Coronary Artery Calcium Scoring: New Insights into Clinical Interpretation—Lessons from the CAC Consortium

Adelhoefer, Siegfried; Uddin, S.M. Iftekhar; Osei, Albert D.; Obisesan, Olufunmilayo H.; Blaha, Michael; Dzaye, Omar

doi:10.1148/ryct.2020200281

Cited by 49 publications

(25 citation statements)

References 47 publications

(63 reference statements)

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“…In the CAC Consortium study, in 6375 patients with “SPRINT-like” characteristics (age > 50 years and Framingham risk score > 15%), it was shown that CAC stratifies hypertension and recategorizes the 10-year risk probability of cardiovascular events [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

et al. 2021

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“…The scores of 0, 1 to 100, 101 to 400, greater than 400 represented as stage normal, mild, moderate, and severe CAD risk. This re-classification could provide a reliable predictor for long-term all-cause mortality and cardiovascular mortality [ 18 ]. Even though the cost and radiation exposure of cardiac MDCT are concerns, CAC still has the ability to detect asymptomatic atherosclerosis at an early stage [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Association between the Severity of Nonalcoholic Fatty Liver Disease and the Risk of Coronary Artery Calcification

et al. 2021

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Background and Objectives: There are limited data on the association between severity of non-alcoholic fatty liver disease (NAFLD) and coronary artery calcification. This study investigated sonographic diagnosed NAFLD and coronary artery calcium score (CAC) as detected by cardiac multidetector computed tomography in general populations. Materials and Methods: A total of 545 patients were enrolled in this study. NAFLD was diagnosed by ultrasonography examination and CAC score were evaluated by cardiac multidetector computed tomography. The association between NAFLD and artery calcium score stage was determined by logistic regression analysis and Spearman correlation coefficient analysis. Results: Of all the participants, 437 (80.2%) had ultrasonography-diagnosed NAFLD and 242 (44%) had coronary artery calcification (CAC > 0). After adjustment for cardiovascular risk factors, the risk of developing coronary artery calcification was 1.36-fold greater in the patients with different severity of NAFLD compared to those without NAFLD (OR = 1.36, 95% CI = 1.07–1.77, p = 0.016). The highest OR for separate coronary artery calcification was 1.98 (OR = 1.98, 95% CI = 1.37–2.87, p < 0.001) in the left main artery, and the risk was still 1.71-fold greater after adjustments (OR = 1.71, 95% CI = 1.16–2.54, p = 0.007). Conclusions: This cross-sectional study demonstrated that the severity of NAFLD was associated with the presence of significant coronary artery calcification, especially in the left main coronary artery, suggesting increasing the cardiovascular risk.

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“…13 Finally, the coronary calcium Consortium has assembled a database of 66,636 asymptomatic adult participants free cardiovascular disease at baseline. 14 It is a multicenter, retrospective, cohort study, designed to study the association between coronary calcium and long-term, cause-specific mortality.…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Calcium: Where Do We Stand After Over 3 Decades?

Grundy

Stone

2021

The American Journal of Medicine

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Coronary Artery Calcium Scoring: New Insights into Clinical Interpretation—Lessons from the CAC Consortium

Cited by 49 publications

References 47 publications

Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

Association between the Severity of Nonalcoholic Fatty Liver Disease and the Risk of Coronary Artery Calcification

Coronary Artery Calcium: Where Do We Stand After Over 3 Decades?

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