Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

Cereda, Alberto; Toselli, Marco; Palmisano, Anna; Vignale, Davide; Khokhar, Arif; Campo, Gianluca; Bertini, Matteo; Loffi, Marco; Andreini, Daniele; Pontone, Gianluca; Patelli, Gianluigi; Sangiorgi, Giuseppe; Tumminello, Gabriele; Elia, Mariarosa; Iacovoni, Attilio; Carugo, Stefano; Rapezzi, Claudio; Colombo, Antonio; Giannini, Francesco; Esposito, Antonio

doi:10.1038/s41440-021-00798-9

Cited by 19 publications

(25 citation statements)

References 23 publications

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“…Another possible explanation is that the free-floating spike proteins may interact with angiotensin-converting enzyme 2. The imbalance between angiotensin II (overactivity) and angiotensin (deficiency) might play a role in the genesis of acute elevation in blood pressure, and this could be applied as a result of vaccination [61] .…”

Section: Resultsmentioning

confidence: 99%

Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis

Ahmed

Mohamed

Essa

et al. 2022

IJC Heart & Vasculature

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Section: Resultsmentioning

confidence: 99%

Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis

Ahmed

Mohamed

Essa

et al. 2022

IJC Heart & Vasculature

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Section: Discussionmentioning

confidence: 99%

“…The imbalance between angiotensin II (overactivity) and angiotensin (deficiency) might play a role in the genesis of acute elevation in blood pressure, and this could be applied as a result of vaccination [62].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: a systematic review and meta-analysis

Ahmed¹,

Mohamed

Essa³

et al. 2022

Preprint

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Background and aimsConcerns have been raised recently about takotsubo cardiomyopathy after receiving COVID-19 vaccines, particularly the messenger RNA (mRNA) vaccines. The goal of this study was to compile case reports in order to provide a comprehensive overview of takotsubo cardiomyopathy associated with COVID-19 vaccines.MethodsFrom inception until March 10, 2022, a systematic literature search was conducted in PubMed and Google Scholar. The study included individuals who developed cardiac takotsubo cardiomyopathy as a result of receiving COVID-19 vaccinations, regardless of the type of vaccine or dose.ResultsEight studies, including 8 cases, participated in the current systematic review. The median age was 61.6 years; 87.5% were female, while 12.5% were male. 75% of the patients received the mRNA COVID-19 vaccines, while 25% received other types. In addition, takotsubo cardiomyopathy occurred in 62.5% of patients after receiving the first dose and another 25% after the second dose of COVID-19 vaccines. Moreover, the mean number of days to the onset of symptoms was 2.62 days. All cases had an elevated troponin test and abnormal ECG findings. The left ventricular ejection fraction (LVEF) was above 50% among all cases. In terms of the average length of stay in the hospital, 62.5% stayed for 10.2 days, and all cases recovered from their symptoms.ConclusionTakotsubo (stress) cardiomyopathy complications that are associated with COVID-19 vaccination are rare, they can be life-threatening. Chest pain should be considered an alarming symptom, especially in those who had received a second dose of the vaccine in the last 3 days. For diagnosis, CK-MB and troponin are better biomarkers to confirm myocarditis than CRP, ESR, and NT-proBNP. All of cases completely recovered.

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“…In addition, CS is considered to be a specific marker of atherosclerotic burden, which might have a common inflammatory background with PVAT. A recent study speculated that there might be a potential correlation between PVAT and CS [ 32 ]. However, the results of this study found that there was no relationship between the FAI and CS, which may be related to the patient population and drug treatment received in this study.…”

Section: Discussionmentioning

confidence: 99%

The Perivascular Fat Attenuation Index Improves the Diagnostic Performance for Functional Coronary Stenosis

Yan

Zhao

Geng

et al. 2022

JCDD

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Background: Coronary computed tomography angiography (CCTA) is an established first-line test in the investigation of patients with suspected coronary artery disease (CAD), while the perivascular fat attenuation index (FAI) derived from CT seems to be a feasible and efficient tool for the identification of ischemia. The association between the FAI and lesion-specific ischemia as assessed by fractional flow reserve (FFR) remains unclear. Methods: In a total of 261 patients, 294 vessels were assessed for CCTA stenosis, vessel-specific FAI, lesion-specific FAI, and plaque characteristics. The diagnostic accuracies of each parameter and the combined approach were analyzed via the receiver operating characteristic curve (ROC) with FFR as the reference standard. The determinants of FAI were statistically analyzed. Results: The cutoff values of vessel-specific FAI and lesion-specific FAI scores calculated according to the Youden index were −70.97 and −73.95 HU, respectively. No significant differences were noted between them; however, they exhibited a strong correlation. No significant differences were noted between the area under the curve (AUC) scores of vessel-specific FAI (0.677), lesion-specific FAI (0.665), and CCTA (0.607) (p > 0.05 for all) results. The addition of two FAI measures to the CCTA showed improvements in the discrimination (AUC) and reclassification ability (relative integrated discrimination improvement (IDI) and category-free net reclassification index (NRI)), vessel-specific FAI (AUC, 0.696; NRI, 49.6%; IDI, 5.9%), and lesion-specific FAI scores (AUC, 0.676; NRI, 43.3%; IDI, 5.4%); (p < 0.01 for all). Multivariate analysis revealed that low-attenuation plaque (LAP) volume was an independent predictor of two FAI measures. Conclusion: The combined approach of adding vessel-specific FAI or lesion-specific FAI scores could improve the identification of ischemia compared with CCTA alone. The LAP volume was the independent risk factor for both tools.

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Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

Cited by 19 publications

References 23 publications

Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis

Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis

Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: a systematic review and meta-analysis

The Perivascular Fat Attenuation Index Improves the Diagnostic Performance for Functional Coronary Stenosis

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