Coronary Disease the Harveian Oration of 1946

Cassidy, Maurice

doi:10.1016/s0140-6736(46)91053-7

Cited by 32 publications

(3 citation statements)

References 18 publications

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“…The epidemic of CHD in the UK started among SCs 1 and 2 in the 1930s 35. This period followed the 1920s, when maids and servants became expensive and difficult to get.…”

Section: Discussionmentioning

confidence: 99%

The effect of improving the thermal quality of cold housing on blood pressure and general health: a research note

Lloyd¹,

McCormack²,

McKeever³

et al. 2008

Journal of Epidemiology & Community Health

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“…The epidemic of CHD in the UK started among SCs 1 and 2 in the 1930s 35. This period followed the 1920s, when maids and servants became expensive and difficult to get.…”

Section: Discussionmentioning

confidence: 99%

The effect of improving the thermal quality of cold housing on blood pressure and general health: a research note

Lloyd¹,

McCormack²,

McKeever³

et al. 2008

Journal of Epidemiology & Community Health

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“…Unfortunately, there are currently few (if any) robust therapeutic options to lower cardiovascular risk for post-menopausal women – and to a large degree, this reflects the lack of enrollment and study of women in cardiovascular prevention trials. While this neglectful inattention to the plight of coronary artery disease in women has a history that spans decades [21], even the most important cardiovascular trials reported in 2017 have woefully low percentages of women enrolled in them (e.g., 16–26%) [22].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic salpingo-oophorectomy & surgical menopause for inherited risks of cancer: the need to identify biomarkers to assess the theoretical risk of premature coronary artery disease

Batulan

Maarouf

Shrivastava

et al. 2018

womens midlife health

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BackgroundSome women with genetic risk of breast and/or ovarian cancer (e.g., BRCA1/2) opt to undergo prophylactic salpingo-oophorectomy (PSO, or surgical removal of the ovaries & fallopian tubes) in order to reduce their risk of cancer. As a consequence, these women experience “surgical menopause” – accompanied by more severe climacteric symptoms that occur in a much shorter time frame. While the risk of coronary artery disease (CAD) rises with menopause, little is known about how the sudden loss of ovarian function from PSO alters the whole-body physiology, and whether it predisposes women to premature CAD.Methods/DesignTo manage CAD risk there is a prerequisite for reliable biomarkers that can help guide risk assessment and therapeutic interventions. To address these needs, this prospective, observational cohort study will evaluate surrogate markers reflective of CAD health in women experiencing surgical menopause after PSO. Twenty women representing each of the following groups will be enrolled over 3 years (total participants = 240): (i) pre-menopausal PSO, (ii) post-menopausal PSO, (iii) pre-menopausal women undergoing other pelvic surgery, and (iv) pre-menopausal controls (no surgery). All participants will provide blood plasma samples pre- and 1, 3, 6, & 12 months post-operatively, with serial samples collectively assessed for measurements of the study’s primary endpoints of interest. These include a hormone profile (estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), and progesterone) and both conventional (lipid profile) and novel biomarkers (Heat Shock Protein 27 (HSP27), HSP27-antibodies (HSP27 Ab), proprotein convertase subtilisin/kexin 9 (PCSK9), inflammatory cytokines) of CAD. Another aspect of this study is the measurement and analysis of retinal vessel diameters – an emerging physiological parameter reflective of CAD risk. Finally, a patient engagement exercise will result in the drafting of patient-generated questionnaires that address the well-being and health concerns of these women as they transition through premature menopause and work with our research team to identify and discuss their health priorities.DiscussionThe protocol of our planned study investigating the effects of PSO on CAD is described herein. Characterization of novel CAD markers in women experiencing surgical menopause will yield new insights into the role of the functional ovary in modulating lipid parameters and other CAD risk factors such as HSP27 and HSP27 Ab.

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“…in 1930 the death rate in England from coronary artery disease was 148 per million persons living, by 1939 this figure had risen to 473 (Cassidy, 1946). According to the Registrar‐General's returns deaths ascribed to coronary artery disease numbered 61,429 in 1952 as compared with 25,012 in 1945.…”

mentioning

confidence: 99%

Electrocardiography—6

Gibson

1954

Int J Clinical Practice

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Coronary Disease the Harveian Oration of 1946

Cited by 32 publications

References 18 publications

The effect of improving the thermal quality of cold housing on blood pressure and general health: a research note

The effect of improving the thermal quality of cold housing on blood pressure and general health: a research note

Prophylactic salpingo-oophorectomy & surgical menopause for inherited risks of cancer: the need to identify biomarkers to assess the theoretical risk of premature coronary artery disease

Electrocardiography—6

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