Coronary Disease Among United States Soldiers Killed in Action in Korea

Enos, William F.; Holmes, Robert H.; Beyer, James C.

doi:10.1001/jama.1986.03380200097028

Cited by 151 publications

(159 citation statements)

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“…Again, histology was not possible in that study. In fact, coronary artery plaques have been shown to be present at an early age, 26 and even angiographically normal vessels may have early atheromatous lesions in young adults. 27 The present investigation used a novel monkey model of aging, 8 phylogenetically closer to humans but devoid of complications secondary to associated cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys

Asai

Kudej

Shen

et al. 2000

ATVB

177

125

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Abstract-To determine the effects of aging on vasoactivity in a primate model (Macaca fascicularis), 13 young male monkeys (aged 7.1Ϯ0.4 years) and 9 old male monkeys (aged 19.8Ϯ0.6 years) were chronically instrumented for measurement of left ventricular and aortic pressures and cardiac output. Total cholesterol, triglyceride, and fasting blood sugar levels were not different between the 2 groups. There were no significant differences in baseline mean aortic pressure and total peripheral resistance (TPR) in the young monkeys versus the old monkeys. TPR fell less (PϽ0.05) with acetylcholine (1 g/kg) in old monkeys (Ϫ25Ϯ1%) than in young monkeys (Ϫ34Ϯ2%), whereas decreases in TPR with sodium nitroprusside were similar in old and young monkeys. There was no evidence of atherosclerosis, but apoptosis of endothelial cells was enhanced (PϽ0.05) in the aortas and femoral arteries, but not in the media, of the old monkeys. There was a relationship (rϭ0.62, Pϭ0.013) between the incidence of terminal deoxynucleotidyl transferasemediated dUTP nick end-labeling (TUNEL)-positive endothelial cells and endothelial cell density in the femoral artery. The reduced endothelial cell density was also correlated (rϭ0.82, PϽ0.01) with depressed TPR responses to acetylcholine. Thus, vascular endothelial dysfunction was present in old monkeys without evidence of atherosclerosis, which may be due to endothelial apoptosis and reduced endothelial cell density. (Arterioscler Thromb Vasc Biol.

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Section: Discussionmentioning

confidence: 99%

Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys

Asai

Kudej

Shen

et al. 2000

ATVB

177

125

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“…Tau pathology seen in children and young adults, if confirmed, could modify our view on AD as deeply as the unexpected finding that young soldiers, killed in action in Korea, had signs of coronary atherosclerosis [6]: AD might not be a disease of the aged, but, as atheroma, a life-long disorder.…”

mentioning

confidence: 94%

Tau pathology in children and young adults: can you still be unconditionally baptist?

Duyckaerts

2011

Acta Neuropathol

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“…Studies of the coronary arteries of US service men killed during the Korean and Vietnam wars found that 77 and 45%, respectively, of the men had evidence of atherosclerosis. 4,5 Other studies, such as the Bogalusa Heart Study, have reported that fatty streaks and even atheromatous plaques are present in young children. 6 Professor David Barker and his co-workers in Southampton have shown that low birth weight is positively associated with subsequent hypertension and cardiovascular mortality.…”

Section: Introductionmentioning

confidence: 99%

Maternal age in pregnancy and offspring blood pressure in childhood in the Avon Longitudinal Study of Parents and Children (ALSPAC)

et al. 2005

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Associations between maternal age in pregnancy and offspring blood pressure (BP) at age 7 1 2 were investigated in 7623 singletons from the Avon Longitudinal Study of Parents and Children (ALSPAC). In models adjusted for age and sex there was an inverse relationship between maternal age and BP in children: b ¼ À0.06 mmHg per year of maternal age (95% CI À0.10 to À0.01, P ¼ 0.02) for systolic BP and b ¼ À0.04 (95% CI À0.07 to À0.01, P ¼ 0.02) for diastolic BP.However, this association disappeared after adjustment for confounding factors: b ¼ À0.02 mmHg per year of maternal age (95% CI À0.07 to 0.04, P ¼ 0.5) for systolic BP and b ¼ À0.03 (95% CI À0.07 to 0.01, P ¼ 0.2) for diastolic BP. We conclude that there is no evidence of a relationship between maternal age in pregnancy and childhood BP in this contemporary birth cohort.

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Coronary Disease Among United States Soldiers Killed in Action in Korea

Cited by 151 publications

References 0 publications

Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys

Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys

Tau pathology in children and young adults: can you still be unconditionally baptist?

Maternal age in pregnancy and offspring blood pressure in childhood in the Avon Longitudinal Study of Parents and Children (ALSPAC)

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