Corneal neovascularization: a review of the molecular biology and current therapies

Rolfsen, Michael L; Frisard, Nicholas E; Stern, Ethan M; Foster, Timothy P.; Bhattacharjee, Partha; McFerrin, Harris E.; Clément, Christian; Rodríguez, Paulo C.; Lukiw, Walter J.; Bergsma, Donald R.; Ochoa, Augusto C.; Hill, James M.

doi:10.1586/eop.13.8

Cited by 12 publications

(10 citation statements)

References 178 publications

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“…Moreover, we randomly selected 3 upregulated and 3 downregulated lncRNAs, and then compared their expression patterns with antiangiogenic factors (PDGF and endostatin) and proangiogenic factors (VEGF and iNOS). 1,14,15 We found that these upregulated lncRNAs showed a similar expression pattern as proangiogenic factors, whereas downregulated lncRNAs showed a similar expression pattern as antiangiogenic factors (Fig. 2B), suggesting that these dysregulated lncRNAs may have antiangiogenic or proangiogenic roles in vivo.…”

Section: Differentially Expressed Lncrnas Between Normal Group and Cnmentioning

confidence: 85%

Identification of Corneal Neovascularization–Related Long Noncoding RNAs Through Microarray Analysis

Huang

Liu

et al. 2015

Cornea

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Section: Differentially Expressed Lncrnas Between Normal Group and Cnmentioning

confidence: 85%

Identification of Corneal Neovascularization–Related Long Noncoding RNAs Through Microarray Analysis

Huang

Liu

et al. 2015

Cornea

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“…[ 29 ] It has also been proposedthat CNV can begin with hypoxia-induced upregulation of proangiogenic cytokines (such as VEGF) and downregulation of antiangiogenic cytokines (such as pigment epithelium derived factor (PEDF)). [ 30 ]…”

Section: Discussionmentioning

confidence: 99%

Investigating the association between angiogenic cytokines and corneal neovascularization in sulfur mustard intoxicated subjects 26 years after exposure

Abbaszadeh¹,

Aidenloo²,

Nematollahi³

et al. 2014

Toxicol Int

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Objectives:This study aimed to evaluate the associations between the concentrations of three major angiogenic cytokines–vascular endothelial growth factor-A165 (VEGF-A165), basic fibroblast growth factor (bFGF), and platelet-derived growth factor-BB (PDGF-BB)–in the tear of sulfur mustard (SM)-exposed subjects and corneal neovascularization (CNV) 26 years after exposure.Materials and Methods:The concentrations of VEGF-A, bFGF, and PDGF-BB were measured by enzyme-linked immunosorbent assay (ELISA) in reflex tears of (i) SM-injured patients with CNV (positive case group including 18 individuals) and (ii) SM-injured patients without CNV (negative case group including 22 individuals). Then results were compared to corresponding values obtained from tears of 40 healthy control subjects.Results:The mean concentrations of all investigated growth factors, VEGF-A165, bFGF, and PDGF-BB, were significantly higher in positive cases than controls (P ≤ 0.001, P = 0.028, and P = 0.041, respectively). Whereas, VEGF-A165 was the only growth factor which displayed significantly elevated concentrations in negative case group compared to the healthy individuals (P = 0.030). Additionally, the mean level of VEGF-A165 was also higher in positive patient group than negative patients (P = 0.022). Subjects with increased concentrations of tear VEGF-A165 were more than 10 times more likely to suffer from CNV than normal individuals (odds ratio (OR) = 10.43, confidence interval (CI): 2.14–38.46, P = 0.001), while elevated levels of bFGF and PDGF-BB increased the risk of CNV by about twofold.Conclusion:Although all investigated cytokines had increased in tears of positive patients, VEGF-A was the only one which showed a significant correlation with the severity of CNV, and thus played a crucial role in corneal angiogenesis.

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“…1,2 This condition is reportedly associated with corneal vascularization, which is a much more prevalent finding in both human beings and animals. [3][4][5][6] The difference in prevalence between the conditions could be explained by special pathophysiologic circumstances. Corneal vascularization and stromal intracorneal hemorrhage (ICH) are both complications that may threaten visual status.…”

Section: Introductionmentioning

confidence: 99%

Intracorneal stromal hemorrhage in dogs and its associations with ocular and systemic disease: 39 cases

Violette

Ledbetter

2016

Veterinary Ophthalmology

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Corneal neovascularization: a review of the molecular biology and current therapies

Cited by 12 publications

References 178 publications

Identification of Corneal Neovascularization–Related Long Noncoding RNAs Through Microarray Analysis

Identification of Corneal Neovascularization–Related Long Noncoding RNAs Through Microarray Analysis

Investigating the association between angiogenic cytokines and corneal neovascularization in sulfur mustard intoxicated subjects 26 years after exposure

Intracorneal stromal hemorrhage in dogs and its associations with ocular and systemic disease: 39 cases

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