Coronary heart disease risk factors and menopause: a study in 1684 French women

Trémollières, Florence; Pouillès, J. M.; Cauneille, Colette; Ribot, C.

doi:10.1016/s0021-9150(98)00252-4

Cited by 118 publications

(75 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…46 However, weight increase does not seem to be related to the menopause, as weight increase in women was similar whether they had gone through the menopause or not. 47 Tremollieres et al 48 found that about 30% of postmenopausal women had serum total cholesterol…”

Section: Resultsmentioning

confidence: 99%

Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA Project

et al. 2004

View full text Add to dashboard Cite

OBJECTIVE: To explore the relationship between hypercholesterolaemia, age and BMI among females and males. DESIGN: Population-based cross-sectional survey. SUBJECTS: The data came from the initial surveys of the WHO MONICA Project. In all, 27 populations with 48 283 subjects (24 017 males and 24 266 females) aged 25-64 y were used for the analysis. MEASUREMENTS: Total cholesterol, weight, height, BMI, prevalence of hypercholesterolaemia (PHC) defined as cholesterol Z6.5 mmol/l, and the prevalence of obesity (POB) defined as BMI Z30 kg/m 2 . RESULTS: PHC increased with age, with PHC in males being significantly higher than in females at age range 25-49 y and significantly lower than in females at age range 50-64 y. Age-related increase in hypercholesterolaemia was steeper in females than in males. There was a statistically significant positive association between hypercholesterolaemia and BMI. Multiple logistic regression analysis revealed a negative statistically significant (Po0.001) effect modification involving age and BMI on the risk of having hypercholesterolaemia both in females and males. The relation between PHC and BMI became weaker in higher age groups, with no statistically significant association in females aged 50-64 y. CONCLUSION: Public health measures should be directed at the prevention of obesity in young adults since the strongest effect of obesity on the risk of hypercholesterolaemia has been found in subjects aged 25-39 y.

show abstract

Section: Resultsmentioning

confidence: 99%

Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA Project

et al. 2004

View full text Add to dashboard Cite

show abstract

“…1,2 After menopause, the sharp increase in the prevalence of HTN to levels that equal or surpass that of men suggests that ovarian hormones participate in the protection afforded to premenopausal women. 1,[3][4][5][6][7] However, not all postmenopausal women develop HTN and CVD; therefore, identifying those women at risk is of critical importance.…”

mentioning

confidence: 99%

Surgical Menopause Increases Salt Sensitivity of Blood Pressure

et al. 2006

View full text Add to dashboard Cite

Abstract-Salt sensitivity of blood pressure is associated with an elevated risk of developing hypertension (HTN) and is an independent risk factor for cardiovascular disease. The prevalence of HTN increases after menopause. The aim of this study was to investigate prospectively whether the loss of ovarian hormones increases the occurrence of salt sensitivity among healthy premenopausal women. We enrolled 40 normotensive, nondiabetic women (age 47.2Ϯ3.5), undergoing hysterectomy-oophorectomy for nonneoplastic processes and not on hormone replacement, to determine the effect of changes in sodium intake on blood pressure the day before and subsequently 4 months after surgical menopause. Salt loading was achieved using a 2-L normal saline infusion and salt depletion produced by 40 mg of intravenous furosemide. A decrease Ͼ10 mm Hg in systolic blood pressure between salt loading and salt depletion was used to define salt sensitivity. Before and after menopause, salt-sensitive women exhibited higher waist/hip and waist/thigh ratios (PϽ0.01). Although all of the women remained normotensive, the prevalence of salt sensitivity was significantly higher after surgical menopause (21 women; 52.5%) than before (9 women; 22.5%; Pϭ0.01), because 12 (38.7%) salt-resistant women developed salt sensitivity after menopause. In summary, we demonstrated that the prevalence of salt sensitivity doubled as early as 4 months after surgical menopause, without an associated increase in blood pressure. Epidemiological studies indicate that development of HTN may not occur until 5 to 10 years after menopause. The loss of ovarian hormones may unmask a population of women prone to salt sensitivity who, with aging, would be at higher risk for the subsequent development of HTN and cardiovascular disease.

show abstract

“…Doenças cardiovasculares são a maior causa de morte em mulheres, e sua incidência é 4 vezes maior em mulheres pós-menopausadas do que em mulheres da mesma idade que estão na pré-menopausa 101 . A HA é o maior fator de risco para doença cardiovascular e, após ajuste para idade e índice de massa corpórea, as mulheres pós-menopausadas têm o dobro de chances de serem hipertensas quando comparadas às pré-menopausadas 102 . Dentre os mecanismos responsá-veis pelo aumento da PA após a menopausa destacam-se: 1) alteração na relação entre estrógenos e andrógenos, 2) aumento no estresse oxidativo e nível endógeno de endotelinas, 3) ativação do SRAA, 4) ganho de peso e 5) ativação do SNS 103 .…”

Section: -Dimorfismo Sexual E Ativação Sim-páticaunclassified

Mecanismos Fisiológicos E Fisiopatológicos Determinantes Da Atividade Vasomotora Simpática

Beutel¹,

Silva²,

Dugaich³

et al. 2006

Medicina (Ribeirão Preto)

View full text Add to dashboard Cite

RESUMO: A atividade vasomotora simpática é um dos determinantes da pressão arterial (PA). Estabelecer quais são os mecanismos geradores dessa atividade é importante para o entendimento de como o sistema cardiovascular opera, tanto em situações fisiológicas como fisiopatoló-gicas. Os principais grupos pré-motores do simpático estão confinados no núcleo paraventricular do hipotálamo (PVN) e região rostoventrolateral bulbar (RVLM). Em diversas situações fisiopatoló-gicas há aumento na atividade vasomotora simpática, em parte conseqüente a maior atividade dos neurônios do PVN e RVLM. Nesta breve revisão, foram discutidos os principais mecanismos de ativação simpática em diferentes modelos experimentais: 1) hipertensão renovascular, 2) hipertensão por baixa massa renal, 3) insuficiência cardíaca, 4) hipertensão por bloqueio do óxido nítrico, 5) obesidade e 6) dimorfismo sexual. As ações de diferentes mediadores sobre o PVN e RVLM podem em longo prazo determinar novos patamares de atividade simpática, modificando os níveis tensionais e dessa forma, contribuir para a progressão da doença cardiovascular. O sistema cardiovascular é o principal responsável pelo transporte de todas as substâncias necessárias ao bom funcionamento celular e a remoção dos produtos resultantes do metabolismo corporal. Para que isso se processe de forma adequada, a perfusão sanguínea tecidual e os níveis de pressão arterial (PA) precisam ser mantidos dentro de limites adequados. A ação integrada de diferentes sistemas de controle como, por exemplo, mecanismos neurais, hormonais, renais e locais é fundamental para a manutenção dos níveis ideais de PA e da perfusão tissular.Dentre os vários sistemas de controle cardiovascular, os mecanismos neurais e hormonais têm despertado a atenção de diferentes grupos de pesquisa. O melhor entendimento de como tais sistemas atuam tanto a curto como em longo-prazo é relevante no que

show abstract

Coronary heart disease risk factors and menopause: a study in 1684 French women

Cited by 118 publications

References 29 publications

Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA Project

Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA Project

Surgical Menopause Increases Salt Sensitivity of Blood Pressure

Mecanismos Fisiológicos E Fisiopatológicos Determinantes Da Atividade Vasomotora Simpática

Contact Info

Product

Resources

About