Coronary artery disease in women: different, often undertreated.

Jneid, Hani; Thacker, Holly L.

doi:10.3949/ccjm.68.5.441

Cited by 33 publications

(19 citation statements)

References 53 publications

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“…1 Moreover, there is an accumulating body of evidence that not only women are understudied in clinical trials; they are also underdiagnosed due to different symptoms upon presentation, and even under-treated on admission. [2][3][4][5][6][7] Underrepresentation of women was particularly stressed in the American Heart Association (AHA) prevention guidelines of CVD in women published in 2007. 8 These guidelines were based on a mere population of 30% women enrolled in the clinical trials, albeit they exhibit a similar prevalence of coronary artery disease (CAD) as men.…”

Section: Introductionmentioning

confidence: 99%

Gender disparities in acute coronary syndrome

Ghadri

Sarcon

Jaguszewski

et al. 2015

Journal of Cardiovascular Medicine

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Section: Introductionmentioning

confidence: 99%

Gender disparities in acute coronary syndrome

Ghadri

Sarcon

Jaguszewski

et al. 2015

Journal of Cardiovascular Medicine

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“…[52][53][54] This early consideration of CHD and evaluation of risk factors often occurs in a primary care setting weeks, months, or even years before a woman is seen by a cardiologist or before the first invasive cardiac testing is contemplated. [55][56][57][58][59] Little is known about this primary care process, including the timing of the first diagnosis of CHD or evaluation of CHD risk factors prior to cardiac events. This study addresses the recognition and treatment of CHD and CHD risk factors in the period prior to an incident myocardial infarction (MI).…”

Section: Introductionmentioning

confidence: 99%

Identification of Women's Coronary Heart Disease and Risk Factors Prior to First Myocardial Infarction

Yawn

Wollan

Jacobsen

et al. 2004

Journal of Women's Health

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“…Furthermore, since 1980, death from CHD has declined dramatically in men in the western world but has increased in women. 1 With the recent recognition of this problem, considerable interest has been focused on the study of sex based differences in the outcome of patients with acute myocardial infarction (AMI) in the western world. Several studies have compared the outcome of women and men with AMI, with conflicting data.…”

mentioning

confidence: 99%

Mortality caused by acute myocardial infarction in Qatari women

Suwaidi

2004

Heart

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T he long held belief that coronary heart disease (CHD) in women has a more benign prognosis than in men has resulted in less aggressive diagnosis and management patterns. Contrary to this belief, CHD is the leading cause of death in white women aged 60 years or older in the USA and outnumbers the next 16 causes of death in women combined, including cancers. Furthermore, since 1980, death from CHD has declined dramatically in men in the western world but has increased in women. 1With the recent recognition of this problem, considerable interest has been focused on the study of sex based differences in the outcome of patients with acute myocardial infarction (AMI) in the western world. Several studies have compared the outcome of women and men with AMI, with conflicting data.2-5 The majority of these studies have been performed in western populations and so may not necessarily apply to other ethnic groups such as the Middle Eastern population. The aim of the present study was to determine the clinical characteristics and in-hospital mortality from AMI in Qatari women. METHODSThis study was based at Hamad General Hospital, Doha, Qatar, which is the only tertiary care centre in the country and so all patients with AMI are treated here. The Hamad General Hospital cardiology database was used for this study; this database comprises data collected from all patients admitted to the cardiology department at the hospital since January 1991. Data were collected from the clinical records by the patients' physicians at the time of the patients' hospital discharge according to predefined criteria for each data point. We focused our study only on Qatari patients because it is a stable population and avoids the bias in the fluctuation of the expatriate population in the country. The study was approved by the institution review board.With the described database, all patients presenting with AMI in the period between 1991 and 2001 were identified. Age, sex, risk factors including smoking, hypertension, hypercholesterolaemia, diabetes, pre-existing coronary heart disease, in-hospital mortality and morbidity, as well as acute medical care provided were analysed. Data are expressed as mean (SD). Student's t test was employed for comparison between the mean values of the two groups and x 2 analysis was performed to test for differences in proportions of categorical variables between two or more groups. Multivariate stepwise regression analysis was used to identify predictors of outcome. A probability value of p , 0.05 was considered significant. RESULTSDuring the 10 year period a total of 20 856 patients were admitted to the coronary care unit and cardiology wards. Of these, 1598 Qatari patients were admitted with AMI; 1147 were male and 451 were female. When compared to men, women were older (62.1 (11.5) years v 59.9 (12.6) years, p , 0.001) and were more likely to have diabetes (68.5% v 48.3%, p , 0.001), hypertension (54.8% v 30.9%, p , 0.001), and hyperlipidaemia (30.4% v 24.9%, p = 0.029), but were less likely to be smokers (0....

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Coronary artery disease in women: different, often undertreated.

Cited by 33 publications

References 53 publications

Gender disparities in acute coronary syndrome

Gender disparities in acute coronary syndrome

Identification of Women's Coronary Heart Disease and Risk Factors Prior to First Myocardial Infarction

Mortality caused by acute myocardial infarction in Qatari women

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