Coronary endothelial dysfunction in patients with early coronary artery disease is associated with the increase in intravascular lipid core plaque†

Choi, Byoung‐Joo; Prasad, Abhiram; Gulati, Rajiv; Best, Patricia J.M.; Lennon, Ryan J.; Barsness, Gregory W.; Lerman, Lilach O.; Lerman, Amir

doi:10.1093/eurheartj/eht132

Cited by 81 publications

(50 citation statements)

References 27 publications

(34 reference statements)

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“…In our earlier studies, we found that the protein-enriched fraction and the low molecular weight peptide extract of M. domestica maggot could inhibit atherosclerotic lesions (Chu et al, 2011(Chu et al, , 2013. Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease (Choi et al, 2013), and M' and M'-related inflammatory response are associated with endothelial dysfunction (Javeshghani et al, 2013;Rammos et al, 2013). In our previous studies, we found that early-activated THP-1 M' increased the proliferation and migration of ECV304 cells and their secretion of VEGF (Chu et al, 2013).…”

Section: Discussionmentioning

confidence: 93%

Effect ofMusca domesticmaggot polypeptide extract on HUVEC dysfunction induced by early-activated macrophages

Chu

Jin

et al. 2015

Pharmaceutical Biology

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Context: Musca domestica Linn. maggot is a traditional Chinese medicine. In our previous studies, Musca domestica maggot protein-enriched fraction and polypeptide extract (molecular weight 530 kD) were found to reverse endothelial cell dysfunction in atherosclerotic lesions. Objective: This study determines whether and how M. domestica maggot polypeptide extract affects the dysfunction of human umbilical vein endothelial cells (HUVEC) induced by macrophages (M'). Materials and methods: HUVEC and early-activated THP-1 M' (incubated with LPS of 1 mg/ml for 2 h) were co-cultured in a Transwell system. The effects of Musca domestica maggot polypeptide extract (with increasing concentrations, i.e., 1.0, 2.5, 5.0, 10.0, 20.0, and 40.0 mg/ml) on the proliferation and migration HUVEC and their secretion of vascular endothelial growth factor (VEGF) were determined by flow cytometry, modified Boyden chamber assay, and enzyme-linked immunosorbent assay (ELISA) after incubation for 24 h. Results: Musca domestica maggot polypeptide extract decreased the proliferation of HUVEC in a concentration-dependent manner, with a 50% effective concentration (EC 50 ) of 22.16 ± 1.48 mg/ml, and effectively inhibited HUVEC migration (EC 50 ¼ 35.15 ± 2.03 mg/ml) and VEGF secretion (EC 50 ¼ 28.64 ± 1.29 mg/ml). Discussion and conclusion: Musca domestica maggot polypeptide extract can inhibit the dysfunction of HUVEC induced by early-activated THP-1 M'.

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Section: Discussionmentioning

confidence: 93%

Effect ofMusca domesticmaggot polypeptide extract on HUVEC dysfunction induced by early-activated macrophages

Chu

Jin

et al. 2015

Pharmaceutical Biology

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“…As noted above, the reduced potency due to endothelial damage of the peripheral artery or the coronary artery was implicated to cause the high sensitivity of RR to VAP 13 14 . There are various papers on such disease conditions caused by dysfunction of the myocardial microcirculation, including Syndrome X 15 , arteriosclerosis 16 , diabetic hypertension 17 , and hyperthyroidism 18 . In this study the rate of occurrence between the history of heart failure and the manifestation of RR was significantly correlated.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Reverse Redistribution Phenomenon for <sup>201</sup>Tl Scintigraphy in Nonischemic Disease

Suyama

Shinozuka

Sasamori

et al. 2014

Showa Univ J Med Sci

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: The reverse redistribution phenomenon RR on 201 Tl SPECT has been focused mainly on ischemic improvement regions after reperfusion therapy or vasospastic angina pectoris. However, RR analysis has not been used in the context of non-ischemic disease. The aim of this study was to evaluate the clinical role of RR on 201 Tl SPECT in patients without a history of myocardial ischemia. We retrospectively enrolled 86 patients showing RR by myocardial perfusion SPECT and studied 75 other patients as a control group. For quantitative analysis, each 201 Tl SPECT polar map was divided into 13 segments. Differences between the RR and control group were assessed with respect to patient characteristics and cardiac event-free survival using the Kaplan-Meier method. RR was detected frequently in the inferoposterior wall, septal portion of the anterior wall, and septum. The two groups showed signi cant differences in rates of heart failure P 0.01 , hypertrophic cardiomyopathy P 0.05 , and wall motion abnormality P 0.05 , but not in the rate of event occurrence. The study demonstrated that RR on 201 Tl SPECT could indicate the existence of myocardial damage ; however, it would not be a factor that determines the prognosis.

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“…In particular, a high thrombus burden, as well as the presence of a lipid rich plaque and plaque erosion are associated with the occurrence of distal embolization. 16 Finally, another component of CMVO is represented by the individual susceptibility to microvascular dysfunction, maybe related to the function, as well as to the structure and the density of the microcirculation. 17 Genetic factors, like 1976T.C polymorphism of the adenosine 2A receptors gene, may modulate adenosine-induced vasodilation.…”

Section: Mechanisms Of Coronary Microvascular Obstructionmentioning

confidence: 99%

Pathophysiological aspects and management workflow of coronary microvascular obstruction in ST-segment elevation myocardial infarction

2016

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Restoring blood flow to ischemic but viable myocardium and reducing infarct size constitute the goals of reperfusion therapy with fibrinolytic drugs or primary percutaneous intervention in patients with ST-segment elevation myocardial infarction (STEMI). However, in a sizable proportion of patients, this intervention gains to reopen the obstructed epicardial coronary artery but does not achieve myocardial reperfusion because of coronary microvascular obstruction phenomenon (CMVO). In the last years, consistent evidence has pointed out how CMVO has a negative impact on outcome in patients with acute STEMI. Of note, most of the trials in this setting, mainly targeting reperfusion damage, have failed to show beneficial effects. In this article we provide a revision of mechanisms, diagnosis and prognosis of CMVO in acute STEMI, also pointing out the need of an integrated approach in order to prevent and treat CMVO in the different time windows of the acute event.

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Coronary endothelial dysfunction in patients with early coronary artery disease is associated with the increase in intravascular lipid core plaque†

Cited by 81 publications

References 27 publications

Effect ofMusca domesticmaggot polypeptide extract on HUVEC dysfunction induced by early-activated macrophages

Effect ofMusca domesticmaggot polypeptide extract on HUVEC dysfunction induced by early-activated macrophages

Clinical Significance of Reverse Redistribution Phenomenon for <sup>201</sup>Tl Scintigraphy in Nonischemic Disease

Pathophysiological aspects and management workflow of coronary microvascular obstruction in ST-segment elevation myocardial infarction

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