when it comes to pain. Pain research has moved beyond debating whether sex differences in pain exist to recognizing the importance of these differences in managing pain. 1,2 Before this discussion can progress, however, the use of certain terminology must be clarified. Sex-based differences refer to biological features, whereas gender-related differences reflect socially derived characteristics. Although biological sex exerts a major influence on gender identity, sex and gender are not interchangeable. Thus, when anatomical features, such as chromosomes and reproductive features, are at issue, it is a matter of sex-based differences. When measures of masculinity or femininity are referenced, gender is the accurate focus of any comparisons. That said, differences in both sex and gender affect the differences in pain experiences, which is the focus of this discussion.As far back as 1998, the National Institutes of Health (NIH) convened a panel on Pain and Gender. The conclusion, based on available data, was that women experience more pain and discuss pain more frequently than men and require different pain treatments for optimum relief. Pain management, it turns out, is not a one dose fits all program. From the ensuing research, we have learned that women experience pain symptoms during a heart attack differently from men but do not seek prompt treatment. 3 Even when they do, the intervention is often less aggressive, and it may be reflected in lower rates of survival. 4,5 For example:• 44% of women who have heart attacks die within 1 year compared with 27% of men, • 35% of female and 18% of male heart attack survivors will have another heart attack within 6 years. • 46% of female and 22% of male heart attack survivors will be disabledIn 2006, members of the Sex, Gender and Pain Special Interest Group of the International Association for the Study of Pain launched the program "Real Women, Real Pain" to draw attention to the significant impact of chronic pain in women and the lack of attention to this widespread problem. 1 A report by the National Center for Health Statistics (NCHS) shows that as the U.S. population ages, complaints of pain and use of painkillers are rising, particularly among white women older than 45. 6 Although sex-based biology and gender may not account for all the differences in the pain response, research suggests that genetic, anatomical, and functional differences in the brain could have implications for better diagnosis and treatment in women who suffer from chronic pain. 7What is the practical significance or clinical relevance of sex-related differences in pain?Considerable evidence, amassed since the 1990s, suggests that women experience pain differently from men, and sexrelated influences on pain responses are validated. In fact, the significantly higher prevalence of chronic pain disorders in women, such as temporomandibular disorders, fibromyalgia, migraine headaches, and irritable bowel syndrome, mandates attention to chronic pain in women as a necessity for all practitioners. In ad...