus sipyleus Boiss. respectively.

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“…Coronary heart disease (CHD) Disturbed Cu uptake has been proposed as a risk factor for coronary heart disease (Klevay, 1975;. HMG-CoAreductase is a key enzyme in endogenous cholesterol synthesis and its activity is increased in Cu deficiency (Yount et al, 1990).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Hohenheim Consensus Workshop: Copper

Schümann¹,

Classen

Dieter

et al. 2002

Eur J Clin Nutr

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Copper (Cu) is an essential trace element with many physiological functions. Homeostatic mechanisms exist to allow Cu to act as a cofactor in enzymatic processes and to prevent accumulation of Cu to toxic levels. The aim of this commentary is to better understand the role of dietary Cu supply in deficiency and under physiological and pathological conditions. The essentiality of Cu can be attributed to its role as a cofactor in a number of enzymes that are involved in the defence against oxidative stress. Cu, however, has a second face, that of a toxic compound as it is observed with accumulating evidence in hepatic, neurodegenerative and cardiovascular diseases. The destructive potential of Cu can be attributed to inherent physico-chemical properties.The main property is its ability to take part in Fenton-like reactions in which the highly reactive and extremely deleterious hydroxyl radical is formed. Diseases caused by dietary Cu overload could be based on a genetic predisposition. Thus, an assessment of risk-groups, such as infants with impaired mechanisms of Cu homeostasis regarding detoxification, is of special interest, as their Cu intake with resuspended formula milk may be very high. This implies the need for reliable diagnostic markers to determine the Cu status. These topics were introduced at the workshop by the participants followed by extensive group discussion. The consensus statements were agreed on by all members. One of the conclusions is that a re-assessment of published data is necessary and future research is required.

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Coronary heart disease: the zinc/copper hypothesis

Cited by 234 publications

References 71 publications

Studies of Lipids, Lipoproteins, and Apolipoproteins in Menkes' Disease

Studies of Lipids, Lipoproteins, and Apolipoproteins in Menkes' Disease

In Vitro Screening of Natural Drug Potentials for Mass Production

Hohenheim Consensus Workshop: Copper

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