Corneal keloid

Bourcier, Tristan; Baudrimont, M.; Boutboul, Sandrine; Thomas, F; Borderie, Vincent; Laroche, L.

doi:10.1016/j.jcrs.2003.08.025

Cited by 23 publications

(4 citation statements)

References 14 publications

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“…As opposed to hypertrophic scars, which are restricted to the initial site of injury, keloids may overgrow the initial lesion covering large parts of the corneal surface and are often observed to be recurrent. Keloids clinically appear as defined, white, elevated tissue and are characterized by a hyperplastic epithelium, disruption of the Bowman layer and contain disorganized stromal collagen fibers, as well as activated fibroblasts and may be paralleled by neovascularization [125,126,127,128]. Interestingly, also spontaneous keloid formations without previous corneal injury have been reported [129,130,131].…”

Section: The Fibrotic Response In Corneal Repairmentioning

confidence: 99%

Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities

Bukowiecki

Hos

Cursiefen

et al. 2017

IJMS

136

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The cornea and the skin are both organs that provide the outer barrier of the body. Both tissues have developed intrinsic mechanisms that protect the organism from a wide range of external threats, but at the same time also enable rapid restoration of tissue integrity and organ-specific function. The easy accessibility makes the skin an attractive model system to study tissue damage and repair. Findings from skin research have contributed to unravelling novel fundamental principles in regenerative biology and the repair of other epithelial-mesenchymal tissues, such as the cornea. Following barrier disruption, the influx of inflammatory cells, myofibroblast differentiation, extracellular matrix synthesis and scar formation present parallel repair mechanisms in cornea and skin wound healing. Yet, capillary sprouting, while pivotal in proper skin wound healing, is a process that is rather associated with pathological repair of the cornea. Understanding the parallels and differences of the cellular and molecular networks that coordinate the wound healing response in skin and cornea are likely of mutual importance for both organs with regard to the development of regenerative therapies and understanding of the disease pathologies that affect epithelial-mesenchymal interactions. Here, we review the principal events in corneal wound healing and the mechanisms to restore corneal transparency and barrier function. We also refer to skin repair mechanisms and their potential implications for regenerative processes in the cornea.

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Section: The Fibrotic Response In Corneal Repairmentioning

confidence: 99%

Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities

Bukowiecki

Hos

Cursiefen

et al. 2017

IJMS

136

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“…Recurrence has been reported after SK, LK, PK, and PTK [2, 6]. To prevent the recurrence, AMT has been combined with SK in several reports [7, 8] because AM has anti-inflammatory and anti-fibroblastic properties. These previous reports suggested AMT was successful in preventing recurrence [7, 8].…”

Section: Discussionmentioning

confidence: 99%

“…To prevent the recurrence, AMT has been combined with SK in several reports [7, 8] because AM has anti-inflammatory and anti-fibroblastic properties. These previous reports suggested AMT was successful in preventing recurrence [7, 8]. However, corneal keloids recurred in all three of our patients treated with SK and AMT.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, we used an intraoperative application of MMC in two patients along with SK and AMT to suppress activated fibroblasts and keratocytes in the residual stroma, but the lesions recurred nonetheless. There are several speculations on the role of vascularization, innervation, or myofibroblastic transformation in the formation and recurrence of a corneal keloid based on histological and ultrastructural studies [8–10]. While diffuse and anterior vascularization of corneal keloids was described in some reports, other reports demonstrated the presence of few vessels in the lesion.…”

Section: Discussionmentioning

confidence: 99%

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Corneal keloid: four case reports of clinicopathological features and surgical outcome

et al. 2016

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BackgroundSurgical outcome of corneal keloid is largely variable depending on reports, although surgical management is inevitable in visually significant cases. We here report clinical features, histopathological findings, and surgical outcome of four cases of corneal keloid.Case presentationFour Korean male patients without a history of corneal trauma or disease were clinically and histologically evaluated for a slowly-growing, white opacity in the cornea. On slit lamp examination, corneal lesions appeared as a solitary, pearly white, well-circumscribed nodule with a smooth and glistening surface. Because the lesions involved the visual axis deteriorating the visual acuity, the nodules were surgically removed by superficial keratectomy in all patients. Amniotic membrane transplantation was combined in three patients, and an intraoperative mitomycin C application in two patients. Hematoxylin-eosin staining of the excised nodules revealed epithelial hyperplasia, Bowman’s layer disruption, thick and irregularly-arranged collagen fibers in the stroma, and accumulation of prominent fibroblasts, which are consistent with the diagnosis of corneal keloid. The corneal keloids recurred in all patients within 10 months of surgical excision and outgrew the boundary of the excised area.ConclusionA diagnosis of corneal keloid should be suspected in patients presenting with an enlarging, white, glistening corneal nodule, even in the absence of a history of corneal trauma or disease. The recurrence is common after surgical excision, and the lesion can be exacerbated by surgery.

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