Coronary artery disease and hypertension in a non-selected spinal cord injury patient population

Aidinoff, Elena; Bluvshtein, Vadim; Bierman, Uri; Gelernter, Ilana; Front, Lilach; Catz, Amiram

doi:10.1038/sc.2016.109

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…17 Patients whose blood pressure values were greater than or equal to 140/90 mmHg or those who were taking antihypertensive medication according to their medical records were classified as hypertensive. 18 Persons who smoked or used smokeless tobacco daily until within 1 year of the interview were considered current daily smokers and daily tobacco users. Never smokers were those who responded with "occasionally" or "not at all" on the questionnaire, and ex-smokers were those who smoked daily prior to 1 year of interview.…”

Section: Data Collectionmentioning

confidence: 99%

Association of smoking with coronary artery disease in Nepalese populations: a case control study

Basnet

Mallah

et al. 2019

Toxicology Research

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There are well-known traditional risk factors for coronary artery disease (CAD). Among them, smoking is one of the most prominent and modifiable risk factors. This study aims to determine the magnitude of smoking as a risk factor for CAD in the Nepalese population. A hospital-based age- and sex-matched case–control study was carried out with a total of 612 respondents. Bivariate analysis showed that the risk of developing CAD in ex-smokers and current smokers was higher (odds ratio (OR): 1.81 (confidence interval (CI): 1.21–2.7) and OR: 5.2 (CI: 3.4–7.97)), with p-values less than 0.004 and <0.00001, respectively, compared to the risk in never smokers. From stratified socio-demographic, cardio-metabolic, behavioural and psychosocial risk factor analysis, smoking was found to be associated with CAD in almost all subgroups. In the subsequent multivariate analysis, adjustment for socio-demographic, cardio-metabolic and psychosocial risk factors showed a steady increase in risk. However, further adjustment for behavioural risk factors (alcohol use and physical activity) showed that the risk was attenuated by 59% in current smokers. After adjusting for the covariates, current smokers and ex-smokers had an increased risk of CAD (OR: 6.64, 95% CI: 3.64–12.12, p < 0.00001; OR: 1.89, 95% CI: 1.08–3.31, p < 0.012, respectively) compared with non-smokers. In conclusion, smoking was found to increase the risk of CAD in the Nepalese population.

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Section: Data Collectionmentioning

confidence: 99%

Association of smoking with coronary artery disease in Nepalese populations: a case control study

Basnet

Mallah

et al. 2019

Toxicology Research

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“…During treatment, multiple system complications could occur, including respiratory failure, pneumonia, bedsores, urinary tract infection (UTI), thromboembolic diseases, and cardiovascular accidents (Maharaj et al, 2016). The incidence of coronary atherosclerotic heart disease (CHD) caused by abnormal lipid metabolism after SCI is as high as 12%, which is significantly higher than that of the general population (6%) (Aidinoff et al, 2017). Current serum lipid analysis shows that TC, LDL-c, VLDL-p, LDL-c, and TG are elevated, while HDL-c is reduced in patients with SCI (Koyuncu et al, 2017;La Fountaine et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of the Proteome in Exosomes Derived From Plasma: Exosomes Involved in Cholesterol Metabolism Process of Patients With Spinal Cord Injury in the Acute Phase

et al. 2021

Front. Neuroinform.

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Spinal cord injury (SCI) is a common but severe disease caused by traffic accidents. Coronary atherosclerotic heart disease (CHD) caused by dyslipidemia is known as the leading cause of death in patients with SCI. However, the quantitative analysis showed that the cholesterol and lipoprotein concentrations in peripheral blood (PB) did not change significantly within 48 h after SCI. Due to the presence of the Blood spinal cord barrier (BSCB), there are only few studies concerning the plasma cholesterol metabolism in the acute phase of SCI. Exosomes have a smaller particle size, which enables them relatively less limitation of BSCB. This study uses exosomes derived from the plasma of 43 patients in the acute phase of SCI and 71 patients in the control group as samples. MS proteomics and bioinformatics analysis found 590 quantifiable proteins, in which 75 proteins were upregulated and 153 proteins were downregulated, and the top 10 differentially expressed proteins are those including downregulating proteins: HIST1H4A, HIST2H3A, HIST2H2BE, HCLS1, S100A9, HIST1H2BM, S100A8, CALM3, YWHAH, and SFN, and upregulating proteins: SERPIND1, C1QB, SPTLC3, IGHV4-28, C4A, IGHV4-38-2, IGHV4-30-2, SLC15A1, C4B, and ACTG2. Enrichment analysis showed that the largest part of proteins was related to cholesterol metabolism among the downregulated proteins. The main components of cholesterol [ApoB-48 and ApoB-100 increased, ApoA-I, ApoA-II, ApoA-IV, ApoC, ApoE, and Apo(a) decreased] were changed in exosomes derived from plasma of patients. ELISA analysis showed that some components were disordered in the acute phase of SCI. These results suggested that the exosomes might be involved in cholesterol metabolism regulation in the acute phase of SCI.

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“…The following year, La Fountaine et al [ 101 ] identified that a lower triglyceride cutoff value was associated with dyslipidemia in people with SCI (115 mg/dL in SCI above T4 and 137 mg/dL in SCI below T5) than in people without SCI. Similarly, in another study, people with injuries below T6 had a higher rate of hypercholesterolemia than people with SCI above T7 [ 102 ]. These studies suggest that male gender and level of injury are unmodifiable cardiovascular risk factors ( Figure 1 ), and standard cutoffs for hypertriglyceridemia may be inappropriate for SCI.…”

Section: Dyslipidemia After Scimentioning

confidence: 92%

The Diagnosis and Management of Cardiometabolic Risk and Cardiometabolic Syndrome after Spinal Cord Injury

Farkas

Burton

McMillan

et al. 2022

JPM

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Individuals with spinal cord injuries (SCI) commonly present with component risk factors for cardiometabolic risk and combined risk factors for cardiometabolic syndrome (CMS). These primary risk factors include obesity, dyslipidemia, dysglycemia/insulin resistance, and hypertension. Commonly referred to as “silent killers”, cardiometabolic risk and CMS increase the threat of cardiovascular disease, a leading cause of death after SCI. This narrative review will examine current data and the etiopathogenesis of cardiometabolic risk, CMS, and cardiovascular disease associated with SCI, focusing on pivotal research on cardiometabolic sequelae from the last five years. The review will also provide current diagnosis and surveillance criteria for cardiometabolic disorders after SCI, a novel obesity classification system based on percent total body fat, and lifestyle management strategies to improve cardiometabolic health.

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Coronary artery disease and hypertension in a non-selected spinal cord injury patient population

Cited by 11 publications

References 19 publications

Association of smoking with coronary artery disease in Nepalese populations: a case control study

Association of smoking with coronary artery disease in Nepalese populations: a case control study

Bioinformatic Analysis of the Proteome in Exosomes Derived From Plasma: Exosomes Involved in Cholesterol Metabolism Process of Patients With Spinal Cord Injury in the Acute Phase

The Diagnosis and Management of Cardiometabolic Risk and Cardiometabolic Syndrome after Spinal Cord Injury

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