Corneometric, sebumetric and TEWL measurements following the cleaning of atopic skin with a urea emulsion versus a detergent cleanser

Abstract

A non-detergent urea emulsion cleanser and a detergent cleanser with added moisturizers were compared for their effects on stratum corneum moisture, surface lipids and transepidermal water loss (TEWL) of atopic skin. Following a single wash with either cleanser, low corneometry and sebumetry values increased and elevated TEWL values decreased. Over the course of more than 6 h, all induced changes gradually returned to their starting points. In all instances, the changes induced by the urea emulsion lasted significantly longer than those caused by the detergent cleanser. The sebumetry increase after a wash with the lipid-free detergent cleanser indicated that this method recognized not only true lipids but also the lipid-derived and skin lipid-depleting detergents. The transient TEWL normalization with either cleanser could not be attributed to a passing barrier restoration nor to an occlusion. It is speculated that the TEWL changes were related to stratum corneum water binding capacity.

The examination of biophysical skin parameters (transepidermal water loss, skin hydration and pH value) in different body regions in Polish ponies

“…An increase in the parameter indicating epidermal damage was observed in cases of atopic dermatitis in humans (Eberlein-König et al 2000, Rudolph et al 2004, Grupta et al 2008. Similar changes were also observed in dogs, where it was found, among others, that the value of the parameter increases with the severity of the changes assessed with CADESI (Hightower et al 2008, Shimada et al 2009, Cornegliani et al 2011, Marsella 2012.…”

“…condition in human medicine. In case of human patients, they are used, among others, is assessing skin dysfunction in the course of atopic dermatitis as well as in order to determine the efficiency of locally applied treatments, including those used in atopic dermatitis (Dirschka et al 2004, Rudolph and Kownatzki 2004, Aschoff et al 2008, Grupta et al 2008, Hon et al 2011. The measurement of the aforementioned parameters, mainly transepidermal water loss, has recently also attracted the attention of veterinary dermatologists.…”

“…These methods include the examination of transepidermal water loss, corneometry, as well as measuring skin pH and Correspondence to: M. Szczepanik, e-mail: kryll@poczta.onet.pl erythema intensity. The methods were at first used in human medicine (Fluhr et al 2006, Grupta et al 2008 and are now widely applied in various diseases such as topic dermatitis (Eberlein-König et al 2000, Choi et al 2003, Rudolph et al 2004, Grupta et al 2008, contact dermatitis (Laudańska 2003) and in assessing the efficiency of locally applied medicines (Biro et al 2003, Lofler et al 2003, Aschoff et al 2008. Recently, much research involving the assessment of skin biophysical parameters has been published (Dirschka et al 2005, Fluhr et al 2006, Hightower et al 2008, Oh and Oh 2009, Cornegliani et al 2011.…”

“…The method involves the measurement of the electrical capacity of the stratum corneum and reflects the relative hydration of this layer. The method allows for assessing water content in the stratum corneum at the depth of 10-20 μm do 60-100 μm (Rudolph et al 2004, Aschoff et al 2008. Changes in the parameter were observed in cases of damage, metabolic dysfunctions and when local treatment was applied as well as in cases of atopic dermatitis in humans and dogs (Rudolph et al 2004, Aschoff et al 2008, Shimada et al 2009).…”

Biophysical parameters of rats’ skin after the administration of methimazole

“…However, in practice, the open chamber method has been used more frequently in the early diagnosis of atopic dermatitis in dogs (23). Corneometry, in turn, assesses the electric potential of the stratum corneum, which depends on its hydration at the depth of 10 to 100 µm (10,33). A decrease in its value has been observed in humans (33) and dogs (36) with atopic dermatitis in areas with skin changes.…”