Coronary Atherosclerosis and Malignancies in Diabetic Patients

Lee, Joseph C.; Lyall, David; Wee, Y.

doi:10.1159/000519287

Cited by 1 publication

(1 citation statement)

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“…Metaanalysis is a research method that systematically analyzes and quantitatively synthesizes the results of multiple independent studies with the same research purpose [34]. The purpose is to improve the statistical test efficiency, evaluate the inconsistencies or contradictions of research results, find the shortcomings of a single study, and process a large number of literatures, which is not limited by the number of studies [35][36][37]. It plays an important role in clinical diagnosis, treatment, risk assessment, preventive intervention, health service, and decision-making.…”

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confidence: 99%

Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis

Chen

Zou

Wang

2022

Computational and Mathematical Methods in Medicine

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Objective. Obstructive sleep apnea syndrome (OSA) is the most common type of sleep disorders. This study aimed to systematically review the correlation between OSA and the risk of coronary atherosclerosis. Methods. Literature on case-control studies on the relationship between coronary heart disease (CHD) and sleep apnea syndrome was collected and collated, and the incidence of SAS in CHD and non-CHD patients was observed and compared. RevMan 5.2 analysis software and Stata12SE analysis software were used for heterogeneity test and combination analysis of the included studies. The results were expressed with odds ratio (OR), 95% confidence intervals (CI) were calculated, and publication bias and sensitivity tests were evaluated. Results. There was a statistical difference in OSA associated with the risk of coronary atherosclerosis between the experimental group and the control group [ OR = 1.38 , 95% CI (1.18, 1.62), P < 0.0001 , I 2 = 0 % , Z = 3.93 ]. OSA associated with vascular endothelial injury [ OR = 3.59 , 95% CI (3.00, 4.29), P < 0.00001 , I 2 = 90 % , Z = 14.09 ]. OSA is associated with vascular oxidation emergency [ OR = 2.19 , 95% CI (2.05, 2.33), P < 0.00001 , I 2 = 94 % , Z = 23.40 ]; OSA is associated with chronic vascular inflammation [ OR = 1.70 , 95% CI (1.39, 2.07), P < 0.00001 , I 2 = 16 % , Z = 5.18 ]. Conclusion. The incidence of obstructive sleep apnea in patients with CHD was higher than that in non-CHD patients, and obstructive sleep apnea was a risk factor for CHD.

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